How to Cite
Abstract
RELATIONSHIP BETWEEN PROINFLAMMATORY AND ATHEROGENIC MARKERS AND VESSELS REMODELING IN PATIENTS WITH HYPERTENSIVE DISEASE
Kysylenko K., Kovalyova O.
Resume. The article presents clinical data that shows the relationship between proinflammatory markers (IL-22) and atherogenic markers (indices of lipid spectrum) in the formation of structural and functional changes in the carotid arteries, which can be considered as early subclinical markers of atherosclerotic vascular damage in the cohort of patients with comorbidity of hypertension and obesity. Such a combined pathology can be considered a trigger of metabolic events adversely affecting the lipid profile and directing these patients to a high cardiometabolic risk group.
Key words: atherogenesis, hypertension, interleukin-22, lipid profile, proinflammatory status, remodeling of carotid arteries.
Резюме
ЗВ’ЯЗОК ПРОЗАПАЛЬНИХ ТА АТЕРОГЕННИХ МАРКЕРІВ З РЕМОДЕЛЮВАННЯМ СУДИН У ПАЦІЄНТІВ З ГІПЕРТОНІЧНОЮ ХВОРОБОЮ
Кисиленко К., Ковальова О.
В статті наведені клінічні данні, які відображають зв'язок прозапальних маркерів (ІЛ-22) та атерогенних маркерів (показників ліпідного спектру) у формуванні структурно-фунціональних змін сонних артерій, які можна розглядати ранніми субклінічними маркерами атеросклеротичного ураження судин у когорти хворих при коморбідності ГХ та ожиріння. Таку поєднану патологію можна розглядати тригерним механізмом запуску несприятливих метаболічних подій, які негативно впливають на ліпідний профіль та спрямовують цих пацієнтів до зони високого кардіометаболічного ризику.
Ключові слова: атерогенез, гіпертонічна хвороба, інтерелейкін-22, ліпідний профіль, прозапальний статус, ремоделювання сонних артерій.
Резюме.
СВЯЗЬ ПРОВОСПАЛИТЕЛЬНЫХ И АТЕРОГЕННЫХ МАРКЕРОВ С РЕМОДЕЛИРОВАНИЕМ СОСУДОВ У ПАЦИЕНТОВ С ГИПЕРТОНГИЧЕСКОЙ БОЛЕЗНЬЮ
Кисиленко Е., Ковалёва О.
В статье приведены клинические данные, которые отображают связь провоспалительных маркеров (ИЛ-22) и атерогенных маркеров (показателей липидного профиля) в формировании структурно-функциональных изменений сонных артерий, которые можно расценивать как ранние субклинические маркеры атеросклеротического поражения сосудов у когорты больных при коморбидности гипертонической болезни и ожирения. Такую сочетанную патологию можно рассматривать триггерным механизмом запуска неблагоприятных метаболических событий, которые негативно влияют на липидный профиль и направляют этих пациентов в зону высокого кардиометаболического риска.
Ключевые слова: атерогенез, гипертоническая болезнь, интерлейкин-22, липидный профиль, провоспалительный профиль, ремоделирование сонных артерий.
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