Inter Collegas https://inter.knmu.edu.ua/ <p>Founder, editorial board and publisher: <a href="https://ror.org/01sks0025"><strong>Kharkiv National Medical University</strong></a></p> <p>Online ISSN: 2409-9988.</p> <p>DOI: 10.35339/ic</p> <p>The journal is assigned to the scientific professional publications of Ukraine in the field of medical sciences by the Ministry of Education and Science of Ukraine (September 24, 2020) <strong>"Б" category</strong> for specialties <strong>221</strong> - dentistry, <strong>222</strong> - medicine, <strong>223</strong> - nursing, <strong>225</strong> - medical psychology, <strong>227</strong> - therapy and rehabilitation, <strong>228</strong> - pediatrics.</p> <p><strong>Editorial and publisher address:</strong>&nbsp;<br>61022, Kharkov, Nauky Ave., 4<br>Tel.: +38 063 069 9000 <span class="VIiyi" lang="en"><span class="JLqJ4b ChMk0b" data-language-for-alternatives="en" data-language-to-translate-into="uk" data-phrase-index="0" data-number-of-phrases="1">(Monday to Friday 9:00-17:00 Ukrainian time, except holidays)</span></span>&nbsp;<br>E-mail: ic.journal@knmu.edu.ua</p> en-US <p><span class="HwtZe" lang="en"><span class="jCAhz ChMk0b"><span class="ryNqvb">"Inter Collegas" is an open access journal: all articles are published in open access without an embargo period, under the terms of the CC BY-NC-SA (Creative Commons Attribution ‒ Noncommercial ‒ Share Alike) license;</span></span> <span class="jCAhz ChMk0b"><span class="ryNqvb">the content is available to all readers without registration from the moment of its publication.</span></span> <span class="jCAhz ChMk0b"><span class="ryNqvb">Electronic copies of the archive of journals are placed in the repositories of the KhNMU and </span></span>V.I. Vernadsky National Library of Ukraine.<br></span></p> <p><span class="HwtZe" lang="en">Copyright Agreement<br>1. This Agreement on the transfer of rights to use the work from the Co-authors to the publisher (hereinafter the Agreement) is concluded between all the Co-authors of the work, represented by the Corresponding Author, and Kharkiv National Medical University (hereinafter the University), represented by an authorized representative of the Editorial Board of scientific journals (hereinafter the Editorial Board).<br>2. This Agreement is an accession agreement within the meaning of clause 1 of Article 634 of the Civil Code of Ukraine: that is, a contract, "the terms of which are established by one of the parties in forms or other standard forms, which can be concluded only by joining the other party to the proposed contract as a whole. The other party cannot offer its terms of the contract." The party that established the terms of this contract is the University.<br>3. If there is more than one author, the authors choose the Corresponding Author, who communicates with the Editorial Board on his own behalf and on behalf of all Co-authors regarding the publication of a written work of a scientific nature (article or review, hereinafter referred to as the Work).<br>4. The contract begins from the moment of submission of the manuscript of the Work by the Corresponding Author to the Editorial Board, which confirms the following:<br>4.1. all Co-authors of the Work are familiar with and agree with its content, at all stages of reviewing and editing the manuscript and the existence of the published Work;<br>4.2. all Co-authors of the Work are familiar with and agree to the terms of this Agreement.<br>5. The published Work is in electronic form in public access on the websites of the University and any websites and electronic databases in which the Work is posted by the University and is available to readers under the terms of the "Creative Commons" license (Attribution NonCommercial Sharealike 4.0 International)" or more free licenses "Creative Commons 4.0".<br>6. The Corresponding Author transfers, and the University receives, the non-exclusive property right to use the Work by placing the latter on the University's websites for the entire term of copyright. The University participates in the creation of the final version of the Work by reviewing and editing the manuscript of the article or review provided to the Editorial Board by the Corresponding Author, translating the Work into any languages. For the participation of the University in the finalization of the Work, the Co-authors agree to pay the invoice issued to them by the University, if such payment is provided by the University. The size and procedure of such payment are not the subject of this contract.<br>7. The University has the right to reproduce the Work or its parts in electronic and printed forms, to make copies, permanent archival storage of the Work, distribution of the Work on the Internet, repositories, scientometric databases, commercial networks, including for monetary compensation from third parties.<br>8. The co-authors guarantee that the manuscript of the Work does not use works whose copyright belongs to third parties.<br>9. The authors of the Work guarantee that at the time of submission of the manuscript of the Work to the Editorial Board, the property rights to the Work belong only to them, neither in whole nor in part have they been transferred to anyone (not alienated), they are not the subject of a lien, litigation or claims by third parties.<br>10. The Work may not be posted on the University's website if it violates a person's right to the privacy of his personal and family life, harms public order and health.<br>11. The work may be withdrawn by the Editorial Board from the University websites, libraries and electronic databases where it was placed by the Editorial Board, in cases of detection of violations of the ethics of the authors and researchers, without any compensation for the losses of the Co-authors. At the time of submission of the manuscript to the Editorial Board and all stages of its editing and review, the manuscript must not have already been published or submitted to other editorial offices.<br>12. The right transferred under this Agreement extends to the territory of Ukraine and foreign countries.<br>13. The rights of Co-authors include the requirement to indicate their names on all copies of the Work or during any public use or public mention of the Work; the requirement to preserve the integrity of the Work; legal opposition to any distortion or other encroachment on the Work, which may harm the honor and reputation of the Co-authors.<br>14. Co-authors have the right to control their personal non-property rights by familiarizing themselves with the text (content) and form of the Work before its publication on the University's website, when transferring it to a printing company for reproduction or when using the Work in other ways.<br>15. The Co-authors, in addition to the property rights not transferred under this Agreement and taking into account the non-exclusive nature of the rights transferred under this Agreement, retain the property rights to finalize the Work and to use certain parts of the Work in other works created by the Co-authors.<br>16. The Co-authors are obliged to notify the Editorial Board of all errors in the Work, discovered by them independently after the publication of the Work, and to take all measures to eliminate such errors as soon as possible.<br>17. The University undertakes to indicate the names of the Co-authors on all copies of the Work during any public use of the Work. The list of Co-authors may be shortened according to the rules for the formation of bibliographic descriptions determined by the University or third parties.<br>18. The University undertakes not to violate the integrity of the Work, to agree with the Corresponding Author on all changes made to the Work during processing and editing.<br>19. In case of violation of their obligations under this Agreement, its parties bear the responsibility defined by this Agreement and the current legislation of Ukraine. All disputes under the Agreement are resolved through negotiations, and if the negotiations do not resolve the dispute – in the courts of the city of Kharkiv.<br>20. The parties are not responsible for the violation of their obligations under this Agreement, if it occurred through no fault of theirs. The party is considered innocent if it proves that it has taken all measures dependent on it for the proper fulfillment of the obligation.<br>21. The Co-authors are responsible for the truthfulness of the facts, quotes, references to legislative and regulatory acts, other official documentation, the scientific validity of the Work, all types of responsibility to third parties who have claimed their rights to the Work. The co-authors reimburse the University for all costs caused by claims of third parties for infringement of copyright and other rights to the Work, as well as additional material costs related to the elimination of identified defects. </span></p> ic.journal@knmu.edu.ua (Alexander Shevchenko / Олександр Шевченко) admin@inter.knmu.edu.ua (Inter Collegas Support) Mon, 30 Jun 2025 00:00:00 +0300 OJS 3.1.2.1 http://blogs.law.harvard.edu/tech/rss 60 Liraglutide as a means of modifying cardiometabolic risk in patients with arterial hypertension and concomitant obesity https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.2.dun <p><strong>In press</strong></p> <p><strong>Background.</strong> Arterial Hypertension (AH), in combination with OBesity (OB), significantly increases cardiometabolic risk, leading to the development of cardiovascular events, chronic kidney disease, and metabolic disorders. In such patients, the effectiveness of standard antihypertensive therapy may be insufficient, which requires the use of drugs with pleiotropic action.</p> <p><strong>Aim.</strong> To assess the effectiveness of liraglutide, Glucagon-Like Peptide-1 Receptors Agonist (GLP-1RA), as a component of combination therapy in patients with AH and OB, with the determination of its effect on cardiometabolic status, functional state of the kidneys, heart and neurohumoral regulation.</p> <p><strong>Materials and Methods.</strong> The study involved 62 patients with AH and OB who received liraglutide at a dose of up to 3.0 mg/day for 12 months. The dynamics of anthropometric, biochemical, hormonal, hemodynamic, and echocardiographic parameters were assessed. Statistical processing was performed using the Statistica 13.0 package (StatSoft Inc., USA).</p> <p><strong>Results.</strong> During the treatment, a significant decrease in systolic and diastolic blood pressure, body mass index, insulin levels, leptin, Cardiotrophin-1 (CTF-1), N-terminal propeptide of brain natriuretic hormone (NT-proBNP), as well as an improvement in the lipid profile were observed. According to echocardiography, regression of myocardial hypertrophy and improved systolic and diastolic function of the left ventricle was recorded. Positive but insignificant dynamics of functional renal parameters were noted.</p> <p><strong>Conclusions.</strong> Liraglutide demonstrates a pronounced multicomponent efficacy in patients with hypertension and obesity, reducing leptin resistance and improving neuroendocrine regulation and metabolic and hemodynamic profile. Our findings suggest that it can be used in complex therapy to modify cardiometabolic risk.</p> <p><em><strong>Keywords:</strong></em><em> leptin, GLP-1RA, N-terminal propeptide of brain natriuretic hormone, cardiohemodynamics.</em></p> I.P. Dunaieva Copyright (c) 2025 Dunaieva I.P. https://creativecommons.org/licenses/by-nc-sa/4.0/ https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.2.dun Tue, 01 Apr 2025 00:00:00 +0300 Statistical characteristics of groups of elderly patients with gonarthrosis against the background of overweight or obesity https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.2.hrd <p><strong>In press</strong></p> <p><strong>Background.</strong> The aging of the population, the prevalence of gonarthrosis, and the the epidemic of overweight highlight the relevance of the study.</p> <p><strong>Aim</strong>. To determine the effectiveness of the treatment algorithm for persons of older age groups with gonarthrosis of the II–III degree and functional insufficiency of the I–II degree, excessive body weight in the conditions of martial law by means of statistical processing of the obtained results.</p> <p><strong>Materials and Methods.</strong> The study continued during 2022–2025 in the polyclinic of the Municipal Non-Profit Enterprise of the Kharkiv Regional Council "Regional Clinical Hospital". 100 older patients with gonarthrosis of II–III degree and functional insufficiency of I–II degree, and overweight, who were divided into three groups according to treatment tactics, were examined. Group I and Group II patients received oral chondroprotectors and used articulated orthoses. After 3 months, patients of Group I were injected with hyaluronic acid intra-articularly during a follow-up examination. Patients in all groups received topical and oral non-steroidal anti-inflammatory drugs. All patients signed a consent to participate in the study. Statistical processing of the Lequesne index and Western Ontario &amp; McMaster Universities Osteoarthritis index was carried out using SPSS 27 (IBM, USA).</p> <p><strong>Results and Conclusions.</strong> According to the Kolmogorov-Smirnov criterion, the normal distribution of the studied indicators was confirmed.&nbsp; Combined treatment of patients of Group I (orthoses, chondroprotectors and hyaluronic acid) proved to be statistically and clinically effective in older patients with gonarthrosis of II–III degree and functional insufficiency of I–II degree against the background of overweight. Group II patients needed further optimization of treatment, and Group III – active intervention. The results obtained were similar to some foreign and domestic studies.</p> <p><em><strong>Keywords:</strong> degenerative-dystrophic diseases, body mass index, Lequen index, Western Ontario &amp; McMaster Universities Osteoarthritis index.</em></p> V.V. Hryhoruk, D.A. Davidenko Copyright (c) 2025 Hryhoruk V.V., Davidenko D.A. https://creativecommons.org/licenses/by-nc-sa/4.0/ https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.2.hrd Tue, 01 Apr 2025 00:00:00 +0300 Role of nursing interventions in preventing postoperative complications https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.2.huk <p><strong>In press</strong></p> <p><strong>Background. </strong>Postoperative complications refer to pathological conditions that deviate from the normal course of the postoperative period and are not a consequence of the progression of the underlying disease.</p> <p><strong>Aim. </strong>To analyze the number of nursing interventions in the postoperative period aimed at preventing complications, as well as to evaluate the results of a patient survey regarding the nurse's role in postoperative care.</p> <p><strong>Materials &amp; Methods. </strong>This study is based on an analysis of the number of nursing interventions performed in the postoperative period. A total of 2,913 patients underwent surgical interventions on abdominal organs for conditions such as cholelithiasis, appendicitis, acute intestinal obstruction, hernia, acute pancreatitis, and perforated gastric or duodenal ulcers. The survey included 65 patients from the surgical department. Its purpose was to assess the role of nurses in caring for patients after abdominal surgery (35 (53.8%) men and 30 (46.2%) women).</p> <p><strong>Results. </strong><strong>&nbsp;</strong>One hundred percent of nurses fulfill doctors' prescriptions, 96.9% prepare patients for diagnostic and treatment procedures, and 95.4% assist with personal hygiene. Additionally, 96.9% of patients expressed satisfaction with the work of nurses. In the future, the focus will be on identifying the main types of postoperative complications and their causes, as well as formulating measures aimed at preventing such complications</p> <p><strong>Conclusions.</strong> It was found that nurses play an very important role in providing care to patients after abdominal surgery. The nurse is the closest assistant to the doctor, and the success of treatment often depends on her. Correct and timely implementation of medical prescriptions, as well as a compassionate attitude towards the patient, create conditions for a speedy recovery. In the future, the focus will be on identifying the main types of postoperative complications and their causes, as well as formulating measures aimed at preventing such complications.</p> <p><strong><em>Keywords</em></strong><em>: </em><em>nurse</em><em>,</em><em> abdominal surgery</em><em>, </em><em>postoperative care</em><em>. </em></p> A.A. Huk, G.V. Yeryomenko Copyright (c) 2025 Huk A.A., Yeryomenko G.V. https://creativecommons.org/licenses/by-nc-sa/4.0/ https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.2.huk Tue, 01 Apr 2025 00:00:00 +0300 Importance of infection control in increasing patient safety and preventing infections during healthcare (literature review) https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.2.krg <p><strong>In press</strong></p> <p><strong>Background</strong>. Today, the topic of combating Healthcare-Associated Infections (HAIs) is becoming increasingly relevant. The World Health Organization has developed the concept of Infection Prevention and Control (IPC), which is a key component of quality control and patient safety in hospitals.</p> <p><strong>Aim. </strong>To analyze modern methods of infection prevention and the role of healthcare workers in the effective implementation of infection control measures, according to the data of modern literature sources.</p> <p><strong>Materials and Methods. </strong>We analyzed the literature on prevention of hospital-acquired infections, as well as the importance of infection control in improving patient safety, the role of medical staff in the provision of medical care. The search for scientific information was carried out using the scientific databases Scopus, PubMed, Web of Science, Google Scholar.</p> <p><strong>Results &amp; Conclusions. </strong>Hospital-acquired infections are a serious public health problem associated with increased patient morbidity and mortality, as well as an economic burden on healthcare systems. Approximately 10% of hospitalized patients in high-income countries are affected by HAIs. Infection control is defined as a set of effective organizational, preventive and anti-epidemic measures aimed at preventing the occurrence and spread of healthcare-associated infections. Healthcare workers play an important role in the effective implementation of infection control measures. The use of Personal Protective Equipment (PPE), hand hygiene, environmental cleaning, screening and isolation, sterilization and disinfection, surveillance and reporting, vaccination and the introduction of innovative technologies in hospital infection control are important elements of the prevention and control of HAIs. Hospital infection control is essential to protect patients, healthcare workers and the wider community from HAIs. These measures are important to protect patients, healthcare workers and all society.</p> <p><em><strong>Keywords:</strong> hand hygiene, healthcare-associated infections, infection prevention<strong>.</strong></em></p> K.O. Krasovska, N.I. Globina Copyright (c) 2025 Krasovska K.O., Globina N.I. https://creativecommons.org/licenses/by-nc-sa/4.0/ https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.2.krg Tue, 01 Apr 2025 00:00:00 +0300 The role of the nurse in the cervical screening procedure in women of reproductive age https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.2.lbo <p><strong>In press</strong></p> <p>The implementation of systematic cervical screening programs significantly reduces the incidence and mortality of cervical cancer, which is proven by the experience of countries with developed screening systems. This short scientific report highlights the role of a nurse in the process of cervical screening in women of reproductive age as a key link in the system of early detection of cervical cancer. Attention is focused on the importance of nursing intervention not only at the stage of biomaterial collection, but also in the process of informing, counseling, psychological support of patients, keeping records and monitoring repeated screening. Modern approaches to screening are analyzed, in particular, Papanicolaou test, human papillomavirus testing, co-testing, as well as the organizational component of nursing work. It is emphasized that timely detection of precancerous conditions is possible provided that the nurse's work is professionally performed, quality standards are observed and the female population is regularly covered by preventive programs. Thus, nurses perform key functions in the implementation of cervical screening programs, providing organizational support, information and educational work with the population, direct screening procedures and further monitoring of patients. Expanding the powers of nurses and developing their competencies in the field of cervical screening allows solving the problem of staff shortage, increasing the availability of preventive services and ensuring timely detection of precancerous changes in the cervix. Improving the training of nurses and standardizing their activities in the field of cervical screening creates the basis for full use of the potential of paramedical personnel in the prevention of cervical cancer. The implementation of a structured approach to organizing the work of nurses during cervical screening will ensure an increase in the overall effectiveness of screening programs and an expansion of coverage of target population groups.</p> <p><strong><em>Keywords: </em></strong><em>prevention, cervical cancer, Papanicolaou test, human papillomavirus, women's health</em><em>.</em></p> K.V. Lutsenko, E.O. Bolokadze Copyright (c) 2025 Lutsenko K.V., Bolokadze E.O. https://creativecommons.org/licenses/by-nc-sa/4.0/ https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.2.lbo Tue, 01 Apr 2025 00:00:00 +0300 Dynamics of cardiovascular diseases among Kharkiv residents during the war in 2022 and 2023 https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.2.prb <p><strong>In press</strong></p> <p><strong>Background.</strong> The full-scale invasion in Ukraine has become a serious challenge for the healthcare system, in particular for the diagnosis, treatment and prevention of cardiovascular diseases.</p> <p><strong>Aim.</strong> To investigate the peculiarities of the prevalence of cardiovascular disease in Kharkiv residents in wartime, in 2022 and 2023.</p> <p><strong>Materials and Methods.</strong> The study used medical-statistical and comparative methods. Data from the Center for Medical Statistics of the Public Health Center of the Ministry of Health of Ukraine on cardiovascular pathology were analyzed. The comparison was based on absolute rates of morbidity due to the lack of reliable data on the number of the existing population during the war.</p> <p><strong>Results</strong> <strong>and Conclusions</strong>. The number of registered cases of hypertension increased from 192,919 to 211,214 cases from 2022 and 2023, which corresponds to an absolute increase of 18,295 cases (9.5%). Angina pectoris demonstrated an increase in the number of reported cases from 46,844 in 2022 to 54,850 in 2023, which is an increase of 8,006 cases (17.1%). The analysis of the prevalence of acute myocardial infarction also showed a negative trend. In 2022, 977 cases were registered, while in 2023 there were already 1,176 cases, which is an increase of 199 cases (20.4%). The prevalence of strokes also shows an upward trend – in 2022; 1,630 cases were reported, and in 2023; 1,857 cases were reported, an increase of 227 cases (13.9%). We attribute the increase in the number of cases of cardiovascular diseases to the influence of stress factors, changes in lifestyle, worsening access to medical care, worsening socio-economic living conditions of the population in war-affected regions, insufficient physical activity, sleep disorders (apnea). In addition, an important factor could be the restriction of preventive measures and medical examinations due to wartime conditions, which led to untimely detection and treatment of pathologies in the early stages.</p> <p><em><strong>Keywords</strong>: martial law, hypertension, angina pectoris, acute myocardial infarction, strokes.</em></p> N. Pryima, T. Bezditko Copyright (c) 2025 Pryima N., Bezditko T. https://creativecommons.org/licenses/by-nc-sa/4.0/ https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.2.prb Tue, 01 Apr 2025 00:00:00 +0300 Vasyl Yakovych Danylevskyi's lecture on a doctor at work, his worldview, responsibility and professional freedom (1921): Annotated translation https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.2.bsk <p><strong>In press</strong></p> <p>A physician must possess certain qualities of intellect and character, certain natural qualities, firm principles and bitter life experience in order to choose the right paths of work and behavior. In an era of social and political upheavals, the number of weak-willed people with antisocial behavior increases. A physician as a practicing psychologist often has to act both in public life and in his daily work with a patient. No less important is the physician's work in the field of hygiene and prevention. An enlightened mind is the basis of social happiness. To restore the disturbed balance of spirit, there is a need for intellectual or artistic pleasure. For a practicing physician, it is necessary to form a general scientific worldview in order not to scatter and fragment knowledge. The deontological attitude of a physician includes many complex and delicate issues, in addition to the physical, moral and mental side. The most difficult problems that a physician faces are the patient's attitude to death, issues of eugenics, abortion, euthanasia. A physician has to bear responsibility not only for his actions, but also for his words. But only doctors can judge a doctor not only from a professional point of view, but also from a moral and social point of view. For the future of medical activity, the solution to the question is of great importance: will it remain a free profession or will it turn entirely into a mandatory service occupation. The progress of medicine cannot be separated from the general course of cultural development of society. A doctor stands above all political, social, economic trends, for he deals with a person without distinction of tribes, dialects, conditions. We are so accustomed to the everyday actions of a doctor that we stop noticing and appreciating his outstanding merits, selfless help to the wounded and sick. Go boldly on the path of serving truth, justice and goodness, fulfill the covenants of humanist doctors and in the consciousness of the rightness of your cause you will draw strength for your difficult and responsible work.</p> <p><strong><em>Keywords:</em></strong> <em>deontology, education, personality, society, medical art.</em></p> O.M. Biletska, A.S. Shevchenko, I.V. Korneyko, G.I. Gubina-Vakulik, S.I. Latohuz, I.A. Polonnik, Ye.I. Voroshylova, O.S. Hurbych Copyright (c) 2025 Biletska O.M., Shevchenko А.S., Korneyko I.V., Gubina-Vakulik G.I., Latohuz S.I., Polonnik I.A., Voroshylova Ye.I., Hurbych O.S. https://creativecommons.org/licenses/by-nc-sa/4.0/ https://inter.knmu.edu.ua/article/view/10.35339.ic.2025.12.2.bsk Wed, 28 May 2025 00:00:00 +0300