Abstract
The treatment of non-specific chronic pleural empyema with bronchial fistulae remains one of the most relevant issues in thoracic surgery. The question about the treatment phasing of bronchial fistulae associated with chronic pleural empyema is yet to be answered. Is it reasonable to seal a bronchial fistula before or after the sanitation and obliteration of the residual pleural cavity? The choice of bronchial fistula sealing technique is also a relevant issue because, in spite of the multitude of techniques, there is still no single doctrine. The terms of traditional and minimally invasive techniques aimed at bronchial fistula sealing and pleural cavity obliteration are not defined, either. This article summarises the opinions of leading authors presented in the literature concerning the solution of this complex, life-threatening problem.
References
Cardillo G, Carleo F, Carbone L, Di Martino M, Salvadori L, Petrella L, Martelli M. Chronic postpneumonic pleural empyema: comparative merits of thoracoscopic versus open decortication. Eur J Cardiothorac Surg. 2009; 36(5): 914-8;
Chan DT, Sihoe AD, Chan S, Tsang DS, Fang B, Lee TW, Cheng LC. Surgical treatment for empyema thoracis: is video-assisted thoracic surgery ‘‘better’’ than thoracotomy? Ann Thorac Surg. 2007; 84(1): 225-31;
Perentes JY, Abdelnour-Berchtold E, Blatter J, Lovis A, et al. Vacuum-assisted closure device for the management of infected postpneumonectomy chest cavities. J Thorac Cardiovasc Surg. 2015; 149(3): 745-50;
Slobodenyuk I.F., Polezhaev A.A. Surgical treatment of bronchial fistulae after pneumonectomy. Thoracic and cardiovascular surgery. 2012; 1: 42-45;
Cerfolio RJ. The incidence, etiology and prevention of postresectional bronchopleural fistula. Semin Thorac Cardiovasc Surg. 2001; 13: 37;
Haraguchi S, Koizumi K, Hioki M, Hirata T, Hirai K, Mikami I et al. Analysis of risk factors for postpneumonectomy bronchopleural fistulas in patients with lung cancer. J Nippon Med Sch. 2006; 73: 314-9;
Light RW. Parapneumonic effusions and empyema. Proc Am Thorac Soc. 2006; 3(1): 75-80;
Groetzner J, Holzer M, Stockhausen D, Tchashin I, Altmayer M, Graba M, et al. Intrathoracic application of vacuum wound therapy following thoracic surgery. Thorac Cardiovasc Surg. 2009; 57: 417-20;
Lois M, Noppen M. Bronchopleural fistulas: an overview of the problem with special focus on endoscopic management. Chest. 2005; 128(6): 3955-3965.
Luh SP, Chou MC, Wang LS, Chen JY, Tsai TP. Video-assisted thoracoscopic surgery in the treatment of complicated parapneumonic effusions or empyemas: outcome of 234 patients. Chest. 2005; 127: 1427-1432;
Dickinson KJ, Taswell JB, Allen MS, Blackmon SH, Nichols FC 3rd, Shen R, Wigle DA, Cassivi SD. Unplanned Readmission After Lung Resection: Complete Follow-Up in a 1-Year Cohort With Identification of Associated Risk Factors. Ann Thorac Surg. 2017; 103(4): 1084-1091;
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015; 136(5): 359-86;
Vos, T. et al. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study. The Lancet. 2016; 388(10053): 1545-1602;
European Society of Thoracic Surgeons (2018). ESTS database annual report 2018. Retrieved from http://www.ests.org/private/database_reports.aspx
Sarkar P. Et al. Diagnosis and management bronchopleural fistula. The Indian Journal of Chest Diseases and Allied Sciences. 2010; 52;
Guilherme D. et al. Surgical approaches for bronchopleural fistula. Shanghai Chest. 2017; https://doi.org/10.21037/sch.2017.06.01
Li S, Fan J, Zhou J, Ren Y, Shen C, Che G. Residual disease at the bronchial stump is positively associated with the risk of bronchoplerual fistula in patients undergoing lung cancer surgery: a meta-analysis. Interact CardioVasc Thorac Surg. 2016; 22: 327-35;
Vagner E.A., Subbotin V.M., Makoveev V.I. et al. Endoscopic occlusion of the main bronchus stump in case of its leaks. Thoracic and cardiovascular surgery. 1990; 2: 46-48;
Li S, Fan J, Liu J, Zhou J, Ren Y, Shen C, Che G. Neoadjuvant therapy and risk of bronchopleural fistula after lung cancer surgery: a systematic meta-analysis of 14 912 patients. Jpn J Clin Oncol. 2016; 46(6): 534-46;
Burfeind WR Jr, D’Amico TA, Toloza EM, et al. Low morbidity and mortality for bronchoplastic procedures with and without induction therapy. Ann Thorac Surg. 2005; 80(2): 418-21;
Martin J, Ginsberg RJ, Abolhoda A, et al. Morbidity and mortality after neoadjuvant therapy for lung cancer: the risks of right pneumonectomy. Ann Thorac Surg. 2001; 72(4): 1149-54;
Ohta M, Sawabata N, Maeda H, et al. Efficacy and safety of tracheobronchoplasty after induction therapy for locally advanced lung cancer. J Thorac Cardiovasc Surg. 2003; 125(1): 96-100;
Sonobe M , Nakagawa M , Ichinose M , Ikegami N , Nagasawa M , Shindo T. Analysis of risk factors in bronchopleural fistula after pulmonary resection for primary lung cancer. Eur J Cardiothorac Surg. 2000; 18(5): 519-523;
Maio MD, Perrone F, Deschamps C, Rocco G. A meta-analysis of the impact of bronchial stump coverage on the risk of bronchopleural fistula after pneumonectomy. European journal of cardio-thoracic surgery. 2015; 48: 196-200;
Misthos P., Kakaris S., Sespas E., Athanassiadi K., Skottis I. Surgical management of late postpneumonectomy bronchopleural fistula: the transsternal, transpericardial route. Respiration. 2006; 73: 525-528;
Andreetti C., D Andrilli A., Ibrahim M., Ciccone AM., Maurizi G., Matia A. et al. Effective treatment of post-pneumonectomy bronchopleural fistula by conical fully covered self-expanded stent. Interac Cardiovasc Thorac Surg. 2012; 14(1): 420-423;
Giller D.B., Martel I.I., Bizhanov A.B., Enilenis I.I. et al. Tense pneumopericardium as a complication of transsternal transpericardial occlusion of the main bronchus stump. Surgery. 2018; 6: 16-20;
Darling G.E., Abdurahman A., Yi O.L., et al. Risk of a right pneumonectomy: role of bronchopleural fistula. Ann. Thorac. Surg. 2005. 79(2): 433-437;
Sirbu H., Busch T., Aleksis I. et al. Bronchopleural fistula in the surgery of non-small cell lung cancer: incidence, risk factors, and managment. Ann. Thorac. Cardiovasc. Surg. 2011. 7(6): 330-336;
Protsenko A.V., Lukyanov Yu.V. Factors influencing the incidence of bronchial fistula after pneumonectomy. Oncology. 2007; 4: 361-364;
Zahid I., Routledge T., Bille A., Scarci M. What is the best treatment of postpneumonectomy empyema? Interact Cardiovasc Thorac Surg. 2011; 12: 260-264; https://doi.org/10.1510/icvts.2010.254706;
Lee S.F., Lawrence D., Booth H. et al. Thoracic empyema: current opinions in medical and surgical management. Curr. Opin. Pulm. Med. 2010; 16(3): 194-200;
Tassi G.F., Marchetti G.P., Pinelli V., Chiari S. Practical management of pleural empyema. Monaldi Arch. Chest. Dis. 2010; 73(3): 124-129;
Shoykhet, Ya.N., Tseymakh E.A., Malchenko T.D. et al. Local treatment of acute pleural empyema and pyopneumothorax. Pulmonology. 2002; 3: 47 – 51;
Gostishchev, V.K. Infections in surgery: guidelines for doctors. M.: GEOTAR-Media. 2007; 768;
Vallieres E. Management of empyema after lung resections (pneumonectomy/lobectomy). Chest Surg Clin N Am. 2002; 12: 571-85;
Varker KA, Ng T. Management of empyema cavity with the vacuum-assisted closure device. Ann Thorac Surg. 2006; 81: 723-5;
Levin A.V., Tseymakh E.A., Samuylenkov A.M. et al. The use of valved bronchoblocker in post-resection empyema and residual cavities with bronchopleural fistulae. Problems of tuberculosis. 2007; 6: 46-49;
Dua J , Chessa M , Piazza L , et al . Initial experience with the new Amplatzer Duct Occluder II. J Invasive Cardiol. 2009; 21(8): 401-405;
Fruchter O., Kramer MR., Dagan T. et al. Endobronchial Closure of Bronchopleural Fistulae Using Amplatzer Devices. Chest. 2011; 139: 682-687; https://doi.org/10/1378/chest.10-1528;
Lin Yang, Jian Kong, Weihua Tao, et al. Tuberculosis Bronchopleural Fistula Treated with Atrial Septal Defect Occluder. Ann Thorac Surg. 2013; 96: 9-11; https://doi.org/10.1016/j.athoracsur.2012.12.062;
Mahajan AK, et al. Intrabronchial valves: a case series describing a minimally invasive approach to bronchopleural fistulas in medical intensive care unit patients. J Bronchology Interv Pulmonol. 2012; 19: 137-141;
Nagahiro I, Aoe M, Sano Y, et al. Bronchopleural fistula after lobectomy for lung cancer. Asian Cardiovasc Thorac Ann. 2007; 15: 45-48;
Takanami I. Closure of a bronchopleural fistula using a fibrin-glue coated collagen patch. Interact Cardiovasc Thorac Surg. 2003; 2: 387-388;
Ovchinnikov A.A., Shutulko A.M., Yasnogorodskiy O.O., Motus I.Ya. Endoscopic thoracic surgery. Guidelines for doctors. M.: Medicine. 2006;
Passera E., Guanella G., Meroni A. et al. Amplatzer device with vacuum – assisted closure therapy to treat a thoracic empyema with bronchopleural fistula. Ann. Thorac. Surg. 2011; 92: e23-e25; https://doi.org/10.1016/j.athoracsur.2011.03.047;
Bogush L.K., Travin A.A., Semenenkov Yu.L. Surgeries on main bronchi through the pericardial cavity. M.: Medicine. 1972;
Tedde ML., Scordamaglio PR., Minamoto H. et al. Endobronchial closure of total bronchopleural fistula with occlutech figulla ASD N Device. Ann. Thorac. Surg. 2009; 88: e25-e26; https://doi.org/10.1016/j.athoracsur.2011.03.047;
Fruchter O., Bruckheimer E., Raviv Y. et al. Endobronchial closure of bronchopleural fistulas with Amplatzer vascular plug. Eur. J. Cardiothorac. Surg. 2012; 41(1): 46-49;
Harada A., Nakamura Y., Fukumori K. et al. Negative pressure wound therapy was useful in treating empyema with bronhopleural fistula. Kyobu Geka. 2010; 63(12): 1039-1043;
Planta M., Vargas P., Niedmann J., Lyon S. Closure of bronchopleural fistula with Angio-Seal. Cardiovasc. Intervent. Radiol. 2011; 34(2): 236-239;
Schweigert M., Kraus D., Ficker J.H., Stein H.J. Closure of persisting air leaks in patients with severe pleural empyema – use of endoscopic one-way endobronchial valve. Eur. J. Cardiothorac. Surg. 2011; 39(3): 401-403;
Tedde M.I., Scordamaglio P.R., Minamoto H. Endobronchial closure of total bronchopleural fistula with Occlutech Figulla ASD N device. Ann. Thorac. Surg. 2009; 88(3): 25-26;
Piershyn Ye.S. Pat.58315 А (UA), МПК А61М 25/00. The method of bronchial occlusion. M. Gorky Donetsk State Medical University – 2002119382. Application 27.09.2007; published 10.12.2007, Bull. No. 20; 3;
Parthasarathi B. Bronchosopic endobronchial sealing: a novel technique of treating bronchopleural fistula (BPF). Chest. 2003; 124: 147;
Krasilnikov D.M., Khasanov R.N., Bondarev A.V. et al. The use of temporary bronchial obturation in the prevention and treatment of complications after lung and pleura surgeries. Kazan medical journal. 2001. 82(4): 253-255;
Brichon PY, Poquet C, Arvieux C, Pison C. Successful treatment of a lifethreatening air leakage, complicating severe abdominal sepsis, with a one-way endobronchial valve. Interact Cardiovasc Thorac Surg. 2012; 15: 779-780;
Seleznev, Yu.P. Comprehensive treatment of suppurative diseases of lungs and closed pleuropulmonary cavities: abstract. diss. ... doct. med. sc. Voronezh. 2000; 35;
Matveev, V.Yu. Improvement of the temporary bronchial obturation method in the comprehensive treatment of pleural empyema: abstract. diss. ... cand. med. sc. Kazan. 2005; 33;
Zolotarev D.V., Degtarova E.V. Thoracoscopic methods in the comprehensive treatment of non-specific pleural empyema and purulent and destructive lung diseases. Surgery. N.I. Pirogov Journal. 2014; 10: 15-20;
Giddings O, Kuhn J, Akulian J. Endobronchial valve placement for the treatment of bronchopleural fistula: a review of the current literature. Curr Opin Pulm Med. 2014; 20(4): 347-351;
Regnard JF, Alifano M, Puyo P, et al. Open window thoracostomy followed by intrathoracic flap transposition in the treatment of empyema complicating pulmonary resection. J Thorac Cardiovasc Surg. 2000; 120(2): 270-275;
Seify H, Mansour K, Miller J, Douglas T, Burke R, Losken A, Culbertson J, Jones G, Nahai F, Hester TR. Single-stage muscle flap reconstruction of the postpneumonectomy empyema space: The Emory experience. Plast Reconstr Surg. 2007; 120(7): 1886-1891;
Ng CS, Wan S, Lee TW, Wan IY, Arifi AA, Yim AP. Post-pneumonectomy empyema: current management strategies. ANZ J Surg. 2005; 75(7): 597-602;
Takanari K, Kamei Y, et al. Management of postpneumonectomy empyema using free flap and pedicled flap. Ann Thorac Surg. 2010; 89(1): 321-323;
Walsh MD, Bruno AD, Onaitis MW, et al. The role of intrathoracic free flaps for chronic empyema. Ann Thorac Surg. 2011; 91(3): 865-868;
Tsai FC, Chen HC, Chen SH, et al. Free deepithelialized anterolateral thigh myocutaneous flaps for chronic intractable empyema with bronchopleural fistula. Ann Thorac Surg. 2002; 74: 1038-1042;
Molnar JA, Pennington DG. Management of postpneumonectomy bronchopleuralcutaneous fistula with a single free flap. Ann Plast Surg. 2002; 48: 88-91;
Jiang L, Jiang GN, He WX, Fan J, Zhou YM, Gao W, Ding JA. Free rectus abdominis musculocutaneous flap for chronic postoperative empyema. Ann Thorac Surg. 2008; № 85(6): 2147-2149;
Chan DT, Sihoe AD, Chan S, Tsang DS, Fang B, Lee TW, Cheng LC. Surgical treatment for empyema thoracis: is video-assisted thoracic surgery ‘‘better’’ than thoracotomy? Ann Thorac Surg. 2007; 84(1): 225-231;
Massera F, Robustellini M, Della Pona C, Rossi G, Rizzi A, Rocco G. Open window thoracostomy for pleural empyema complicating partial lung resection. Ann Thorac Surg. 2009; 87: 869-873;
Zaheer S, Allen MS, Cassivi SD, et al. Postpneumonectomy empyema: results after the Clagett procedure. Ann Thorac Surg. 2006; 82(1): 279-286;
Topcuoglu MS et al. Transsternal transpericardial approach for the repair of bronchopleural fistula with empyema. Ann Thorac Surg. 2000; 69: 394-397;
Taghavi S, Marta GM, Lang G, et al. Bronchial stump coverage with a pedicled pericardial flap: an effective method for prevention of postpneumonectomy bronchopleural fistula. Ann Thorac Surg. 2005; 79(1): 284-288;
Gursov S., Yapucu M.U., Ucvet A. et al. Fibrin glue administration to support bronchial stump line. Asian Cardiovasc. Thorac. Ann. 2008; 16(6): 4500-453;
Uçvet A, Gursoy S, Sirzai S, et al. Bronchial closure methods and risks for bronchopleural fistula in pulmonary resections: how a surgeon may choose the optimum method? Interact CardioVasc Thorac Surg. 2011; 12: 558–62;
Zakkar M, et al. No evidence that manual closure of the bronchial stump has a lower failure rate than mechanical stapler closure following anatomical lung resection. Interact Cardiovasc Thorac Surg. 2014; 18: 488-93;
Beltrami V, Angelici A, et al. Transsternal approach to closure of bronchopleural fistulas after pneumonectomy. Lung Cancer. 2000; 1: 43-47;
Chichevatov D, et al. Omentoplasty in treatment of early bronchopleural fistulas after pneumonectomy. Asian Cardiovasc Thorac Ann. 2005; 3: 211-216;
Panagopoulos ND, Apostolakis E, Koletsis E, Prokakis C, Hountis P, Sakellaropoulos G et al. Low incidence of bronchopleural fistula after pneumonectomy for lung cancer. Interact CardioVasc Thorac Surg. 2009; 9: 571-5;
Tolstolutskiy A.Yu. The influence of physicochemical quality indicators of antiseptic solutions on micro- and macrostructure of pus and pharmacological optimization of the surgical treatment of tubercular pleural empyema: abstrat. diss. doct. med. sc: 14.01.03. Chelyabinsk. 2010; 24;
Abdulkhakim Al Kamali. Purulent and gangrenous lung abscesses with pleural complications and their comprehensive treatment: abstract of diss. Doct. Med. Sc.: spec.14.01.03. – surgery. Vinnytsia. 2010; 21;
Pechetov A.A., Gritsyuta A.Yu., Yesakov Yu.S., Lednev A.N. Transsternal occlusion of the main bronchus stump with bronchopleural fistula and non-specific pleural empyema. Surgery. N.I. Pirogov journal. 2019; 7: 5-9; https://doi.org/10.17116/hirurgia20190715;
Boyko V.V., Smolyanik K.N., Kozin Yu.I., Minukhin D.V., Tokarev A.V. Treatment of post-resection pleural empyema complicated by bronchopleural fistula. Kharkiv surgical school. 2015; 1(70): 49-53;
Kanavel AB. Plastic procedures for obliteration of cavities with non-collapsible walls. Chicago Surgical Society Meeting. 1920;
Robinson S. The treatment of chronic non-tuberculous empyema. Surg Gynecol Obstet. 1916; 22: 557;
Arnold PG, Pairolero PC. Chest wall reconstruction: Experience with 100 consecutive patients. Ann. Surg. 1984; 199: 725;
Miller, J.I, Mansour, K. A, Nahai, F, et al. Single stage complete muscle flap closure of the postpneumonectomy space: A new method and possible solution to a disturbing complication. Ann Thorac Surg. 1984; 38: 227;
Hallock G. Intrathoracic application of the transverse rectus abdominis musculocutaneous flap. Ann Plast Surg. 1992; 29: 357;
Iverson L, Young J, Ecker R, et al. Closure of bronchopleural fistulas by an omental pedicle flap. Am J Surg. 1986; 152: 40;
Jurkiewicz MJ, Arnold PG. The omentum: An account of its use in the reconstruction of the chest wall. Ann Surg. 1977; 185: 548;
Tseymakh, Ye.A., Levin A.V., Zimonin P.E., Samuylenkov A.M. Pleural empyema. Surgical treatment techniques. Part III. Tuberculosis and lung diseases. 2010; 2: 5 -12;
Babu AN, Mitchell JD. Technique for muscle flap harvest for intrathoracic use. Operat Tech Thorac Cardiovasc Surg. 2010; 15: 41-52;
Krassas A, Grima R, Bagan P, et al. Current indications and results for thoracoplasty and intrathoracic muscle transposition. Eur J Cardiothorac Surg. 2010; 37: 1215-1220;
Stefani A, Jouni R, Alifano M, Bobbio A, Strano S, Magdeleinat P, Regnard JF. Thoracoplasty in the current practice of thoracic surgery: a single-institution 10-year experience. Ann Thorac Surg. 2011; 91(1): 263-268;
Botianu PV, Botianu AM, Dobrica AC, et al. Intrathoracic transposition of the serratus anterior muscle flap – personal experience with 65 consecutive patients. Eur J Cardiothorac Surg. 2010; 38: 669-673;
Deslauriers J, Grégoire J. Thoracoplasty. Pearson’s thoracic and esophageal surgery, 3rd ed. Philadelphia: Churchill Livingstone Elsevier. 2008; 1159-1169;
Fournier I, Krueger T, Wang Y, Meyer A, Ris HB, Gonzalez M. Tailored thoracomyoplasty as a valid treatment option for chronic postlobectomy empyema. Ann Thorac Surg. 2012; 94(2): 387-393;
Okada M, Tsubota N, Yoshimura M, et al. Surgical treatment for chronic pleural empyema. Surg Today. 2000; 30(6): 506-510;
"Inter Collegas" is an open access journal: all articles are published in open access without an embargo period, under the terms of the CC BY-NC-SA (Creative Commons Attribution ‒ Noncommercial ‒ Share Alike) license; the content is available to all readers without registration from the moment of its publication. Electronic copies of the archive of journals are placed in the repositories of the KhNMU and V.I. Vernadsky National Library of Ukraine.
Copyright Agreement
1. This Agreement on the transfer of rights to use the work from the Co-authors to the publisher (hereinafter the Agreement) is concluded between all the Co-authors of the work, represented by the Corresponding Author, and Kharkiv National Medical University (hereinafter the University), represented by an authorized representative of the Editorial Board of scientific journals (hereinafter the Editorial Board).
2. This Agreement is an accession agreement within the meaning of clause 1 of Article 634 of the Civil Code of Ukraine: that is, a contract, "the terms of which are established by one of the parties in forms or other standard forms, which can be concluded only by joining the other party to the proposed contract as a whole. The other party cannot offer its terms of the contract." The party that established the terms of this contract is the University.
3. If there is more than one author, the authors choose the Corresponding Author, who communicates with the Editorial Board on his own behalf and on behalf of all Co-authors regarding the publication of a written work of a scientific nature (article or review, hereinafter referred to as the Work).
4. The contract begins from the moment of submission of the manuscript of the Work by the Corresponding Author to the Editorial Board, which confirms the following:
4.1. all Co-authors of the Work are familiar with and agree with its content, at all stages of reviewing and editing the manuscript and the existence of the published Work;
4.2. all Co-authors of the Work are familiar with and agree to the terms of this Agreement.
5. The published Work is in electronic form in public access on the websites of the University and any websites and electronic databases in which the Work is posted by the University and is available to readers under the terms of the "Creative Commons" license (Attribution NonCommercial Sharealike 4.0 International)" or more free licenses "Creative Commons 4.0".
6. The Corresponding Author transfers, and the University receives, the non-exclusive property right to use the Work by placing the latter on the University's websites for the entire term of copyright. The University participates in the creation of the final version of the Work by reviewing and editing the manuscript of the article or review provided to the Editorial Board by the Corresponding Author, translating the Work into any languages. For the participation of the University in the finalization of the Work, the Co-authors agree to pay the invoice issued to them by the University, if such payment is provided by the University. The size and procedure of such payment are not the subject of this contract.
7. The University has the right to reproduce the Work or its parts in electronic and printed forms, to make copies, permanent archival storage of the Work, distribution of the Work on the Internet, repositories, scientometric databases, commercial networks, including for monetary compensation from third parties.
8. The co-authors guarantee that the manuscript of the Work does not use works whose copyright belongs to third parties.
9. The authors of the Work guarantee that at the time of submission of the manuscript of the Work to the Editorial Board, the property rights to the Work belong only to them, neither in whole nor in part have they been transferred to anyone (not alienated), they are not the subject of a lien, litigation or claims by third parties.
10. The Work may not be posted on the University's website if it violates a person's right to the privacy of his personal and family life, harms public order and health.
11. The work may be withdrawn by the Editorial Board from the University websites, libraries and electronic databases where it was placed by the Editorial Board, in cases of detection of violations of the ethics of the authors and researchers, without any compensation for the losses of the Co-authors. At the time of submission of the manuscript to the Editorial Board and all stages of its editing and review, the manuscript must not have already been published or submitted to other editorial offices.
12. The right transferred under this Agreement extends to the territory of Ukraine and foreign countries.
13. The rights of Co-authors include the requirement to indicate their names on all copies of the Work or during any public use or public mention of the Work; the requirement to preserve the integrity of the Work; legal opposition to any distortion or other encroachment on the Work, which may harm the honor and reputation of the Co-authors.
14. Co-authors have the right to control their personal non-property rights by familiarizing themselves with the text (content) and form of the Work before its publication on the University's website, when transferring it to a printing company for reproduction or when using the Work in other ways.
15. The Co-authors, in addition to the property rights not transferred under this Agreement and taking into account the non-exclusive nature of the rights transferred under this Agreement, retain the property rights to finalize the Work and to use certain parts of the Work in other works created by the Co-authors.
16. The Co-authors are obliged to notify the Editorial Board of all errors in the Work, discovered by them independently after the publication of the Work, and to take all measures to eliminate such errors as soon as possible.
17. The University undertakes to indicate the names of the Co-authors on all copies of the Work during any public use of the Work. The list of Co-authors may be shortened according to the rules for the formation of bibliographic descriptions determined by the University or third parties.
18. The University undertakes not to violate the integrity of the Work, to agree with the Corresponding Author on all changes made to the Work during processing and editing.
19. In case of violation of their obligations under this Agreement, its parties bear the responsibility defined by this Agreement and the current legislation of Ukraine. All disputes under the Agreement are resolved through negotiations, and if the negotiations do not resolve the dispute – in the courts of the city of Kharkiv.
20. The parties are not responsible for the violation of their obligations under this Agreement, if it occurred through no fault of theirs. The party is considered innocent if it proves that it has taken all measures dependent on it for the proper fulfillment of the obligation.
21. The Co-authors are responsible for the truthfulness of the facts, quotes, references to legislative and regulatory acts, other official documentation, the scientific validity of the Work, all types of responsibility to third parties who have claimed their rights to the Work. The co-authors reimburse the University for all costs caused by claims of third parties for infringement of copyright and other rights to the Work, as well as additional material costs related to the elimination of identified defects.