patients with cognitive impairment, depressive disorders, clinical and psychopathological features, recurrent depressive disorder, bipolar depressive disorder, prolonged depressive reaction.


362 patients with cognitive impairment at depressive disorders were examined, of them 123 patients with recurrent depressive disorder (RDD), 141 patients with bipolar affective disorder (BAD) and 98 patients with prolonged depressive reaction (PDR). Differentiated clinical and psychopathological features of patients with cognitive impairment at depressive disorders were established: 1) combination of apathetic-adynamic, astheno-energetic and anxious symptom complexes;  predominance of moderate and major depressive episodes;  severity of apathy, subjective and objective signs of depression,  decrease in concentration and ability to feel were determined in patients with RDD; 2) combination of astheno-energetic, apathetic-adynamic, and melancholic symptom complexes;  predominance of moderate and major depressive episodes; the severity of apathy, subjective signs of depression, suicidal thoughts, insomnia and  decrease in concentration  in patients with BAD; 3) combination of anxious and apathetic-adynamic symptom complexes; the predominance of moderate and minor depressive episodes; the severity of internal stress, apathy, suicidal thoughts and loss of appetite  in patients with PDR.


Comprehensive mental health action plan 2013-2020 (2013). [Electronic resource]. Geneva: WHO, 2013. Retrieved from: (Russian)

Eschweiler, G. W. (2017). Diagnostik und multimodale Therapie der Altersdepression: Diagnostics and multimodal treatment of depression in old age. Zeitschrift fur Gerontologie und Geriatrie, 50(2); 99– 105. DOI: 10.1007/s00391-016-1174-2.

Maslow, G. R., Dunlap K., Chung R. J. (2015) Depression and Suicide in Children and Adolescents. Pediatr Rev 36(7), 299–308; quiz 9-10. Epub 2015/07/03. DOI: 10.1542/pir.36-7-299.

McIntyre , R. S., Lophaven , S., Olsen , C. K. (2014). A randomized, double-blind, placebocontrolled study of vortioxetine on cognitive function in depressed adults. Int J Neuropsychopharmacol, 17(10), 1557–1567.

Maruta, N. O., Panko, T. V. Kalenska, G. Yu. (2017). Diagnostic criteria for depressive disorders at stages of providing medical aid. Ukrainian Newsletter of Psychoneurology, 25, 1(90), 135. (Ukr.)

Cotrena, C., Branco, L. D., Shansis, F. M. & Fonseca, R. P. (2016) Executive function impairmentsin depression and bipolar disorder: association with functional impairment and quality of life. J. Affect. Disord, 190, 744–753.

Olvet, D. M., Klein, D. N. & Hajcak, G. (2010). Depression symptom severity and errorrelated brain activity. Psychiatry Res. 179, 30–37.

Snyder, H. R. (2013). Major depressive disorder is associated with broad impairments on neuropsychological measures of executive function: a meta-analysis and review. Psychological Bull, 139, 81–132.

Practice Guideline for the treatment of patients with major depressive disorder. 3rd ed. Arlington,VA: American Psychiatric Association, 2010.

McIntyre, R. S., Cha, D. S., Soczynska, J. K. et al. (2013) Cognitive deficits and functional outcomes in major depressive disorder: determinants, substrates, and treatment interventions. Depress. Anxiety, 30(6) 515–527.,

Zuckerman, H., et al. (2018). Recognition and treatment of cognitive dysfunction in major depressive disorder. Front. Psychiatry, 9, 655.

McKnight, P. E., Kashdan, T. B. (2009). The importance of functional impairment to mental health outcomes: a case for reassessing our goals in depression treatment research. Clin. Psychol. Rev., 29(3), 243–259.

Montgomery, S. A., Asberg, M. (1979). A new depression scale designed to be sensitive to change. Br J. Psychiatry, 13(4), 382-389.

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