How to Cite
Abstract
THE INFLUENCE OF INTERLEUKIN-1Β, CARBOHYDRATE AND LIPID METABOLISM ON FORMATION OF MYOCARDIAL DIASTOLIC DYSFUNCTION IN TYPE 2 DIABETES MELLITUS
Zhuravlyova L.V., Sokolnikova N.V., Filonenko M.V.
Kharkiv National Medical University, Ukraine
Abstract. A total of 102 patients with type 2 diabetes and preserved left ventricular systolic function were examined in the endocrinology department of Kharkiv Regional Hospital. The following indexes were evaluated: body mass index, waist circumference, hip circumference, indexes of carbohydrate and lipid metabolism, and the concentration of IL-1β. All patients underwent echocardiography along with the determination of parameters of diastolic function. The results of statistical analysis showed that level of interleukin-1β, age, body mass index, waist to hip circumference ratio and the level of low-density lipoprotein take part in the formation of diastolic dysfunction.
Keywords: type 2 diabetes mellitus, body mass index, interleukin-1β, diastolic dysfunction.
ВПЛИВ ІНТЕРЛЕЙКІНУ-1Β, ВУГЛЕВОДНОГО І ЛІПІДНОГО ОБМІНУ НА ФОРМУВАННЯ СЕРЦЕВОЇ ДІАСТОЛІЧНОЇ ДИСФУНКЦІЇ ПРИ ЦУКРОВОМУ ДІАБЕТІ 2 ТИПУ
Журавльова Л.В., Сокольникова Н.В., Філоненко М.В.
Харьковский национальный медицинский университет, Украина
Резюме: В ендокринологічному відділенні КЗОЗ «ОКЛ – ЦЕМД та МК» обстежено 102 хворих на цукровий діабет 2 типу зі збереженою систолічною функцією лівого шлуночка. Було визначено індекс маси тіла, окружність талії, окружність стегон, показники вуглеводного, ліпідного обмінів, а також концентрація інтерлейкіну-1β. Всім хворим було проведено ехокардіографічне дослідження з визначенням показників діастолічної функції. В результаті статистичного аналізу встановлено, що у формуванні діастолічної дисфункції беруть участь рівень інтерлейкіну-1β, вік, індекс маси тіла, відношення окружності талії до окружності стегон, а також рівень холестерину ліпопротеїнів низької щільності.
Ключові слова: цукровий діабет 2 тип, індекс маси тіла, інтерлейкін-1β, діастолічна дисфункція.
ВЛИЯНИЕ ИНТЕРЛЕЙКИНА-1Β, УГЛЕВОДНОГО И ЛИПИДНОГО ОБМЕНА НА ФОРМИРОВАНИЕ СЕРДЕЧНОЙ ДИАСТОЛИЧЕСКОЙ ДИСФУНКЦИИ ПРИ САХАРНОМ ДИАБЕТЕ 2 ТИПА
Журавлева Л.В., Сокольникова Н.В., Филоненко М.В.
Харьковский национальный медицинский университет, Украина
Резюме: В эндокринологическом отделении КУОЗ «ОКБ – ЦЭМП и МК» обследованы 102 больных сахарным диабетом 2 типа с сохраненной систолической функцией левого желудочка. Были определены индекс массы тела, окружность талии, окружность бедер, показатели углеводного, липидного обменов, а также концентрация интерлейкина-1β. Всем больным было проведено эхокардиографическое исследование с определением значений диастолической функции. В результате статистического анализа установлено, что в формировании диастолической дисфункции у больных сахарным диабетом 2 типа участвуют уровень интерлейкина-1β, возраст, индекс массы тела, отношение окружности талии к окружности бедер, а также уровень холестерина липопротеинов низкой плотности.
Ключевые слова: сахарный диабет типа 2, индекс массы тела, интерлейкин-1β, диастолическая дисфункция.
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