Background. Obesity is associated with changes in energy homeostasis (irisin and adipokine) and the adipokine system (FABP 4 and CTRP 3) and the impact on the development and course of cardiovascular diseases.
The purpose of the study. To investigate the time course of markers of energy homeostasis, adipokines and carbohydrate metabolism and their relationship in patients with acute myocardial infarction with the presence and absence of comorbid pathology.
Materials and methods. The study involved examination of 189 patients with acute myocardial infarction with the presence and absence of obesity. The control group included 20 practically healthy subjects. Adropin, irisin, FABP 4, CTRP 3, insulin were determined by enzyme-linked immunosorbent assay.
Results of the study. All groups of patients in the time course of observation were found to have a decrease in levels of glucose, insulin, HOMA index (p˂0.05). An increase in adropin, irisin and CTRP 3 and a decrease in FABP 4 in all groups of patients compared with patients by 1-2 days (p˂0.05) were determined on day 10. The relationship between carbohydrate metabolism and adropin, irisin, FABP 4, CTRP 3 in all groups of patients on days 1-2.
Conclusion. Our findings indicate that the markers of energy homeostasis and adipokine system influence the state of carbohydrate metabolism in patients with acute myocardial infarction with concomitant obesity was determined.
Akcılar, R., Emel Kocak, F., Simsek, H., Akcılar, A., Bayat, Z., Ece, E., Kokdasgil, H. (2016). The effect of adropin on lipid and glucose metabolism in rats with hyperlipidemia. Iranian Journal of Basic Medical Sciences, 19 (3), 245-251.
Arhiv derzhavnoyi statistiki Ukrayini. (2020). [Archive of State Statistics of Ukraine]. Retrieved from http://www.ukrstat.gov.ua/operativ/operativ2020/ds/kpops/kpops_u/arh_ kpops 2020_u.html
Aronis, K.N., Moreno, M., Polyzos, S.A., Moreno-Navarrete, J.M., Ricart, W., Delgado, E., … Mantzoros, C.S. (2015). Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events. Int J Obes (Lond), 39, 156-161.
Aydin, S. (2014). Three new players in energy regulation: preptin, adropin and irisin Peptides, 56, 94-110. doi: 10.1016/j.peptides.2014.03.021.
Fisher, R.M., Eriksson, P., Hoffstedt, J., Hamsten, A., Arner, P. (2000). Fatty acid binding proteins in different human adipose tissue depots: Relationships to serum insulin concentrations. Atherosclerosis, 151 (1). doi: https://doi.org/10.1016/S0021-9150(00)80359-7
Furuhashi, M. (2019). Fatty acid-binding protein 4 in cardiovascular and metabolic diseases. J Atherosclerosis Thromb, 26, 216-232. doi.org/10.5551/jal.48710
Hofmann, C., Chen, N., Obermeier, F., Paul, G., Buchler, C., Kopp, A., … Schaffler, A. (2011). C1q/TNF-related protein-3 (CTRP-3) is secreted by visceral adipose tissue and exerts antiinflammatory and antifibrotic effects in primary human colonic fibroblasts.
Inflammatory Bowel Diseases, 17 (12), 2462-2471.
Ishimura, S., Furuhashi, M., Watanabe, Y., Hoshina, K., Fuseya, T., Mita, T., … Miura, T. (2013). Circulating levels of fatty acid-binding protein family and metabolic phenotype in the general population. PLoS One, 8 (11), 81318.
Iso T., Maeda K., Hanaoka H., Suga T., Goto K., Syamsunarno Mas Rizky A.A, … Kurabayashi M. (2013). Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle. Arterioscler Thromb Vasc Biol, 2549-2557. doi: 10.1161/ATVBAHA.113.301588
Jasaszwili, M, Billert, M, Strowski, MZ., Nowak, K.W., Skrzypski, M. (2020). Adropin as a fat-burning hormone with multiple functions-review of a decade of research. Molecules, 25 (3), 549. doi: 10.3390/molecules25030549.
Koksharova, E.O., Majorov, A.Yu., Shestakova, M.V., Dedov, I.I. (2014). Metabolicheskie osobennosti i terapevticheskij potencial buroj i «bezhevoj» zhirovoj tkani [Metabolic characteristics and therapeutic potential of brown and "beige" adipose tissue]. Saharnyj diabet, 4, 5-15.
Kumar, K.G., Trevaskis, J.L., Lam, D.D., Sutton G.M., Koza R.A., Chouljenko V.N., … Butler A.A. (2008). Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab, 8, 168-481. doi: 10.1016/j.cmet.2008.10.011
Oelmann S., Nauck M., Volzke H., Bahls M., Friedrich N. (2016). Circulating irisin concentrations are associated with a favourable lipid profile in the general population. Plos one. https://doi.org/10.1371/journal.pone.0154319
Rajala, M.W., Scherer, P.E. (2003). Minireview: the adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology, 144 (9), 3765-3773.
Sato K., Yamashita T., Shirai R., Yamashita T., Shibata K. (2018). Adropin contributes to anti-atherosclerosis by suppressing monocyte-endothelial cell adhesion and smooth muscle cell proliferation. International journal of molecular sciences, 19 (5), 1293.
Scherer P.E. (2006). Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes, 55 (6), 1537-1545.
Vavilova, T.P., Pleten, A.P., Miheev, R.K. (2017). Biologicheskaya rol adipokinov kak markerov patologicheskih sostoyanij. [Biological role of adipokines as markers of pathological conditions]. Voprosy pitaniya, 86 (2), 5-13.
Wu, L.E., Samocha-Bonet, D., Whitworth, P.T., Fazakerley, D. (2014). Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity. Molecular metabolism, 3, 465-473.
Yumuk, V., Tsigos, C., Fried, M., Schindler, K., Busetto, L., Micic, D., Toplak, H. (2015). European guidelines for obesity management in adults. Obesity facts, 8, 402-424. doi: 10.1159/000442721
Zhilcov, I., Semenov, V., Zenkova, S. (2014). Osnovy medicinskoj statistiki. Dizajn biomedicinskih issledovanij: prakticheskoe rukovodstvo [Fundamentals of Medical Statistics. Biomedical Research Design: A Practical Guide]. Vitebsk: VGMU
Copyright for articles published in the journal is regulated by the License Agreement for the use of a scientific article in the journal, which is concluded between the author of the article (Licensor) and Kharkov National Medical University (Licensee, publisher of the journal "Inter Collegas"). The licensor grants to the Licensee a non-exclusive non-exclusive license for the use of the article (a license that does not exclude the use of the article by the Licensor and the issuance of licenses to others for use of this article) on the terms and for the period specified in the contract. The licensor (the author of the article) grants the Licensee the right to reproduce the article (publication in the journal "Inter Collegas", publication, duplication, duplication or other reproduction of the article without limiting the circulation of copies, each copy of the article must contain the name of the Licensor; Of general information, including the publication of the article in full or in part on the Internet on the journal page, the right to use the metadata of the article (titles, full names of authors, annotations, bibliography eskih materials) through the dissemination and communication to the public, processing and systematization, as well as inclusion in various databases and in-formational system).
The licensor grants the licensee the right to transfer, store and process his personal data (full name, scientific degree, academic title, place of work and position, contact information of the authors) with the purpose of including them in the database in accordance with the Law of Ukraine No. 2297 - VI "on protection of personal data" from 01.06.2010.
Personal data and metadata of the article are provided for their storage and processing in various databases and information systems, including them in analytical and statistical reporting, creating sound relationships between the objects of works of science, literature and art with personal data, etc. on unlimited territory. The licensee has the right to transfer the specified data for processing and storage to third parties provided that such a fact is notified with the provision of information about the third party (name and address) to the Licensor.