https://inter.knmu.edu.ua/ <p>Founder, editorial board and publisher: <a href="https://ror.org/01sks0025"><strong>Kharkiv National Medical University</strong></a></p> <p>Online ISSN: 2409-9988.</p> <p>DOI: 10.35339/ic</p> <p>The journal is assigned to the scientific professional publications of Ukraine in the field of medical sciences by the Ministry of Education and Science of Ukraine (September 24, 2020) <strong>"Б" category</strong> for specialties <strong>221</strong> - dentistry, <strong>222</strong> - medicine, <strong>223</strong> - nursing, <strong>225</strong> - medical psychology, <strong>227</strong> - therapy and rehabilitation, <strong>228</strong> - pediatrics.</p> <p><strong>Editorial and publisher address:</strong>&nbsp;<br>61022, Kharkov, Nauky Ave., 4<br>Tel.: +38 063 069 9000 <span class="VIiyi" lang="en"><span class="JLqJ4b ChMk0b" data-language-for-alternatives="en" data-language-to-translate-into="uk" data-phrase-index="0" data-number-of-phrases="1">(Monday to Friday 9: 00-17: 00 Ukrainian time, except holidays)</span></span>&nbsp;<br>E-mail: msz.journal@knmu.edu.ua</p> Kharkiv National Medical Unviersity en-US Inter Collegas 2409-9988 <p><span class="HwtZe" lang="en"><span class="jCAhz ChMk0b"><span class="ryNqvb">"Inter Collegas" is an open access journal: all articles are published in open access without an embargo period, under the terms of the CC BY-NC-SA (Creative Commons Attribution ‒ Noncommercial ‒ Share Alike) license;</span></span> <span class="jCAhz ChMk0b"><span class="ryNqvb">the content is available to all readers without registration from the moment of its publication.</span></span> <span class="jCAhz ChMk0b"><span class="ryNqvb">Electronic copies of the archive of journals are placed in the repositories of the KhNMU and </span></span>V.I. Vernadsky National Library of Ukraine.<br></span></p> <p><span class="HwtZe" lang="en">Copyright Agreement<br>1. This Agreement on the transfer of rights to use the work from the Co-authors to the publisher (hereinafter the Agreement) is concluded between all the Co-authors of the work, represented by the Corresponding Author, and Kharkiv National Medical University (hereinafter the University), represented by an authorized representative of the Editorial Board of scientific journals (hereinafter the Editorial Board).<br>2. This Agreement is an accession agreement within the meaning of clause 1 of Article 634 of the Civil Code of Ukraine: that is, a contract, "the terms of which are established by one of the parties in forms or other standard forms, which can be concluded only by joining the other party to the proposed contract as a whole. The other party cannot offer its terms of the contract." The party that established the terms of this contract is the University.<br>3. If there is more than one author, the authors choose the Corresponding Author, who communicates with the Editorial Board on his own behalf and on behalf of all Co-authors regarding the publication of a written work of a scientific nature (article or review, hereinafter referred to as the Work).<br>4. The contract begins from the moment of submission of the manuscript of the Work by the Corresponding Author to the Editorial Board, which confirms the following:<br>4.1. all Co-authors of the Work are familiar with and agree with its content, at all stages of reviewing and editing the manuscript and the existence of the published Work;<br>4.2. all Co-authors of the Work are familiar with and agree to the terms of this Agreement.<br>5. The published Work is in electronic form in public access on the websites of the University and any websites and electronic databases in which the Work is posted by the University and is available to readers under the terms of the "Creative Commons" license (Attribution NonCommercial Sharealike 4.0 International)" or more free licenses "Creative Commons 4.0".<br>6. The Corresponding Author transfers, and the University receives, the non-exclusive property right to use the Work by placing the latter on the University's websites for the entire term of copyright. The University participates in the creation of the final version of the Work by reviewing and editing the manuscript of the article or review provided to the Editorial Board by the Corresponding Author, translating the Work into any languages. 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At the time of submission of the manuscript to the Editorial Board and all stages of its editing and review, the manuscript must not have already been published or submitted to other editorial offices.<br>12. The right transferred under this Agreement extends to the territory of Ukraine and foreign countries.<br>13. The rights of Co-authors include the requirement to indicate their names on all copies of the Work or during any public use or public mention of the Work; the requirement to preserve the integrity of the Work; legal opposition to any distortion or other encroachment on the Work, which may harm the honor and reputation of the Co-authors.<br>14. Co-authors have the right to control their personal non-property rights by familiarizing themselves with the text (content) and form of the Work before its publication on the University's website, when transferring it to a printing company for reproduction or when using the Work in other ways.<br>15. The Co-authors, in addition to the property rights not transferred under this Agreement and taking into account the non-exclusive nature of the rights transferred under this Agreement, retain the property rights to finalize the Work and to use certain parts of the Work in other works created by the Co-authors.<br>16. The Co-authors are obliged to notify the Editorial Board of all errors in the Work, discovered by them independently after the publication of the Work, and to take all measures to eliminate such errors as soon as possible.<br>17. The University undertakes to indicate the names of the Co-authors on all copies of the Work during any public use of the Work. The list of Co-authors may be shortened according to the rules for the formation of bibliographic descriptions determined by the University or third parties.<br>18. The University undertakes not to violate the integrity of the Work, to agree with the Corresponding Author on all changes made to the Work during processing and editing.<br>19. In case of violation of their obligations under this Agreement, its parties bear the responsibility defined by this Agreement and the current legislation of Ukraine. All disputes under the Agreement are resolved through negotiations, and if the negotiations do not resolve the dispute – in the courts of the city of Kharkiv.<br>20. The parties are not responsible for the violation of their obligations under this Agreement, if it occurred through no fault of theirs. The party is considered innocent if it proves that it has taken all measures dependent on it for the proper fulfillment of the obligation.<br>21. The Co-authors are responsible for the truthfulness of the facts, quotes, references to legislative and regulatory acts, other official documentation, the scientific validity of the Work, all types of responsibility to third parties who have claimed their rights to the Work. The co-authors reimburse the University for all costs caused by claims of third parties for infringement of copyright and other rights to the Work, as well as additional material costs related to the elimination of identified defects. </span></p> https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.1.sts <p><strong>Introduction.</strong> Inflammation is a reaction of living tissue on injury. Nowadays there is a wide spectrum of anti-inflammatory medications that are used for the treatment of many problems. But because their application is associated with a wide range of side effects, there is a need for the development of new pharmaceutical compositions to maximise patient safety.</p> <p><strong>Aim.</strong> To carry out biochemical evaluation of anti-inflammatory action of celecoxib in combination with caffeine on the biochemical markers of inflammation (sialic acids and ceruloplasmin) and to determine its anti-exudative action on formalin-induced paw edema in rats.</p> <p><strong>Materials and Methods.</strong> The study involved male Wistar Albino Glaxo (WAG) line rats, divided into six treatment groups: control, formalin-induced, celecoxib (5 mg/kg), caffeine (0.6 mg/kg), a combination of celecoxib and caffeine (5 mg and 0.6 mg/kg), and diclofenac sodium (8 mg/kg). Biochemical studies were carried out by using the blood serum samples of white laboratory rats (WAG line). Anti-inflammatory activity of celecoxib and its pharmaceutical composition with caffeine was studied using the formalin-induced paw edema model. The animals were divided into the same groups as in the Anti-Exudative Activity (AEA) study.</p> <p><strong>Results. </strong>It was shown, that composition of celecoxib and caffeine exerted higher anti-inflammatory activity versus celecoxib and it is efficient in relation to the exudation processes. Biochemical studies of celecoxib, caffeine and their composition on the level of sialic acid level and ceruloplasmin level in the blood serum as well as study of anti-exudative activity of the proposed composition have shown, that caffeine potentiates pharmacological activity of celecoxib in formalin-induced paw edema model.</p> <p><strong>Conclusion.</strong> The findings indicate that the combination of celecoxib and caffeine is a promising therapeutic option for inflammatory conditions.</p> <p><strong><em>Keywords:</em> </strong><em>аnti-inflammatory drugs, anti-exudative action, biomarkers of inflammation.</em></p> <p>Archived: <a href="https://doi.org/10.5281/zenodo.15281956" target="_blank" rel="noopener">https://doi.org/10.5281/zenodo.15281956</a></p> G.О. Syrova T.S. Tishakova O.V. Savelieva N.M. Chalenko Copyright (c) 2025 Syrova G.О., Tishakova T.S., Savelieva O.V., Chalenko N.M. https://creativecommons.org/licenses/by-nc-sa/4.0/ 2025-03-31 2025-03-31 12 1 5 11 10.35339/ic.2025.12.1.sts https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.1.gvb <p><strong>In press</strong></p> <p><strong>Background. </strong>OsteoArthritis of the Knee Joint (OAKJ) is a progressive incurable disease, which in severe cases necessitates total joint arthroplasty.</p> <p><strong>Aim.</strong> To conduct a systematic analysis of the scientific literature on the prospects and possibilities of early diagnosis of monogonarthrosis.</p> <p><strong>Materials and Methods. </strong>A literature search was conducted in the PubMed and Medline databases for the period 2010–2024, using the following keywords: "osteoarthrosis of the knee joint", "monogonarthrosis" (42 sources).</p> <p><strong>Results. </strong>The mainstream of modern literature on the problem of clinical diagnosis of osteoarthritis, including with monoarticular lesions, includes the results of studies of biomarkers of hyaluronic cartilage degradation both in the case of visualization on magnetic resonance imaging scans and according to the data of biochemical and immunological analyses of blood serum. The importance of radiological signs of mainly early stages of osteoarthritis of the knee joint is also separately studied. There are isolated contradictory professional works on the correlation of clinical and radiological manifestations of gonarthrosis. Reports on the results of a comprehensive clinical and radiological examination of patients with monogonarthrosis are almost not presented in the literature.</p> <p><strong>Conclusions</strong><strong>.</strong> It was established on the basis of information and analytical studies of modern scientific literature that osteoarthritis of the knee joint is accompanied by persistent pain, significant limitation of lower limb function, decreased working capacity, which often leads to joint replacement. Diagnosis of osteoarthritis in the early stages is difficult due to the lack of pathognomonic clinical, radiological and laboratory indicators, and in the case of monogonarthrosis with synovitis it is complicated by differentiation with specific arthritises of the knee joint. The above data indicate the feasibility of further research to find opportunities for improving methods for early diagnosis of monogonarthrosis.</p> <p><em><strong>Keywords:</strong> osteoarthritis of the knee joint, pathogenesis, clinical and laboratory studies.</em></p> <p>Archived: <a href="https://doi.org/10.5281/zenodo.15281244">https://doi.org/10.5281/zenodo.15281244</a>&nbsp;</p> G.G. Golka V.V. Vesnin V.V. Burlaka A.O. Oliynyk O.G. Fadieiev O.V. Goptsy E.Yu. Frolova-Romaniuk Copyright (c) 2025 Golka G.G., Vesnin V.V., Burlaka V.V., Oliynyk A.O., Fadieiev O.G., Goptsy O.V., Frolova-Romanyuk E.Yu. https://creativecommons.org/licenses/by-nc-sa/4.0/ 2025-03-31 2025-03-31 12 1 10.35339/ic.2025.12.1.gvb https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.1.ssp <p><strong>In press</strong></p> <p><strong>Background. </strong>With a view of primary prevention of diseases common in the world, medical workers and educators can effectively work together within teaching valeological disciplines at higher education institutions. Medical information should be adapted for non-medical students using the methods of scaling, aggregation, balancing and system analysis. Their application requires studying the content of main topics of valeological disciplines, determining the boundaries of didactic adaptation and testing in different higher education establishments. Adaptation of medical information on risk factors for understanding by non-medical students has not been stu­died enough.</p> <p><strong>Aim.</strong> To study the characteristics and interrelationships of risk factors of socially significant diseases for the didactic adaptation of the content of valeological disciplines.</p> <p><strong>Materials and Methods.</strong> The bibliosemantic method, comparative method, and system ana­lysis method were used for the study. The analysis takes into account the experience of primary prevention of diseases and teaching valeological disciplines in higher education institutions in Ukraine and Germany.</p> <p><strong>Results and Conclusions.</strong> The system of risk factors for diseases that are responsible for a&nbsp;significant number of deaths in most countries of the world is the subject of study of modern valeological disciplines. Medical research allows us to divide risk factors into controllable, conditio­nally controllable and uncontrollable. The impact of the first two groups of risk factors on health can be eliminated or significantly weakened by forming non-medical students’ valeological competence and adherence to a healthy lifestyle throughout life. The programs for primary prevention of socially significant diseases should include recommendations for quitting smoking, alcohol abuse, drug use, overeating, overfatigue, hypodynamia, or, conversely, extreme sports, and unprotected sex. Didactic adaptation of complex medical information is needed for valeological education of non-medical students. Its algorithms are analyzed in this article.</p> <p><strong><em>Keywords:</em></strong><em> primary prophylaxis, <span class="HwtZe" lang="en"><span class="jCAhz ChMk0b"><span class="ryNqvb">preventable disease</span></span></span>, controllable risk factors, healthy lifestyle, valeological competence, didactic adaptation.</em></p> <p>Archived: <a href="https://doi.org/10.5281/zenodo.15178107" target="_blank" rel="noopener">https://doi.org/10.5281/zenodo.15178107</a></p> A.S. Shevchenko V.V. Shevchenko K.G. Pomogaybo S.I. Danylchenko G.W. Brown O.L. Shumskyi Ye.Ye. Bilyi R.А. Zhoga V.I. Yushko Copyright (c) 2025 Shevchenko A.S., Shevchenko V.V., Pomogaybo K.G., Danylchenko S.I., Brown G.W., Shumskyi O.L., Bilyi Ye.Ye., Zhoga R.А., Yushko V.I. https://creativecommons.org/licenses/by-nc-sa/4.0/ 2025-03-31 2025-03-31 12 1 10.35339/ic.2025.12.1.ssp https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.1.sss <p><strong>In press</strong></p> <p><strong>Background.</strong> Throughout the time of martial law in Ukraine, the number of military service members with mild degrees of intellectual impairment has increased, which requires significant attention to nursing support during the period of diagnostic, medical, therapeutic, and rehabilitation medical practice. The importance of nursing support for military personnel with mild intellectual disorders during exacerbation of gastrointestinal diseases in the process of medical rehabilitation should be better investigated, which is due to the increase in the number of military personnel with this nosology and the need to select methodological recommendations for improving nursing support for patients in the process of medical rehabilitation. The relevance of this study will be maintained during warfare and in the first years after the war. It will also help medical professionals better understand the specifics of supporting patients with intellectual and cognitive developmental disorders.</p> <p><strong>Aim. </strong>Analysis the degree of quality of nursing support for military personnel with mild intellectual impairment with gastrointestinal diseases during medical rehabilitation.</p> <p><strong>Materials and Methods.</strong> Bibliosemantic methods and system analysis were used. PubMed, Google Scholar sources, orders of the Ministry of Health of Ukraine were analyzed. The article is written in the form of a short scientific report.</p> <p><strong>Results &amp; Conclusions. </strong>Nursing support for military personnel with intellectual disabilities cannot be implemented qualitatively and effectively without prior training of specialists. Nurses often cannot choose the right approach to these patients due to a lack of relevant experience and understanding of the needs of people with intellectual disоrders. Our conclusion proposed possible solutions to this problem through various and specific ways to improve the skills of medical professionals.</p> <p><em><strong>Keywords:</strong></em> <em>military medicine, cognitive developmental disorders, warfare regions, advanced training, behavioral disorders</em><em>.</em></p> V.O. Sushchenko V.I. Smirnova E.M. Sushchenko Copyright (c) 2025 Sushchenko V.O., Smirnova V.I., Sushchenko E.M. https://creativecommons.org/licenses/by-nc-sa/4.0/ 2025-03-31 2025-03-31 12 1 10.35339/ic.2025.12.1.sss https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.1.kpk <p><strong>In press</strong></p> <p><strong>Background</strong>. English-Medium Instruction (EMI) is a popular trend in modern higher education. Statistical data indicate a constant increase in the number of English-Taught Programmes (ETP) and courses, and Europe is the world leader in EMI implementation. Programmes in Medicine and Health Sciences are not included in the group of main ETPs in the world, European indicators of their number are lower than global, but they also demonstrate an increase in the number. Since these programmes were not described in detail, the <strong>aim</strong> of our work was to study the availability, distribution, and features of ETPs in Medicine and Health Sciences in Europe.</p> <p><strong>Materials and Methods.</strong> Information from the websites of medical schools of the European Union/European Economic Area was studied using systematic analysis, comparative and bibliosemantic methods. The analysis covered 577 ETPs (160 higher education institutions from 26 countries where English has the status of a foreign language).</p> <p><strong>Results.</strong> EMI in Medicine and Health Sciences has been implemented in two forms: single medium and partial (bilingual). The leader in the total number of completely ETPs is the Netherlands. The most common are Master programmes. Single-cycle programmes in medicine, dentistry and pharmacology are available in the Baltic countries, Central East Europe, South East Europe, South West Europe. Bachelor programmes in English are the smallest in number and are offered in selected countries. Bilingual programmes were found in Spain, Austria, Luxembourg, and Sweden.</p> <p><strong>Conclusions.</strong> Teaching Medicine and Health Sciences in the medium of English is a common practice in the EU/EEA, but the choice of the type of teaching (single medium or bilingual) and the education level depend on the language policy of the country, the target group of students, and the internationalization strategy of a particular higher education institution.</p> <p><em><strong>Keywords: </strong>English language, medium of instruction, English taught programme, higher education, medical higher education institution, Europe.</em></p> <p>Archived: <a href="https://doi.org/10.5281/zenodo.15245658" target="_blank" rel="noopener">https://doi.org/10.5281/zenodo.15245658</a></p> I. Korneyko O. Petrova O. Krainenko H. Ovsiannikova Copyright (c) 2025 Korneyko I., Petrova O., Krainenko O., Ovsiannikova H. https://creativecommons.org/licenses/by-nc-sa/4.0/ 2025-03-31 2025-03-31 12 1 10.35339/ic.2025.12.1.kpk