How to Cite
Abstract
Summary.
Smirnov A.S.
The impact of epichlorohydrin, Echinacea purpurea extract and thiotriazoline on the pyloric glands of the stomach in rats.
The study involving white male rats was performed to assess the pattern of epichlorohydrin action on the pyloric gland of the stomach and evaluate the possibility of Echinacea purpurea extract and thiotriazoline administration for the correction of changes developing in the pyloric glands. Prolonged epichlorohydrin inhalation was shown to trigger a decrease in the length of the pyloric glands in rats. A decrease in the length of glands occurred within thirty days after discontinuation of inhalation. Echinacea purpurea extract and thiotriazoline administration in rats not exposed to epichlorohydrin was accompanied by an increase in the length of the pyloric glands, which persisted after discontinuation of administration of each agent. Echinacea purpurea extract and thiotriazoline administration secondary to epichlorohydrin inhalation reduced the degree and duration of the effect of a decrease in the length of the pyloric glands caused by epichlorohydrin. Thiotriazoline was shown to have a more significant corrective action.
Keywords: stomach, pyloric glands, epichlorohydrin, Echinacea purpurea extract, thiotriazoline.
Резюме.
Смирнов А.С.
Вплив епіхлоргідріну, екстракту ехінацеї пурпурової і тіотриазоліну на пілоричні залози шлунка щурів.
В експериментах на білих щурах-самцях досліджували особливості дії епіхлоргідріну на пілоричні залози шлунка, оцінювали можливість використання екстракту ехінацеї пурпурової і тіотриазоліну для корекції змін, які розвиваються в пілоричних залозах. Було показано, що тривалі інгаляції епіхлоргідріну призводять до зменшення довжини пілоричних залоз шлунка щурів. Зменшення довжини залоз спостерігається протягом тридцяти діб після завершення інгаляцій. Введення екстракту ехінацеї пурпурової, а також введення тіотриазоліну щурам, на яких не впливав епіхлоргідрин, супроводжується збільшенням довжини пілоричних залоз, яке зберігається після припинення введення кожного з препаратів. Застосування як екстракту ехінацеї пурпурової, так і тіотриазоліну на тлі інгаляцій епіхлоргідріну зменшує ступінь і скорочує тривалість викликаного ним ефекту зменшення довжини пілоричних залоз. Тіотриазолін виявляє більш сильну коректуючу дію. Ключові слова: шлунок, пілоричні залози, епіхлоргідрин, екстракт ехінацеї пурпурової, тіотриазолін.
Резюме.
Смирнов А.С.
Влияние эпихлоргидрина, экстракта эхинацеи пурпурной и тиотриазолина на пилорические железы желудка крыс.
В экспериментах на белых крысах-самцах исследовали особенности действия эпихлоргидрина на пилорические железы желудка, оценивали возможность использования экстракта эхинацеи пурпурной и тиотриазолина для коррекции изменений, развивающихся в пилорических железах. Было показано, что длительные ингаляции эпихлоргидрина приводят к уменьшению длины пилорических желез желудка крыс. Уменьшение длины желез наблюдается в течение тридцати суток после завершения ингаляций. Введение экстракта эхинацеи пурпурной, а также введение тиотриазолина крысам, на которых не влиял эпихлоргидрин, сопровождается увеличением длины пилорических желез, которое сохраняется после прекращения введения каждого из препаратов. Применение как экстракта эхинацеи пурпурной, так и тиотриазолина на фоне ингаляций эпихлоргидрина уменьшает степень и сокращает продолжительность вызванного ним эффекта уменьшения длины пилорических желез. Тиотриазолин проявляет более выраженное корректирующее действие.
Ключевые слова: желудок, пилорические железы, эпихлоргидрин, экстракт эхинацеи пурпурной, тиотриазолин.
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