THE IMPACT OF SMOKING ON THE MORPHOFUNCTIONAL STATE OF PERIODONTAL TISSUES OF YOUNG ORGANISM
PDF

Keywords

smoking, oral mucosa, ischemia, microcirculatory bed, periodontitis, histology, experiment

Abstract

Background. The interrelation of disorders in periodontal tissues with metabolic changes caused, in particular, by a violation of microcirculation, observed namely in smoking but the fact that the effect of smoking on the condition of periodontal tissues at a young age has been studied less than other risk factors deserves special attention. The aim of our study was to experimentally assess the effect of smoking on the morphofunctional state of periodontal tissues in young animals. 

Materials and methods. Simulation of smoking has been performed with ten-week-old WAG rats using the Boyarchuck chamber. Morphometric studies were performed in the gingival zone which was chosen for morphological interpretation of volumes of specific vascular density in microcirculatory bed, specific density of connective tissue in lamina propria and specific area of tissue with ischemia. The obtained digital data were processed by the methods of variation statistics. 

Results. Simulation of smoking for four weeks in experimental animals leads to pathological changes in the morphofunctional state of the periodontium with reducing vascular density from 19,44±1,97% to 11,03±1,38 %, increasing area of connective tissue from 18,33±2,71% to 26,49±1,24%, spreading area of tissue with ischemia from 1,14±0,70% to 6,35±1,67%. 

Conclusions. Morphofunctional changes in the periodontium with damage to the structure of the epithelial membrane and changes in its permeability, microcirculatory disorders, sclerotic changes are a manifestation of the initial inflammatory and dystrophic processes that can lead to persistent chronic pathology.

https://doi.org/10.35339/ic.8.1.47-51
PDF

References

Bashirian, S., Seyedzadeh-Sabounchi, S., Shirahmadi, S., Karimi-Shahanjarini, A., Soltanian, A. R., & Vahdatinia, F. (2021). Predictors of oral health promotion behaviors among elementary school children: Examination of an extended social cognitive theory. International journal of paediatric dentistry, 31(2), 191–203. https://doi.org/10.1111/ipd.12659

Hasiuk, P. A., Malko, N. V., Vorobets, A. B., Ivanchyshyn, V. V., Rosolovska, S. O., Korniienko, M. M., & Bedenyuk, O. A. (2020). The intensity of chronic catarrhal gingivitis in children depending on the age. Wiadomosci lekarskie (Warsaw, Poland : 1960), 73(5), 846–849.

Xiao, J., Fiscella, K. A., & Gill, S. R. (2020). Oral microbiome: possible harbinger for children's health. International journal of oral science, 12(1), 12. https://doi.org/10.1038/s41368-020-0082-x

Shcherba, V., Havrylenko, Y., Krynytska, I., Marushchak, M., & Korda, M. (2020). A comparative study of oral microbiocenosis structure in experimental comorbidity-free periodontitis and in periodontitis combined with thyroid dysfunction. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 48(283), 32–38.

Beketova, G., Kuznetsova, L., Grynevych, O., Broun, T., Momotiuk, L., Motuzka, O., & Yashchenko, L. (2021). Analysis of the clinical trial results of the flavonoid effects on some cellular immunity indicators in children and adults. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 49(289), 44–53.

Nazaryan, R., Tkachenko, M., Kovalenko, N., Babai, O., Karnaukh, O., & Gargin, V. (2019). Analysis of local immunity indicators of the oral cavity and degree of gingivitis depending on mutation of CFTR gene in children with cystic fibrosis. Georgian Medical News, (296), 27-31.

Bokor-Bratić M. (2002). Uticaj pusenja na stanje parodoncijuma [Effects of smoking on the periodontium]. Medicinski pregled, 55(5-6), 229–232. https://doi.org/10.2298/mpns0206229b

Nazaryan, R., Kryvenko, L., Zakut, Y., Karnaukh, O., & Gargin, V. (2020). Application of estimated oral health indices in adolescents with tobacco addiction. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 48(287), 327–330.

Popova, T. M., Gorbach, T. V., Tsygankova, T. I., & Shushliapina, N. O. (2018). Influence of cigarette smoking duration on endothelial cell function. [Uticaj duαine pušenja cigareta na funkciju endotelijalnih ćelija] Medicinski Casopis, 52(3), 98-104. doi:10.5937/mckg52-17769

Mackenbach, J. P., Damhuis, R. A., & Been, J. V. (2017). De gezondheidseffecten van roken [The effects of smoking on health: growth of knowledge reveals even grimmer picture]. Nederlands tijdschrift voor geneeskunde, 160, D869.

Kim, Y. G., Lee, S. M., Bae, S., Park, T., Kim, H., Jang, Y., Moon, K., Kim, H., Lee, K., Park, J., Byun, J. S., & Kim, D. Y. (2021). Effect of Aging on Homeostasis in the Soft Tissue of the Periodontium: A Narrative Review. Journal of personalized medicine, 11(1), 58. https://doi.org/10.3390/jpm11010058

Karsiyaka Hendek, M., Erkmen Almaz, M., Olgun, E., & Kisa, U. (2019). Salivary LL-37 and periodontal health in children exposed to passive smoking. International journal of paediatric dentistry, 29(3), 369–374. https://doi.org/10.1111/ipd.12459

Curtis, M. A., Diaz, P. I., & Van Dyke, T. E. (2020). The role of the microbiota in periodontal disease. Periodontology 2000, 83(1), 14–25. https://doi.org/10.1111/prd.12296

Abusleme, L., Hoare, A., Hong, B. Y., & Diaz, P. I. (2021). Microbial signatures of health, gingivitis, and periodontitis. Periodontology 2000, 10.1111/prd.12362. Advance online publication. https://doi.org/10.1111/prd.12362

Gargin, V., Radutny, R., Titova, G., Bibik, D., Kirichenko, A., & Bazhenov, O. (2020). Application of the computer vision system for evaluation of pathomorphological images. Paper presented at the 2020 IEEE 40th International Conference on Electronics and Nanotechnology, ELNANO 2020 - Proceedings, 469-473. doi:10.1109/ELNANO50318.2020.9088898

Fesenko, D., Glazunov, O., Nakonechna, O., Nazaryan, R., & Gargin, V. (2019). Consequences of microsequences of microcirculatory distrurbances of oral mucosa in modeling of rheumatoid arthritis. Georgian Medical News, (295), 137-140.

Denga, O., Pyndus, T., Gargin, V., & Schneider, S. (2017). Influence of metabolic syndrome on condition of microcirculatory bed of oral cavity. Georgian medical news, (273), 99–104.

Kulik, T., & Kozieł, S. (2020). Social position in a peer group of school-aged boys and selected biological parameters. Anthropological Review, 83(4), 439-447. doi:10.2478/anre-2020-0032

Chmielewski, P. P. (2020). The dynamic nature of ageing: Novel findings, therapeutic avenues and medical interventions. Anthropological Review, 83(1), 75-92. doi:10.2478/anre-2020-0001

Olczak-Kowalczyk, D., Tomczyk, J., Gozdowski, D., & Kaczmarek, U. (2020). Cigarette smoking as an oral health risk behavior in adolescents: A cross-sectional study among polish youths. Anthropological Review, 83(1), 53-64. doi:10.2478/anre-2020-0007

Cullen, K. A., Liu, S. T., Bernat, J. K., Slavit, W. I., Tynan, M. A., King, B. A., & Neff, L. J. (2019). Flavored Tobacco Product Use Among Middle and High School Students - United States, 2014-2018. MMWR. Morbidity and mortality weekly report, 68(39), 839–844. https://doi.org/10.15585/mmwr.mm6839a2

Stryjewska, K., Pytko-Polonczyk, J., Sagbraaten, S., Sagbraaten, S., & Stryjewski, P. J. (2020). The oral health of patients with acute coronary syndrome confirmed by means of coronary angiography. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 48(283), 23–26.

Pawlowicz, A., Tymczyna-Borowicz, B., & Ptasiewicz, M. (2020). The state of the oral health in patients with type 2 diabetes. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 48(283), 27–31.

Staples, R. J., Ivanovski, S., & Vaquette, C. (2020). Fibre guiding scaffolds for periodontal tissue engineering. Journal of periodontal research, 55(3), 331–341. https://doi.org/10.1111/jre.12729

Nechyporenko, A. S., Reshetnik, V. M., Alekseeva, V. V., Yurevych, N. O., Nazaryan, R. S., & Gargin, V. V. (2020). Implementation and analysis of uncertainty of measurement results for lower walls of maxillary and frontal sinuses. Paper presented at the 2020 IEEE 40th International Conference on Electronics and Nanotechnology, ELNANO 2020 - Proceedings, 460-463. doi:10.1109/ELNANO50318.2020.9088916

Avetikov, D., Loza, K., Starchenko, I., Loza, E., & Marushchak, M. (2015). Experimental-morphological substantiation of expediency to use the skin glue "Dermabond" for postoperative wound closure. Georgian medical news, (244-245), 90–93.

Kovach, I., Kravchenko, L., Khotimska, Y., Nazaryan, R., & Gargin, V. (2017). Influence of ozone therapy on oral tissue in modeling of chronic recurrent aphthous stomatitis. Georgian medical news, (264), 115–119.

Copyright for articles published in the journal is regulated by the License Agreement for the use of a scientific article in the journal, which is concluded between the author of the article (Licensor) and Kharkov National Medical University (Licensee, publisher of the journal "Inter Collegas"). The licensor grants to the Licensee a non-exclusive non-exclusive license for the use of the article (a license that does not exclude the use of the article by the Licensor and the issuance of licenses to others for use of this article) on the terms and for the period specified in the contract. The licensor (the author of the article) grants the Licensee the right to reproduce the article (publication in the journal "Inter Collegas", publication, duplication, duplication or other reproduction of the article without limiting the circulation of copies, each copy of the article must contain the name of the Licensor; Of general information, including the publication of the article in full or in part on the Internet on the journal page, the right to use the metadata of the article (titles, full names of authors, annotations, bibliography eskih materials) through the dissemination and communication to the public, processing and systematization, as well as inclusion in various databases and in-formational system).

The licensor grants the licensee the right to transfer, store and process his personal data (full name, scientific degree, academic title, place of work and position, contact information of the authors) with the purpose of including them in the database in accordance with the Law of Ukraine No. 2297 - VI "on protection of personal data" from 01.06.2010.

Personal data and metadata of the article are provided for their storage and processing in various databases and information systems, including them in analytical and statistical reporting, creating sound relationships between the objects of works of science, literature and art with personal data, etc. on unlimited territory. The licensee has the right to transfer the specified data for processing and storage to third parties provided that such a fact is notified with the provision of information about the third party (name and address) to the Licensor.