Keywords
How to Cite
Abstract
ANAMNESTIC RISK FACTORS FOR THE FORMATION OF ASTHMA IN INFANTS
Malakhova V.
Introduction. Allergic diseases are one of the major problems of the present. Almost 700 million people in the world are suffering from this disorder. Respiratory allergies rank as some of the most common chronic health conditions among them. About 330 million people are suffering from bronchial asthma today. The aim of the study. To identify the risk factors for the development of asthma in children with wheezing.
Objective. The purpose of this study was to determine the risk factors for asthma formation. The study involved assessment of clinical data of 94 children aged 1 to 7 years with recurrent wheezing. Children were observed for 5 years. The first group included 62 patients with diagnosed acute obstructive bronchitis, and the second group included 32 patients diagnosed with asthma. Results. Assessment of anamnestic data revealed significant risk factors for the formation of asthma. The study showed a relationship between the risk factor and the development of the disease in children with recurrent wheezing. Conclusions. The obtained data can be used in the algorithm of examination of patients with wheezing. The study implied the assessment of risk factors for the formation of asthma. This is important for pediatric practice. Thorough history taking and determination of risk factors are important when examining patients with recurrent wheezing.
Keywords: wheezing, asthma, children, anamnestic data, risk factors.
Резюме
АНАМНЕСТИЧНІ ЧИННИКИ РИЗИКУ ФОРМУВАННЯ БРОНХІАЛЬНОЇ АСТМИ У ДІТЕЙ РАННЬОГО ВІКУ.
Малахова В.М.
Вступ. Алергійні захворювання являють собою одну з головних проблем сьогодення. Майже 700 мільйонів людей у світі страждають на дану патологію. Серед них респіраторні алергози займають значну частку, на даний час близько 330 мільйонів людей страждають на бронхіальну астму.
Мета дослідження. Виявити анамнестичні фактори ризику розвитку бронхіальної астми у дітей з повторними епізодами бронхообструктивного синдрому. Об’єкт і методи дослідження. Проведено аналіз клінічних даних 94 дітей у віці від 1 до 7 років з повторними епізодами бронхообструктивного синдрому. Діти знаходились під постійним динамічним спостереженням протягом 5 років з метою верифікації формування бронхіальної астми. Усім пацієнтам проведено повне дослідження згідно протокольних методик. До першої групи увійшло 62 пацієнта із встановленим діагнозом гострий обструктивний бронхіт, до другої групи увійшло 32 дитини, котрим діагностовано бронхіальну астму. Результати досліджень та їх обговорення. Серед вивчених показників анамнестичних даних виявлено статистично значимі несприятливі чинники формування бронхіальної астми та встановлено характер та силу зв’язку між факторами ризику та формуванням захворювання у дітей з повторними епізодами бронхообструктивного синдрому. Висновки. Отримані дані можуть бути включені в алгоритм обстеження пацієнтів з бронхообструктивним синдромом для об’єктивної оцінки факторів ризику та можливості формування бронхіальної астми, що надзвичайно важливо для педіатричної практики. Тому ретельний збір анамнезу та виявлення цих факторів має велике значення при ведені пацієнтів із повторними епізодами бронхообструктивного синдрому.
Ключові слова: бронхообструктивний синдром, бронхіальна астма, діти, анамнестичні дані, несприятливі чинники.
Резюме
АНАМНЕСТИЧЕСКИЕ ФАКТОРЫ РИСКА ФОРМИРОВАНИЯ БРОНХИАЛЬНОЙ АСТМЫ У ДЕТЕЙ РАННЕГО ВОЗРАСТА.
Малахова В.М.
Введение. Аллергические заболевания представляют собой одну из главных проблем современного мира. Среди них респираторные аллергозы занимают значительную часть, на данный момент около 330 миллионов людей страдают на бронхиальную астму. Цель исследования. Выявить анамнестические факторы риска развития бронхиальной астмы у детей с повторными эпизодами бронхообструктивного синдрома. Объект и методы исследования.Проведен анализ клинических данных 94 детей в возрасте от 1 до 7 лет с повторными эпизодами бронхообструктивного синдрома. Дети находились под постоянным динамическим наблюдением в течение 5 лет с целью верификации формирования бронхиальной астмы. В первую группу вошло 62 пациента с установленным диагнозом острого обструктивного бронхита, ко второй группе отнесены 32 пациента, которым установлен диагноз бронхиальной астмы. Результаты и обсуждение. Среди изученных показателей анамнестических данных выявлены статистически значимые неблагоприятные факторы формирования бронхиальной астмы, установлены характер и сила связи между факторами риска и формированием заболевания у детей с повторными эпизодами бронхообструктивного синдрома.
Ключевые слова: бронхообструктивный синдром, бронхиальная астма, дети, анамнестические данные, факторы риска.
References
Zhang JL, Ma Z, Sun WW, et al. Programmed vaccination may increase the prevalence of asthma and allergic diseases. Am J Rhinol Allergy. 2016; 30: 113-117.
Diaz-Vazquez C, Torregrosa‐Bertet MJ, Carvajal‐Uruena I, et al. Accuracy of ImmunoCAP Rapid in the diagnosis of allergic sensitization in children between 1 and 14 years with recurrent wheezing: the IReNE study. Pediatr Allergy Immunol. 2009; 20: 601-609.
Asher I, Pearce N. Global burden of asthma among children. Int J Tuberc Lung Dis. 2014; 18: 1269-1278.
Hendaus MA, Jomha FA, Ehlayel M. Allergic diseases among children: nutritional prevention and intervention. Ther Clin Risk Manag. 2016; 12: 361-72.
Alagappan VK, de Boer WI, Misra VK, et al. Angiogenesis and vascular remodeling in chronic airway diseases. Cell Biochem Biophys. 2013; 67: 219-234.
Al-Shamrani A, Bagais K, Alenazi A, et al. Wheezing in children: Approaches to diagnosis and management. Int J Pediatr Adolesc Med. 2019; 6(2): 68-73.
Suruki RY, Boudiaf N, Ortega HG. Retrospective cohort analysis of healthcare claims in the United States characterizing asthma exacerbations in pediatric patients. World Allergy Organ J. 2016; 9:1-9.
Kawayama T, Kinoshita T, Matsunaga K, et al. Role of Regulatory T cells in Airway Inflammation in Asthma. Kurume Med J. 2018; 64: 45-55
The Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA) 2018. http://www.ginasthma.org/.
Bercedo-Sanz A, Lastra-Martínez L, Pellegrini-Belinchón J, et al. Wheezing and risk factors in the first year of life in Cantabria, Spain. The EISL study. Allergol Immunopathol. 2015; 43 (6): 543-552.
Kalliola S, Malmberg LP, Malmström K, et al. Airway hyperresponsiveness in young children with respiratory symptoms: A five-year follow-up. Ann Allergy Asthma Immunol. 2019; 122(5): 492-497.
Beigelman A, Bacharier LB. Management of preschool recurrent wheezing and asthma: a phenotype-based approach. Curr Opin Allergy Clin Immunol. 2017; 17(2): 131-138.
Chogtu B, Bhattacharjee D, Magazine R. Epigenetics: The New Frontier in the Landscape of Asthma. Scientifica. 2016; doi:10.1155/2016/4638949.
de Sousa RB, Medeiros D, Sarinho E., et al. Risk factors for recurrent wheezing in infants: a case-control study. Rev Saude Publica. 2016; 15: doi: 10.1590/S1518-8787.2016050005100.
Belhassen M, De Blic J, Laforest L, et al. Recurrent Wheezing in Infants: A Population-Based Study. Medicine (Baltimore). 2016; 95(15): e3404. doi: 10.1097/MD.0000000000003404.
Beigelman A, Bacharier LB. Management of Preschool Children with Recurrent Wheezing: Lessons from the NHLBI's Asthma Research Networks. J Allergy Clin Immunol Pract. 2016; 4(1): 1-8.
Pérez-Yarza EG, Moreno-Galdó A, Ramilo O, et al. Risk factors for bronchiolitis, recurrent wheezing, and related hospitalization in preterm infants during the first year of life. Pediatr Allergy Immunol. 2015; 26(8):797-804.
Hallit S, Leynaert B, Delmas MC, et al. Wheezing phenotypes and risk factors in early life: The ELFE cohort. PLoS One. 2018; 13(4): e0196711. doi: 10.1371/journal.pone.0196711.
Yang YZ, Cai MY, Zhang BZ, et al. Risk factors for recurrent wheezing in infants and young children suffering from dust mite allergy after their first wheezing. Zhongguo Dang Dai Er Ke Za Zhi. 2016; 18(12): 1259-1263.
Srisingh K, Weerakul J, Srijuntongsiri S, et. al. Risk Factors of Recurrent Wheezing in Children Under 5 Years of Age. J Med Assoc Thai. 2017; 100(2):183-189.
Jartti T, Gern JE. Role of viral infections in the development and exacerbation of asthma in children. J Allergy Clin Immunol. 2017; 140(4):895-906.
"Inter Collegas" is an open access journal: all articles are published in open access without an embargo period, under the terms of the CC BY-NC-SA (Creative Commons Attribution ‒ Noncommercial ‒ Share Alike) license; the content is available to all readers without registration from the moment of its publication. Electronic copies of the archive of journals are placed in the repositories of the KhNMU and V.I. Vernadsky National Library of Ukraine.
Copyright Agreement
1. This Agreement on the transfer of rights to use the work from the Co-authors to the publisher (hereinafter the Agreement) is concluded between all the Co-authors of the work, represented by the Corresponding Author, and Kharkiv National Medical University (hereinafter the University), represented by an authorized representative of the Editorial Board of scientific journals (hereinafter the Editorial Board).
2. This Agreement is an accession agreement within the meaning of clause 1 of Article 634 of the Civil Code of Ukraine: that is, a contract, "the terms of which are established by one of the parties in forms or other standard forms, which can be concluded only by joining the other party to the proposed contract as a whole. The other party cannot offer its terms of the contract." The party that established the terms of this contract is the University.
3. If there is more than one author, the authors choose the Corresponding Author, who communicates with the Editorial Board on his own behalf and on behalf of all Co-authors regarding the publication of a written work of a scientific nature (article or review, hereinafter referred to as the Work).
4. The contract begins from the moment of submission of the manuscript of the Work by the Corresponding Author to the Editorial Board, which confirms the following:
4.1. all Co-authors of the Work are familiar with and agree with its content, at all stages of reviewing and editing the manuscript and the existence of the published Work;
4.2. all Co-authors of the Work are familiar with and agree to the terms of this Agreement.
5. The published Work is in electronic form in public access on the websites of the University and any websites and electronic databases in which the Work is posted by the University and is available to readers under the terms of the "Creative Commons" license (Attribution NonCommercial Sharealike 4.0 International)" or more free licenses "Creative Commons 4.0".
6. The Corresponding Author transfers, and the University receives, the non-exclusive property right to use the Work by placing the latter on the University's websites for the entire term of copyright. The University participates in the creation of the final version of the Work by reviewing and editing the manuscript of the article or review provided to the Editorial Board by the Corresponding Author, translating the Work into any languages. For the participation of the University in the finalization of the Work, the Co-authors agree to pay the invoice issued to them by the University, if such payment is provided by the University. The size and procedure of such payment are not the subject of this contract.
7. The University has the right to reproduce the Work or its parts in electronic and printed forms, to make copies, permanent archival storage of the Work, distribution of the Work on the Internet, repositories, scientometric databases, commercial networks, including for monetary compensation from third parties.
8. The co-authors guarantee that the manuscript of the Work does not use works whose copyright belongs to third parties.
9. The authors of the Work guarantee that at the time of submission of the manuscript of the Work to the Editorial Board, the property rights to the Work belong only to them, neither in whole nor in part have they been transferred to anyone (not alienated), they are not the subject of a lien, litigation or claims by third parties.
10. The Work may not be posted on the University's website if it violates a person's right to the privacy of his personal and family life, harms public order and health.
11. The work may be withdrawn by the Editorial Board from the University websites, libraries and electronic databases where it was placed by the Editorial Board, in cases of detection of violations of the ethics of the authors and researchers, without any compensation for the losses of the Co-authors. At the time of submission of the manuscript to the Editorial Board and all stages of its editing and review, the manuscript must not have already been published or submitted to other editorial offices.
12. The right transferred under this Agreement extends to the territory of Ukraine and foreign countries.
13. The rights of Co-authors include the requirement to indicate their names on all copies of the Work or during any public use or public mention of the Work; the requirement to preserve the integrity of the Work; legal opposition to any distortion or other encroachment on the Work, which may harm the honor and reputation of the Co-authors.
14. Co-authors have the right to control their personal non-property rights by familiarizing themselves with the text (content) and form of the Work before its publication on the University's website, when transferring it to a printing company for reproduction or when using the Work in other ways.
15. The Co-authors, in addition to the property rights not transferred under this Agreement and taking into account the non-exclusive nature of the rights transferred under this Agreement, retain the property rights to finalize the Work and to use certain parts of the Work in other works created by the Co-authors.
16. The Co-authors are obliged to notify the Editorial Board of all errors in the Work, discovered by them independently after the publication of the Work, and to take all measures to eliminate such errors as soon as possible.
17. The University undertakes to indicate the names of the Co-authors on all copies of the Work during any public use of the Work. The list of Co-authors may be shortened according to the rules for the formation of bibliographic descriptions determined by the University or third parties.
18. The University undertakes not to violate the integrity of the Work, to agree with the Corresponding Author on all changes made to the Work during processing and editing.
19. In case of violation of their obligations under this Agreement, its parties bear the responsibility defined by this Agreement and the current legislation of Ukraine. All disputes under the Agreement are resolved through negotiations, and if the negotiations do not resolve the dispute – in the courts of the city of Kharkiv.
20. The parties are not responsible for the violation of their obligations under this Agreement, if it occurred through no fault of theirs. The party is considered innocent if it proves that it has taken all measures dependent on it for the proper fulfillment of the obligation.
21. The Co-authors are responsible for the truthfulness of the facts, quotes, references to legislative and regulatory acts, other official documentation, the scientific validity of the Work, all types of responsibility to third parties who have claimed their rights to the Work. The co-authors reimburse the University for all costs caused by claims of third parties for infringement of copyright and other rights to the Work, as well as additional material costs related to the elimination of identified defects.