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Abstract
The purpose of our study was to evaluate the features of endometrial restructuring when infected with the human immunodeficiency virus.
Materials and methods: The study involved sectional material taken from 60 women of reproductive age from 20 to 40 years. Group 1 (30 women) consisted of women who were diagnosed with HIV infection. The control group comprised women (30) without concomitant HIV infection.
Results. An average diameter of the endometrial glands (proliferative type) was 8% smaller in HIV infection than in the comparison group. The minimum diameter of the endometrial glands (proliferative type) decreased by 1.73%, the maximum was 5.24% less in the HIV-infected group than in the comparison group. The wall thickness was reduced by 0.5% in HIV infection. The relative volume of the epithelium decreased by 2.4% (proliferative type). There were also significant changes in the structure of the glands and endometrium in secretory phase, as in the proliferative type. Thus, the average diameter of the glands decreased by 5%, the minimum volume of the glands by 5.01%, the maximum by 11.2%, the wall thickness by 1.5%, the relative volume of the epithelium by 9.5%, less in the group HIV-infected than in the comparison group. The thickness of the epithelium increased by 4.5% in the HIV-infected group compared with the comparison group.
Conclusion. The study evaluated features of endometrial restructuring in the presence of concomitant HIV infection in women.
References
Popova, L., Vasylyeva, L., Tkachenko, A., Polikarpova, H., Kokbas, U., Tuli, A, Kayrin, L., &Nakonechna, A. (2019). Menstrual cycle-related changes in blood serum testosterone and estradiol levels and their ratio stability in young healthy females. Inter colleges, 6(3), 155–161.
Lytvynenko, M., Bocharova, T., Zhelezniakova, N., Narbutova, T., & Gargin, V. (2017). Cervicaltransformation in alcohol abuse patients. Georgian medical news, (271), 12–17.
Shepherd, L., Borges, A., Ledergerber, B., Domingo, P., Castagna, A., Rockstroh, J., Knysz, B.,Tomazic, J., Karpov, I., Kirk, O., Lundgren, J., Mocroft, A., & EuroSIDA in EuroCOORD (2016).
Infection-related and -unrelated malignancies, HIV and the aging population. HIV medicine, 17(8), 590– 600. https://doi.org/10.1111/hiv.12359
Hyriavenko, N., Lyndin, M., Sikora, K., Piddubnyi, A., Karpenko, L., Kravtsova, O., Hyriavenko,D., Diachenko, O., Sikora, V., & Romaniuk, A. (2019). Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects. Journal of pathology and translational medicine, 53(4), 236–243. https://doi.org/10.4132/jptm.2019.03.21
Pelchen-Matthews, A., Ryom, L., Borges, A. H., Edwards, S., Duvivier, C., Stephan, C., Sambatakou, H., Maciejewska, K., Portu, J. J., Weber, J., Degen, O., Calmy, A., Reikvam, D. H., Jevtovic, D., Wiese, L., Smidt, J., Smiatacz, T., Hassoun, G., Kuznetsova, A., Clotet, B., … EuroSIDA study (2018). Aging and the evolution of comorbidities among HIV-positive individuals in a European cohort. AIDS (London, England), 32(16), 2405–2416. https://doi.org/10.1097/QAD.0000000000001967
Gargin, V., Radutny, R., Titova, G., Bibik, D., Kirichenko, A., & Bazhenov, O. (2020). Applicationof the computer vision system for evaluation of pathomorphological images. Paper presented at the 2020 IEEE 40th International Conference on Electronics and Nanotechnology, ELNANO 2020 – Proceedings, 469–473. doi:10.1109/ELNANO50318.2020.9088898
Wahlstrom, J. T., & Dobs, A. S. (2000). Acute and long-term effects of AIDS and injection druguse on gonadal function. Journal of acquired immune deficiency syndromes (1999), 25 Suppl 1, S27– S36. https://doi.org/10.1097/00042560-200010001-00005
Bull, L., Tittle, V., Rashid, T., & Nwokolo, N. (2018). HIV and the menopause: A review. Postreproductive health, 24(1), 19–25. https://doi.org/10.1177/2053369117748794
Lytvynenko, M., Shkolnikov, V., Bocharova, T., Sychova, L., & Gargin, V. (2017). Peculiaritiesof proliferative activity of cervical squamous cancer in hiv infection. Georgian medical news, (270), 10–15.
Zoufaly, A., Cozzi-Lepri, A., Reekie, J., Kirk, O., Lundgren, J., Reiss, P., Jevtovic, D., Machala, L.,Zangerle, R., Mocroft, A., Van Lunzen, J., & EuroSIDA in EuroCoord (2014). Immuno-virological discordance and the risk of non-AIDS and AIDS events in a large observational cohort of HIV-patients in Europe. PloS one, 9(1), e87160. https://doi.org/10.1371/journal.pone.0087160
Roan, N. R., & Jakobsen, M. R. (2016). Friend or Foe: Innate Sensing of HIV in the FemaleReproductive Tract. Current HIV/AIDS reports, 13(1), 53–63. https://doi.org/10.1007/s11904-016-0305-0.
Mor G. (2013). The female reproductive tract and HIV: biological, social and epidemiologicalaspects. American journal of reproductive immunology (New York, N.Y. : 1989), 69 Suppl 1, 1. https://doi.org/10.1111/aji.12082
Chumachenko, D., & Chumachenko, T. (2020). Intelligent agent-based simulation of HIV epidemicprocess. In: Lytvynenko, V., et al. (eds) Lecture Notes ... doi: 10.1007/978-3-030-26474-1_13
Kafka, J. K., Sheth, P. M., Nazli, A., Osborne, B. J., Kovacs, C., Kaul, R., & Kaushic, C. (2012). Endometrial epithelial cell response to semen from HIV-infected men during different stages of infection is distinct and can drive HIV-1-long terminal repeat. AIDS (London, England), 26(1), 27–36. https://doi.org/10.1097/QAD.0b013e32834e57b2
Reekie, J., Kowalska, J. D., Karpov, I., Rockstroh, J., Karlsson, A., Rakhmanova, A., Horban, A.,Kirk, O., Lundgren, J. D., Mocroft, A., & EuroSIDA in EuroCoord (2012). Regional differences in AIDS and non-AIDS related mortality in HIV-positive individuals across Europe and Argentina: the EuroSIDA study. PloS one, 7(7), e41673. https://doi.org/10.1371/journal.pone.0041673
Sanderson, P. A., Critchley, H. O., Williams, A. R., Arends, M. J., & Saunders, P. T. (2017). Newconcepts for an old problem: the diagnosis of endometrial hyperplasia. Human reproduction update, 23(2), 232–254. https://doi.org/10.1093/humupd/dmw042
Mahovlic, V., Ovanin-Rakic, A., Skopljanac-Macina, L., Barisic, A., Rajhvajn, S., Juric, D., Projic, I. S., Ilic-Forko, J., Babic, D., Skrablin-Kucic, S., & Bozikov, J. (2010). Digital morphometry of cytologic aspirate endometrial samples. Collegium antropologicum, 34(1), 45–51.
Silverberg S. G. (2007). The endometrium. Archives of pathology & laboratory medicine, 131(3),372–382.
Edi-Osagie, E. C., Seif, M. W., Aplin, J. D., Jones, C. J., Wilson, G., & Lieberman, B. A. (2004). Characterizing the endometrium in unexplained and tubal factor infertility: a multiparametric investigation. Fertility and sterility, 82(5), 1379–1389. https://doi.org/10.1016/j.fertnstert.2004.04.046
Sobczuk, K., & Sobczuk, A. (2017). New classification system of endometrial hyperplasia WHO2014 and its clinical implications. Przeglad menopauzalny = Menopause review, 16(3), 107–111. https://doi.org/10.5114/pm.2017.70589
Gu, Z., Zhu, P., Luo, H., Zhu, X., Zhang, G., & Wu, S. (1995). A morphometric study on theendometrial activity of women before and after one year with LNG-IUD in situ. Contraception, 52(1), 57–61. https://doi.org/10.1016/0010-7824(95)00125-t
Trimble, C. L., Method, M., Leitao, M., Lu, K., Ioffe, O., Hampton, M., Higgins, R., Zaino, R.,Mutter, G. L., & Society of Gynecologic Oncology Clinical Practice Committee (2012). Management of endometrial precancers. Obstetrics and gynecology, 120(5), 1160–1175. https://doi.org/10.1097/aog.0b013e31826bb121
Henyk, N., Hinchytska, L., Levytskyi, I., Neiko, O., & Gotsaniuk, R. (2017). The modern approachto the correction of menopausal disorders in women with physiological menopause and after ovariectomy. Galician Medical Journal, 24(2). https://doi.org/10.21802/gmj.2017.2.8
Hyriavenko, N., Lyndin, M., Sikora, K., Piddubnyi, A., Karpenko, L., Kravtsova, O., Hyriavenko, D.,Diachenko, O., Sikora, V., & Romaniuk, A. (2019). Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects. Journal of pathology and translational medicine, 53(4), 236–243. https://doi.org/10.4132/jptm.2019.03.21
Fernandes, A. T., da Rocha, N. P., Avvad, E., Grinsztejn, B. J., Russomano, F., Tristao, A.,Quintana, M., Perez, M. A., Conceicao-Silva, F., & Bonecini-Almeida, M. (2013). Balance of apoptotic and anti-apoptotic marker and perforin granule release in squamous intraepithelial lesions. HIV infection leads to a decrease in perforin degranulation. Experimental and molecular pathology, 95(2), 166–173. https://doi.org/10.1016/j.yexmp.2013.06.006
Litta, P., Agnello, A., & Azzena, A. (1992). HPV genital infections and contraception. Clinical andexperimental obstetrics & gynecology, 19(2), 136–138.
Green A. (2017). The HIV response in Ukraine: at a crossroads. Lancet (London, England),390(10092), 347–348. https://doi.org/10.1016/S0140-6736(17)31915-3
Lu, B., Yu, M., Shi, H., & Chen, Q. (2019). Atypical polypoid adenomyoma of the uterus: Areappraisal of the clinicopathological and immunohistochemical features. Pathology, research and practice, 215(4), 766–771. https://doi.org/10.1016/j.prp.2019.01.016
Zhou, X., Xu, Y., Yin, D., Zhao, F., Hao, Z., Zhong, Y., Zhang, J., Zhang, B., & Yin, X. (2020). Type 2 diabetes mellitus facilitates endometrial hyperplasia progression by activating the proliferative function of mucin O-glycosylating enzyme GALNT2. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 131, 110764. https://doi.org/10.1016/j.biopha.2020.110764
Sivridis, E., & Giatromanolaki, A. (2011). The pathogenesis of endometrial carcinomas atmenopause: facts and figures. Journal of clinical pathology, 64(7), 553–560. https://doi.org/10.1136/jcp.2010.085951
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