adipokines, carbohydrate metabolism, acute myocardial infarction, energy homeostasis, obesity.


Background. Obesity is associated with changes in energy homeostasis (irisin and adipokine) and the adipokine system (FABP 4 and CTRP 3) and the impact on the development and course of cardiovascular diseases.

The purpose of the study. To investigate the time course of markers of energy homeostasis, adipokines and carbohydrate metabolism and their relationship in patients with acute myocardial infarction with the presence and absence of comorbid pathology.

Materials and methods. The study involved examination of 189 patients with acute myocardial infarction with the presence and absence of obesity. The control group included 20 practically healthy subjects. Adropin, irisin, FABP 4, CTRP 3, insulin were determined by enzyme-linked immunosorbent assay.

Results of the study. All groups of patients in the time course of observation were found to have a decrease in levels of glucose, insulin, HOMA index (p˂0.05). An increase in adropin, irisin and CTRP 3 and a decrease in FABP 4 in all groups of patients compared with patients by 1-2 days (p˂0.05) were determined on day 10. The relationship between carbohydrate metabolism and adropin, irisin, FABP 4, CTRP 3 in all groups of patients on days 1-2.

Conclusion. Our findings indicate that the markers of energy homeostasis and adipokine system influence the state of carbohydrate metabolism in patients with acute myocardial infarction with concomitant obesity was determined.



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