CALCIUM-PHOSPHORUS RELATIONSHIPS IN THE COMBINED COURSE OF STABLE ISCHEMIC HEART DISEASE IN PATIENTS WITH OBESITY
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Keywords

stable coronary heart disease, obesity, mineral metabolism, osteoporosis.

Abstract

The purpose of the study was to optimize the diagnosis and prediction of the development of structural and functional disorders of bone tissue in patients with SCHD and obesity. Thus, lipid profile analysis showed a clinically significant increase in total cholesterol and triglycerides in patients with SCHD. Serum bone mineral status did not exceed normal values, but serum total calcium levels were significantly higher in patients with SCHD and obesity compared to other groups. The indicators of calcium-phosphorus metabolism in the daily urine of patients with SCHD were significantly higher. When conducting densitometric studies in patients with SCHD with normal weight, osteopenic conditions were diagnosed more often than in patients with overweight and obesity. That is, the comorbid course of SCHD and obesity is a high risk of osteodeficiency, which is confirmed by early changes in calcium-phosphorus metabolism.   

https://doi.org/10.35339/ic.8.2.106-110
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References

VOZ centr SMI (2015) [WHO Media Center (2015)]. Serdechno-sosudistye zabolevanija. Informacionnyj bjulleten' No. 317 [Cardiovascular Disease. Fact Sheet No. 317]. Retrieved from: http://www.who.int/mediacentre/factsheets/fs317/ru [Russian].

Pasiyeshvili, L.M., Ivanova, K.V. (2018). Role of calcium-phosphorus metabolism in the pathogenesis of stable coronary artery disease in patients with obesity. Bulletin of problems biology and medicine», 143 (1)-2, 175-179. DOI: 10.29254/2077-4214-2018-1-2-143-175-179. [Ukrainian].

Guénard, F. [Guenard, F.], Houde, A., Bouchard, L. (2012) Association of LIPA Gene Polymorphisms with Obesity-Related Metabolic Complications Among Severely Obese Patients. Obesity, 20(10), 2075-82. DOI: 10.1038/oby.2012.52.

Zhang, Y., Wang, S. (2012). Differences in development and the prevalence of obesity among children and adolescents in different socioeconomic status districts in Shandong. Atlas of Human Biology, China, 39(4), 290-296. DOI: 10.3109/03014460.2012.690888. PMID: 22670855.

Ivanova, K.V., Pasieshvili, L.M. (2018). Metabolic significance of variations in the level of fibroblast growth factor 21 in the combination of coronary heart disease and obesity. Ukrainian Journal of Medicine, Biology and Sports, 4(3)-13, 151-155. DOI: 10.26693/jmbs03.04.110. [Ukrainian].

VOZ centr SMI (2015) [WHO Media Center (2015)]. Serdechno-sosudistye zabolevanija. Informacionnyj bjulleten' No. 317 [Cardiovascular Disease. Fact Sheet No. 317]. Retrieved from: http://www.who.int/mediacentre/factsheets/fs317/ru [Russian].

Lee, S.N., Cho, J.Y., Eun, Y.M. (2016). Associations between osteoporosis and coronary artery disease in postmenopausal women. Climacteric, 19(5), 458–462. DOI: 10.1080/13697137.2016.1200550. PMID: 27397609.

Lewiecki, E.M. (2010). Fracture risk assessment in clinical practice: T-scores, FRAX, and beyond. Clinical Reviews in Bone and Mineral Metabolism, 8, 101–112. DOI: 10.1007/s12018-009-9054-6.

Barna, O.M., Jarema, N.І. [Yarema, N.І.], Bazilevich, A.Ja. [Bazilevich, A.Ya.] (2009). Patofіzіologіchnі ta klіnіchnі paralelі SІHS ta osteoporozu [Pathophysiological and clinical parallels of SIHS and osteoporosis]. Lіki Ukraїni [Medicines of Ukraine], 3(129), 43–46.

Gavisova, A.A., Tverdikova, M.A., Jakushevskaja, O.V. [Yakushevskaya, O.V.] (2012) Osteoporoz: sovremennyj vzgljad na problem [Osteoporosis: a modern perspective on the problem]. Russkij medicinskij zhurnal [Russian medical journal], 20(21), 1110–1116.

Vertkin, A.L., Naumov, A.V., Goruleva, E.I. (2012). Osteoporoz kak komponent serdechno-sosudistogo kontinuuma [Osteoporosis as a component of the cardiovascular continuum]. Lechashhij vrach [Attending physician], 2, 18–26. Retrieved from: http://www.lvrach.ru/2012/02/15435341/

Karpova, I.S. (2012). Vzaimosvjaz' kal'cinoza arterij i klapannogo apparata serdca i osteoporoza [The relationship between arterial and valvular calcification and osteoporosis]. Kardiologija v Belarusi [Cardiology in Belarus], 1, 98–104.

Karpova I.S., Manak, N.A., Koshlataja, O.V. (2012). Vzaimosvjaz' mineral'noj plotnosti kostej, lipidnogo obmena i endotelial'noj funkcii u zhenshhin s IBS i postmenopauzal'nym osteoporozom [The relationship between bone mineral density, lipid metabolism and endothelial function in women with coronary artery disease and postmenopausal osteoporosis]. Bol'. Sustavy. Pozvonochnik [Pain. Joints. Spine], 4(08). Retrieved from: http://www.mif-ua.com/archive/article/34605

Watts, N.B., Adler, R.A., Bilezikian, J.P., Drake, M.T., Eastell, R., Orwoll E.S. (2012). Osteoporosis in men: an endocrine society clinical practice guideline. The Journal of clinical Endocrinology and Metabolism, 97(6), 1802–22. DOI: 10.1210/jc.2011-3045. PMID: 22675062.

Рolonskaja, Ja.V. [Рolonskaya, Ya.V.], Kashtanova, E.V., Murashev, I.S. (2015). Vzamosvjaz' osnovnyh pokazatelej kal'cievogo i lipidnogo obmena s aterosklerozom koronarnyh arterij [Relationship of the main indicators of calcium and lipid metabolism with atherosclerosis of the coronary arteries]. Ateroskleroz i dislipidemii [Atherosclerosis and dyslipidemia], 1, 24–29.

Montalcini, T., Gorgone, G, Pujia, A. (2012). Serum calcium level is related to both intima-media thickness and carotid atherosclerosis a neglect risk factor in obese/overweight subject. Journal of Translational Medicine, 6(10), 11. DOI: 10.1186/1479-5876-10-114. PMID: 22672668.

Mee Kyoung Kim, Guilsun Kim, Eun Hee Jang (2010). Altered calcium homeostasis is correlated with the presence of metabolic syndrome and diabetes in middle-aged and elderly Korean subjects: The Chungju Metabolic Disease Cohort study. Atherosclerosis, 2, 674–681. DOI: 10.1016/j.atherosclerosis.2010.07.005. PMID: 20728085.

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