THE CHANGES OF MARKERS OF ENERGY HOMEOSTASIS, ADIPOKINES, CARBOHYDRATE METABOLISM IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION ACCOMPANIED BY OBESITY
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Keywords

adipokines, carbohydrate metabolism, acute myocardial infarction, energy homeostasis, obesity.

How to Cite

Koteliukh, M. (2021). THE CHANGES OF MARKERS OF ENERGY HOMEOSTASIS, ADIPOKINES, CARBOHYDRATE METABOLISM IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION ACCOMPANIED BY OBESITY. Inter Collegas, 7(4), 168–173. https://doi.org/10.35339/ic.7.4.168-173

Abstract

Background. Obesity is associated with changes in energy homeostasis (irisin and adipokine) and the adipokine system (FABP 4 and CTRP 3) and the impact on the development and course of cardiovascular diseases.

The purpose of the study. To investigate the time course of markers of energy homeostasis, adipokines and carbohydrate metabolism and their relationship in patients with acute myocardial infarction with the presence and absence of comorbid pathology.

Materials and methods. The study involved examination of 189 patients with acute myocardial infarction with the presence and absence of obesity. The control group included 20 practically healthy subjects. Adropin, irisin, FABP 4, CTRP 3, insulin were determined by enzyme-linked immunosorbent assay.

Results of the study. All groups of patients in the time course of observation were found to have a decrease in levels of glucose, insulin, HOMA index (p˂0.05). An increase in adropin, irisin and CTRP 3 and a decrease in FABP 4 in all groups of patients compared with patients by 1-2 days (p˂0.05) were determined on day 10. The relationship between carbohydrate metabolism and adropin, irisin, FABP 4, CTRP 3 in all groups of patients on days 1-2.

Conclusion. Our findings indicate that the markers of energy homeostasis and adipokine system influence the state of carbohydrate metabolism in patients with acute myocardial infarction with concomitant obesity was determined.

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https://doi.org/10.35339/ic.7.4.168-173
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References

Akcilar, R., Emel Kocak, F., Simsek, H., Akcilar, A., Bayat, Z., Ece, E., Kokdasgil, H. (2016). Theeffect of adropin on lipid and glucose metabolism in rats with hyperlipidemia. Iranian Journal of Basic Medical Sciences, 19 (3), 245–251.

Arhiv derzhavnoyi statistiki Ukrayini. (2020). [Archive of State Statistics of Ukraine]. Retrieved from: http://www.ukrstat.gov.ua/operativ/operativ2020/ds/kpops/kpops_u/arh_kpops2020_u.html

Aronis, K.N., Moreno, M., Polyzos, S.A., Moreno-Navarrete, J.M., Ricart, W., Delgado, E., … Mantzoros, C.S. (2015). Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events. Int J Obes (Lond), 39, 156–161.

Aydin, S. (2014). Three new players in energy regulation: preptin, adropin and irisin. Peptides, 56, 94–110. doi: 10.1016/j.peptides.2014.03.021.

Fisher, R.M., Eriksson, P., Hoffstedt, J., Hamsten, A., Arner, P. (2000). Fatty acid binding proteinsin different human adipose tissue depots: Relationships to serum insulin concentrations. Atherosclerosis, 151 (1), 79. https://doi.org/10.1016/S0021-9150(00)80359-7

Furuhashi, M. (2019). Fatty acid-binding protein 4 in cardiovascular and metabolic diseases. J Atherosclerosis Thromb, 26, 216–232. doi: 10.5551/jal.48710.

Hofmann, C., Chen, N., Obermeier, F., Paul, G., Buchler, C., Kopp, A., … Schaffler, A. (2011). C1q/TNF-related protein-3 (CTRP-3) is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts. Inflammatory Bowel Diseases, 17 (12), 2462–2471.

Ishimura, S., Furuhashi, M., Watanabe, Y., Hoshina, K., Fuseya, T., Mita, T., … Miura, T. (2013). Circulating levels of fatty acid-binding protein family and metabolic phenotype in the general population. PLoS One, 8 (11), 813–18.

Iso T., Maeda K., Hanaoka H., Suga T., Goto K., Syamsunarno Mas Rizky A.A, … Kurabayashi M.(2013). Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle. Arterioscler Thromb Vasc Biol, 33(112, 2549-2557. doi: 10.1161/ATVBAHA.113.301588.

Jasaszwili, M., Billert, M., Strowski, M. Z., Nowak, K.W., Skrzypski, M. (2020). Adropin as a fat- burning hormone with multiple functions-review of a decade of research. Molecules, 25(3), 549. doi: 10.3390/molecules25030549.

Koksharova, E.O., Majorov, A.Yu., Shestakova, M.V., Dedov, I.I. (2014). Metabolicheskieosobennosti i terapevticheskij potencial buroj i "bezhevoj" zhirovoj tkani [Metabolic characteristics and therapeutic potential of brown and "beige" adipose tissue]. Saharnyj diabet, 4, 5–15.

Kumar, K. G., Trevaskis, J. L., Lam, D. D., Sutton G. M., Koza R. A., Chouljenko V. N., … Butler, A. A. (2008). Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab, 8, 168–481. doi: 10.1016/j.cmet.2008.10.011.

Oelmann, S., Nauck, M., Volzke, H., Bahls, M., Friedrich, N. (2016). Circulating irisin concentrations are associated with a favourable lipid profile in the general population. Plos one, 11(4): e0154319. https://doi.org/10.1371/journal.pone.0154319

Rajala, M.W., Scherer, P.E. (2003). Minireview: the adipocyte-at the crossroads of energyhomeostasis, inflammation, and atherosclerosis. Endocrinology, 144 (9), 3765–3773.

Sato, K., Yamashita, T., Shirai, R., Yamashita, T., Shibata, K. (2018). Adropin contributes to antiatherosclerosis by suppressing monocyte-endothelial cell adhesion and smooth muscle cell proliferation. International journal of molecular sciences, 19(5), 1293.

Scherer, P. E. (2006). Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes, 55 (6), 1537–1545.

Vavilova, T. P., Pleten, A. P., Miheev, R. K. (2017). Biologicheskaya rol adipokinov kak markerov patologicheskih sostoyanij. [Biological role of adipokines as markers of pathological conditions]. Voprosy pitaniya, 86(2), 5–13.

Wu, L. E., Samocha-Bonet, D., Whitworth, P. T., Fazakerley, D. (2014). Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity. Molecular metabolism, 3, 465–473.

Yumuk, V., Tsigos, C., Fried, M., Schindler, K., Busetto, L., Micic, D., Toplak, H. (2015). Europeanguidelines for obesity management in adults. Obesity facts, 8, 402–424. doi: 10.1159/000442721.

Zhilcov, I., Semenov, V., Zenkova, S. (2014). Osnovy medicinskoj statistiki. Dizajn biomedicinskihissledovanij: prakticheskoe rukovodstvo [Fundamentals of Medical Statistics. Biomedical Research Design: A Practical Guide]. Vitebsk: VGMU.

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