Inter Collegas

Biochemical evaluation of anti-inflammatory action of celecoxib and caffeine in a formalin pain model in rats

G.О. Syrova, T.S. Tishakova, O.V. Savelieva, N.M. Chalenko — Mon, 31 Mar 2025 00:00:00 +0300

Introduction. Inflammation is a reaction of living tissue on injury. Nowadays there is a wide spectrum of anti-inflammatory medications that are used for the treatment of many problems. But because their application is associated with a wide range of side effects, there is a need for the development of new pharmaceutical compositions to maximise patient safety.

Aim. To carry out biochemical evaluation of anti-inflammatory action of celecoxib in combination with caffeine on the biochemical markers of inflammation (sialic acids and ceruloplasmin) and to determine its anti-exudative action on formalin-induced paw edema in rats.

Materials and Methods. The study involved male Wistar Albino Glaxo (WAG) line rats, divided into six treatment groups: control, formalin-induced, celecoxib (5 mg/kg), caffeine (0.6 mg/kg), a combination of celecoxib and caffeine (5 mg and 0.6 mg/kg), and diclofenac sodium (8 mg/kg). Biochemical studies were carried out by using the blood serum samples of white laboratory rats (WAG line). Anti-inflammatory activity of celecoxib and its pharmaceutical composition with caffeine was studied using the formalin-induced paw edema model. The animals were divided into the same groups as in the Anti-Exudative Activity (AEA) study.

Results. It was shown, that composition of celecoxib and caffeine exerted higher anti-inflammatory activity versus celecoxib and it is efficient in relation to the exudation processes. Biochemical studies of celecoxib, caffeine and their composition on the level of sialic acid level and ceruloplasmin level in the blood serum as well as study of anti-exudative activity of the proposed composition have shown, that caffeine potentiates pharmacological activity of celecoxib in formalin-induced paw edema model.

Conclusion. The findings indicate that the combination of celecoxib and caffeine is a promising therapeutic option for inflammatory conditions.

Keywords: аnti-inflammatory drugs, anti-exudative action, biomarkers of inflammation.

Archived: https://doi.org/10.5281/zenodo.15281956

Early diagnosis of monogonarthrosis (literature review)

Mon, 31 Mar 2025 00:00:00 +0300

In press

Background. OsteoArthritis of the Knee Joint (OAKJ) is a progressive incurable disease, which in severe cases necessitates total joint arthroplasty.

Aim. To conduct a systematic analysis of the scientific literature on the prospects and possibilities of early diagnosis of monogonarthrosis.

Materials and Methods. A literature search was conducted in the PubMed and Medline databases for the period 2010–2024, using the following keywords: "osteoarthrosis of the knee joint", "monogonarthrosis" (42 sources).

Results. The mainstream of modern literature on the problem of clinical diagnosis of osteoarthritis, including with monoarticular lesions, includes the results of studies of biomarkers of hyaluronic cartilage degradation both in the case of visualization on magnetic resonance imaging scans and according to the data of biochemical and immunological analyses of blood serum. The importance of radiological signs of mainly early stages of osteoarthritis of the knee joint is also separately studied. There are isolated contradictory professional works on the correlation of clinical and radiological manifestations of gonarthrosis. Reports on the results of a comprehensive clinical and radiological examination of patients with monogonarthrosis are almost not presented in the literature.

Conclusions. It was established on the basis of information and analytical studies of modern scientific literature that osteoarthritis of the knee joint is accompanied by persistent pain, significant limitation of lower limb function, decreased working capacity, which often leads to joint replacement. Diagnosis of osteoarthritis in the early stages is difficult due to the lack of pathognomonic clinical, radiological and laboratory indicators, and in the case of monogonarthrosis with synovitis it is complicated by differentiation with specific arthritises of the knee joint. The above data indicate the feasibility of further research to find opportunities for improving methods for early diagnosis of monogonarthrosis.

Keywords: osteoarthritis of the knee joint, pathogenesis, clinical and laboratory studies.

Archived: https://doi.org/10.5281/zenodo.15281244

The system of risk factors for diseases in valeological disciplines

Mon, 31 Mar 2025 00:00:00 +0300

In press

Background. With a view of primary prevention of diseases common in the world, medical workers and educators can effectively work together within teaching valeological disciplines at higher education institutions. Medical information should be adapted for non-medical students using the methods of scaling, aggregation, balancing and system analysis. Their application requires studying the content of main topics of valeological disciplines, determining the boundaries of didactic adaptation and testing in different higher education establishments. Adaptation of medical information on risk factors for understanding by non-medical students has not been studied enough.

Aim. To study the characteristics and interrelationships of risk factors of socially significant diseases for the didactic adaptation of the content of valeological disciplines.

Materials and Methods. The bibliosemantic method, comparative method, and system analysis method were used for the study. The analysis takes into account the experience of primary prevention of diseases and teaching valeological disciplines in higher education institutions in Ukraine and Germany.

Results and Conclusions. The system of risk factors for diseases that are responsible for a significant number of deaths in most countries of the world is the subject of study of modern valeological disciplines. Medical research allows us to divide risk factors into controllable, conditionally controllable and uncontrollable. The impact of the first two groups of risk factors on health can be eliminated or significantly weakened by forming non-medical students’ valeological competence and adherence to a healthy lifestyle throughout life. The programs for primary prevention of socially significant diseases should include recommendations for quitting smoking, alcohol abuse, drug use, overeating, overfatigue, hypodynamia, or, conversely, extreme sports, and unprotected sex. Didactic adaptation of complex medical information is needed for valeological education of non-medical students. Its algorithms are analyzed in this article.

Keywords: primary prophylaxis, preventable disease, controllable risk factors, healthy lifestyle, valeological competence, didactic adaptation.

Archived: https://doi.org/10.5281/zenodo.15178107

English-medium instruction in European medical schools: availability and distribution

I. Korneyko, O. Petrova, O. Krainenko, H. Ovsiannikova — Mon, 31 Mar 2025 00:00:00 +0300

In press

Background. English-Medium Instruction (EMI) is a popular trend in modern higher education. Statistical data indicate a constant increase in the number of English-Taught Programmes (ETP) and courses, and Europe is the world leader in EMI implementation. Programmes in Medicine and Health Sciences are not included in the group of main ETPs in the world, European indicators of their number are lower than global, but they also demonstrate an increase in the number. Since these programmes were not described in detail, the aim of our work was to study the availability, distribution, and features of ETPs in Medicine and Health Sciences in Europe.

Materials and Methods. Information from the websites of medical schools of the European Union/European Economic Area was studied using systematic analysis, comparative and bibliosemantic methods. The analysis covered 577 ETPs (160 higher education institutions from 26 countries where English has the status of a foreign language).

Results. EMI in Medicine and Health Sciences has been implemented in two forms: single medium and partial (bilingual). The leader in the total number of completely ETPs is the Netherlands. The most common are Master programmes. Single-cycle programmes in medicine, dentistry and pharmacology are available in the Baltic countries, Central East Europe, South East Europe, South West Europe. Bachelor programmes in English are the smallest in number and are offered in selected countries. Bilingual programmes were found in Spain, Austria, Luxembourg, and Sweden.

Conclusions. Teaching Medicine and Health Sciences in the medium of English is a common practice in the EU/EEA, but the choice of the type of teaching (single medium or bilingual) and the education level depend on the language policy of the country, the target group of students, and the internationalization strategy of a particular higher education institution.

Keywords: English language, medium of instruction, English taught programme, higher education, medical higher education institution, Europe.

Archived: https://doi.org/10.5281/zenodo.15245658