Comparative analysis of the role of domestic allergens in atopic dermatitis etiology in children


Shmulich V.K., Uryvayva M.K., Lupaltsova O.S., Staruseva V.V., Rybka O.S., Shmulich O.V., Kryvenko L.S.
Comparative analysis of the role of domestic allergens in atopic dermatitis etiology in children
Kharkiv National Medical University, Ukraine

Abstract. Four hundred and thirty-eight children aged 4 to 18 suffering from atopic dermatitis in the sustained remission phase in the course of the disease were studied using the skin prick testing technique. Prevalence of children of pre-school and primary school age with the atopic dermatitis was established. Skin acariasis caused by Dermatophagoides farinae mites prevails which can be used to optimize specific immunotherapy of atopic of dermatitis in children. Children of the senior school age were the least sensitive to A. Daphnia magna. Suitability of the start elimination therapy was proved. The detected age and sex etiological features of (atopic dermatitis) AD in the large population of children related mostly to the prevailing role of domestic triggers suggest the urgent necessity to eliminate the allergens in the residential premises where children suffering from allergic diseases live, as well as in the places where healthy children live, since the long contact with the indoor allergens is potentially hazardous regarding sensitization formation.
Key words: atopic dermatitis, domestic allergens, children.

Шмуліч В.К., Уриваєва М.К., Лупальцова О.С., Старусева В.В., Рибка О.С., Шмуліч О.В., Кривенко Л.С.
Порівняльна характеристика значущості побутових алергенів в етіології атопічного дерматиту у дітей.
Харківський національний медичний університет, Україна

Резюме. Методом prick-test обстежено 438 дітей віком від 4 до 18 років, хворих на атопічний дерматит у період стійкої ремісії встановлено перевагу у захворюваності атопічним дерматитом серед дітей дошкільного та раннього шкільного віку. Серед шкірних акаріазів превалюютьвикликані кліщами роду Dermatophagoides farina, що може бути використано з метою оптимізації специфічної імунотерапії атопічного дерматиту у дітей. Діти старшого шкільного віку найменш чутливі до A.Daphnia magna. Доказана доцільність стартової елімінаційної терапії.
Ключові слова: атопічний дерматит, побутові алергени, діти.

Шмулич В.К., Урываева М.К., Лупальцова О.С., Старусева В.В., Рыбка Е.С., Шмулич О.В., Кривенко Л.С.
Сравнительная характеристика значимости бытовых аллергенов в этиологии атопического дерматита у детей.
Харьковский национальный медицинский университет, Украина

Резюме. Методом prick-test обследовано 438 детей в возрасте от 4 до 18 лет, больных атопическим дерматитом в фазе стойкой ремиссии в течении заболевания. Установлено преобладание в заболеваемости атопическим дерматитом детей дошкольного и раннего школьного возраста. Среди кожных акориазов преобладают вызванные клещами рода Dermatophagoides farina, что может быть использовано с целью оптимизации специфической иммунотерапии атопического дерматита у детей. Дети старшего школьного возраста наименее чувствительны к A.Daphnia magna. Доказана необходимость в стартовой элиминационной терапии.
Ключевые слова: атопический дерматит, бытовые аллергены, дети.


Zajkov, S. Opportunities of the elimination therapy of allergic diseases/ S.V.Zaykov, A.P.Grishilo // Asthma and allergy. - № 1. - 2013. - S. 23-31.

Baxi, S. N. The Role of Allergen Exposure and Avoidance in Asthma [Text] / S. N. Baxi, W. Phipatanakul // Adolesc Med State Art Rev. – 2010. – 21 (1). – P. 57–72.

Gaffin, J. M. The role of indoor allergens in the development of asthma [Text] / J. M. Gaffin, W. Phipatanakul // Curr. Opin. Allergy Clin. Immunol. – 2009. – 9 (2). – P. 128–135.

Platts-Mills, T. А. The role of allergens in asthma [Text] / T. A. Platts-Mills, D. Y. Leung, M. Schatz // Am. Fam. Physician. – 2007. – Vol. 76. – P. 650–680.

Makeeva N.I. Value of house aeroallergens in the etiological spectrum of bronchial asthma in children / Makeeva N.I., Shmulych V.K. // Annals of Mechnikov Institute. - 2013. – 4. – P. 28- 32.

Makeeva N.I. Determining etiologic spectrum of allergic diseases in children depending on sex and age using the nomographic method. / Makeeva N.I., Myasoyedov V.V., Shmulich V.K. // Method Guidelines. - Kyiv, 2013. – P. 43.

Pukhlik B.M. Prophylactics of allergic diseases caused by house allergens [Text] / B.М. Pukhlik // Clinical immunology. Allergology. Infectology. – 2009. – № 3 (22). – P. 57–60.

Rational pharmacotherapy of allergic diseases: Book for practitioners [Text] / Ed. R.M. Haitova, N. Ilina, T.V. Latysheva, L. Luss, etc. - M.: Litterra, 2007. – 504 p. С: 616.248-053.2-022.854.

Application Guidelines “Non-Infectious Domestic Allergens” approved by Order of the Ministry of Health of Ukraine # 197 dd. March 05, 2010. State registration certificate # 198/10-300200000 dd. March 05, 2010.

Copyright for articles published in the journal is regulated by the License Agreement for the use of a scientific article in the journal, which is concluded between the author of the article (Licensor) and Kharkov National Medical University (Licensee, publisher of the journal "Inter Collegas"). The licensor grants to the Licensee a non-exclusive non-exclusive license for the use of the article (a license that does not exclude the use of the article by the Licensor and the issuance of licenses to others for use of this article) on the terms and for the period specified in the contract. The licensor (the author of the article) grants the Licensee the right to reproduce the article (publication in the journal "Inter Collegas", publication, duplication, duplication or other reproduction of the article without limiting the circulation of copies, each copy of the article must contain the name of the Licensor; Of general information, including the publication of the article in full or in part on the Internet on the journal page, the right to use the metadata of the article (titles, full names of authors, annotations, bibliography eskih materials) through the dissemination and communication to the public, processing and systematization, as well as inclusion in various databases and in-formational system).

The licensor grants the licensee the right to transfer, store and process his personal data (full name, scientific degree, academic title, place of work and position, contact information of the authors) with the purpose of including them in the database in accordance with the Law of Ukraine No. 2297 - VI "on protection of personal data" from 01.06.2010.

Personal data and metadata of the article are provided for their storage and processing in various databases and information systems, including them in analytical and statistical reporting, creating sound relationships between the objects of works of science, literature and art with personal data, etc. on unlimited territory. The licensee has the right to transfer the specified data for processing and storage to third parties provided that such a fact is notified with the provision of information about the third party (name and address) to the Licensor.