TOLL-LIKE RECEPTORS AND THEIR ROLE IN THE PATHOGENESIS OF PSORIASIS

Abstract

Abstract

Dashchuk A.M., Pochernina V.V.

TOLL-LIKE RECEPTORS AND THEIR ROLE IN THE PATHOGENESIS OF PSORIASIS

Kharkiv National Medical University, Ukraine

 

The study deals with determination of the role of TOLL-like receptors 4 and 9 in the development of psoriasis. Patients with psoriasis were shown to have an increase in production and hypersecretion of pro-inflammatory biomarkers, namely TLR4 and TLR9-positive cellsby epithelial cells. Respective TLR4 and TLR9-positive cells were detectedboth in the areas of the skin affected by psoriatic rash and in the intact skin. However, the number of the respective cells in the affected skin areas is greater than in the intact skin.

Key Words:      psoriasis, TOLL-like receptors, chronic dermatoses.

 

Резюме

Дащук А.М., Почерніна В.В.

TOLL-ПОДІБНІ РЕЦЕПТОРИ І ЇХ РОЛЬ У ПАТОГЕНЕЗІ ПСОРІАЗУ

Харківськийнаціональниймедичнийуніверситет

 

Обговорюється вивчення TOLL-подібнихрецепторів 4 і 9 типу в шкірі хворих на псоріаз (в інтактній та в ураженій шкірі). У хворих на псоріаз встановлена гіперпродукція і гіперсекреція епітеліоцитами шкіри прозапальних біологічних маркерів, зокрема TLR4 і TLR9- позитивних клітин. Відповідні TLR4 і TLR9-позитивні клітини визначаються як в уражених псоріатичними висипаннями ділянках шкіри, так і в інтактнній шкірі. Але кількість відповідних клітин в ділянках ураженої шкіри більше, ніж інтатктной.

Ключові слова: псоріаз, TOLL-подібні рецептори, хронічні дерматози.

 

 

Резюме

Дащук А.М., Почернина В.В.

TOLL-ПОДОБНЫЕ РЕЦЕПТОРЫ И ИХ РОЛЬ В ПАТОГЕНЕЗЕ ПСОРИАЗА

Харьковский национальный медицинский университет

 

Обсуждается изучение TOLL-подобных рецепторов 4 и 9 типа в коже больных псориазом. У больных псориазом установлена гиперпродукция и гиперсекреция эпителиоцитами кожи провоспалительных биологических маркеров, в частности TLR4 и TLR9- положительных клеток. Соответствующие TLR4 и TLR9-положительные клетки определяются как в пораженных псориатическими высыпаниями участках кожи, так и в интактной коже. Но количество соответствующих клеток в участках пораженной кожи больше, чем в интатктной.

Ключевые слова: псориаз, TOLL-подобные рецепторы, хронические дерматозы

https://doi.org/10.35339/ic.3.1.40-44
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