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Анотація
Серцево-судинна патологія у хворих хронічними обструктивними захворюваннями легень є одним з частих коморбідних станів в клініці внутрішніх хвороб. Висока частота обумовлена як генетичною схильністю, так і загальними факторами ризику (куріння, літній вік, чоловіча стать, малорухливий спосіб життя, ожиріння). У статті показано, що однією з найбільш ранніх фаз патогенезу даної поєднаної патології є розвиток ендотеліальної дисфункції. Дана характеристика ендотеліальної дисфункції, як порушення рівноваги протилежно діючих почав, виникнення «порочних кіл», що порушують гемоваскулярного гемостаз. Обговорено роль активності оксиду азоту, ендотеліну-1, міжклітинної молекули адгезії-1 (ICАM-1), в розвитку ендотеліальної дисфункції хворих на ХОЗЛ.
У статті подано визначення поняття оксидативний стрес, перераховані найважливіші оксиданти і механізми їх шкідливої дії. Особливу увагу приділено 8-ізопростану, як золотого стандарту для оцінки оксидативного стресу у пацієнтів з ХОЗЛ.
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References
Lopez, A. D., Shibuya, K., Rao, C., Mathers, C. D., Hansell, A. L., Held, L. S., ... & Buist, S. (2006). Chronic obstructive pulmonary disease: current burden and future projections. European Respiratory Journal, 27(2), 397-412. doi.org/10.1183/09031936.06.00025805
Mathers, C. D., & Loncar, D. (2006). Projections of global mortality and burden of disease from 2002 to 2030. PLoS medicine, 3(11), e442. doi.org/10.1371/journal.pmed.0030442
Trupin, L., Earnest, G., San Pedro, M., Balmes, J. R., Eisner, M. D., Yelin, E., ... & Blanc, P. D. (2003). The occupational burden of chronic obstructive pulmonary disease. European Respiratory Journal, 22(3), 462-469. doi.org/10.1183/09031936.03.00094203
Dahl, R., Chung, K. F., Buhl, R., Magnussen, H., Nonikov, V., Jack, D., ... & Kramer, B. (2010). Efficacy of a new once-daily long-acting inhaled β2-agonist indacaterol versus twice-daily formoterol in COPD. Thorax, 65(6), 473-479. doi.org/10.1136/thx.2009.125435
Feshhenko, Ju. I. (2009). HOZL v Ukraine: problemy i puti reshenija. Zdorov’ja Ukraїni, 9(1), 3−4 (in Russian).
Global'naja strategija diagnostiki, lechenija i profilaktiki HOBL. Peresmotr 2011 g. Per. s angl. / pod red. A.S. Belevskogo. M.: Rossijskoe respiratornoe obshhestvo, 2012. 80s. [Global Initiative for Chronic Obstructive Lung Diseases. Global Strategy for Diagnosis, Management and Prevention for Chronic Obstructive Lung Diseases (Revised 2011). Rossiyskoe Respiratornoye Obschestvo Publ., 2012 (in Russian)].
Mannino, D. M., Thorn, D., Swensen, A., & Holguin, F. (2008). Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD. European Respiratory Journal, 32(4), 962-969. doi.org/10.1183/09031936.00012408
Ovcharenko, S. I. (2018). Serdechno-sosudistaja patologija u bol'nyh hronicheskoj obstruktivnoj bolezn'ju legkih: kak my lechim?. RMZh, 26(10-1), 36-39 [Ovcharenko, S.I. (2018). Cardiovascular pathology in patients with chronic obstructive pulmonary disease: how do we treat it? RMJ. 10 (I), 36–39] (in Russian).
Babak, O. Ja., Shaposhnikova, Ju. N., & Nemcova, V. D. (2004). Arterial'naja gipertenzija i ishemicheskaja bolezn' serdca-jendotelial'naja disfunkcija: sovremennoe sostojanie voprosa. Ukrainskij terapevticheskij zhurnal, (1), 14-22.
Chuchalin, A. G. (2008). Hronicheskaja obstruktivnaja bolezn' legkih i soputstvujushhie zabolevanija. Pul'monologija, (2), 5-14 (in Russian).
Feary. J, & Branes N. (2009). Abstract, ERS, 19 Annual Congress. sept.13. P. 962.
Brodskaja, T. A., Nevzorova, V. A., Gelcer, B. I., & Motkina, E. V. (2007). Jendotelial'naja disfunkcija i bolezni organov dyhanija. Terapevticheskij arhiv, 79(3), 76-84 (in Russian).
Birben, E., Sahiner, U. M., Sackesen, C., Erzurum, S., & Kalayci, O. (2012). Oxidative stress and antioxidant defense. World Allergy Organization Journal, 5(1), 9-19.doi.org/10.1097/wox.0b013e3182439613
Kovaljova, O. N., Ashcheulova, T. V., Gerasimchuk, N. N., & Safargalina-Kornilo-va, N. A. (2015). Rol'oksidativnogo stressa v stanovlenii i progressirovanii gipertonicheskoj bolezni [Role of oxidative stress in the formation and progression of hypertensive disease]. Nauchnye Vedomosti Belgorodskogo Gosudarstvennogo Universiteta Medicina Farmacija, Aktual'nye problemy mediciny, 29(4(201)), 5-10 (in Russian).
Rahman, I., & Adcock, I. M. (2006). Oxidative stress and redox regulation of lung inflammation in COPD. European respiratory journal, 28(1), 219-242. doi.org/10.1183/09031936.06.00053805
Yin, H. (2008). New techniques to detect oxidative stress markers: mass spectrometry-based methods to detect isoprostanes as the gold standard for oxidative stress in vivo. Biofactors, 34(2), 109-124. doi.org/10.1002/biof.5520340203
Herasymchuk, N. (2018). 8-isoprostane as the main marker of oxidative stress. Zaporozhye medical journal. Volume 20. No. 6 (11), 2018, - 853-859. doi.org/10.14739/2310-1210.2018.6.146780
Horváth, I., Hunt, J., & Barnes, P. J. (2005). Exhaled breath condensate: methodological recommendations and unresolved questions.
European Respiratory Journal,26(3), 523-548. doi.org/10.1183/09031936.05.00029705
Kostikas, K., Papatheodorou, G., Psathakis, K., Panagou, P., & Loukides, S. (2003). Oxidative stress in expired breath condensate of patients with COPD. Chest, 124(4), 1373-1380. doi.org/10.1378/chest.124.4.1373
Montuschi, P., Collins, J. V., Ciabattoni, G., Lazzeri, N., Corradi, M., Kharitonov, S. A., & Barnes, P. J. (2000). Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. American journal of respiratory and critical care medicine, 162(3), 1175-1177.doi.org/10.1164/ajrccm.162.3.2001063
Antczak, A., Ciebiada, M., Pietras, T., Piotrowski, W. J., Kurmanowska, Z., & Górski, P. (2012). Exhaled eicosanoids and biomarkers of oxidative stress in exacerbation of chronic obstructive pulmonary disease. Archives of medical science: AMS, 8(2), 277-285. oi.org/10.5114/aoms.2012.28555
Biernacki, W. A., Kharitonov, S. A., & Barnes, P. J. (2003). Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD. Thorax, 58(4), 294-298. doi.org/10.1136/thorax.58.4.294
Anaev, Je. H., Kushaeva, M. Je., & Kurova, V. S. (2012). Znachenie proteomnogo analiza kondensata vydyhaemogo vozduha pri diagnostike HOBL i pnevmonii. Pul'monologija. 5, 5–9.
Ko, F. W., Lau, C. Y., Leung, T. F., Wong, G. W., Lam, C. W., & Hui, D. S. (2006). Exhaled breath condensate levels of 8-isoprostane, growth related oncogene α and monocyte chemoattractant protein-1 in patients with chronic obstructive pulmonary disease. Respiratory medicine, 100(4), 630-638. doi.org/10.1016/j.rmed.2005.08.009
Wanner, A., & Mendes, E. S. (2010). Airway endothelial dysfunction in asthma and chronic obstructive pulmonary disease: a challenge for future research. American journal of respiratory and critical care medicine, 182(11), 1344-1351. doi.org/10.1164/rccm.201001-0038pp
Malaja, L. T., Korzh, A. N., & Balkovaja, L. B. (2000). Jendotelial'naja disfunkcija pri patologii serdechno-sosudistoj sistemy. Har'kov: Torsing, 432 (in Russian).
Hall C. (2001). The value of natriuretic peptides for the management of heart failure: current state of play. European Journal of Heart Failure. 3(4): 395–397. doi.org/10.1016/s1388-9842(01)00151-9
Ashheulova, T. V., Kovaleva, O. N., Gerasimchuk, N. N., & Safargalina-Kornilova, N. A. (2016). Funkcional'noe sostojanie jendotelija i aktivnost' provospalitel'nyh citokinov u bol'nyh gipertonicheskoj bolezn'ju, associirovannoj s ozhireniem [Endothelial function and activity of proinflammatory cytokines in patients with hypertension associated with obesity]. Nauchnye Vedomosti Belgorodskogo Gosudarstvennogo Universiteta Medicina Farmacija, Aktual'nye problemy mediciny, 34(12 (233)), 5-14 (in Russian).
Ribeiro, F., Alves, A. J., Teixeira, M., Ribeiro, V., Duarte, J. A., & Oliveira, J. (2009). Endothelial function and atherosclerosis: circulatory markers with clinical usefulness. Revista portuguesa de cardiologia: orgao oficial da Sociedade Portuguesa de Cardiologia= Portuguese journal of cardiology: an official journal of the Portuguese Society of Cardiology, 28(10), 1121-1151.
Lapshina, L. A., Molodan, V. I., Shevchenko, O. S., & Nemcova, V. D. (2001). Jendotelial'naja disfunkcija pri nachal'nyh stadijah arterial'noj gipertenzii i sposoby ee nemedikamentoznoj korrekcii. Ukrainskij terapevticheskij zhurnal, 3(4), 39 (in Russian).
Danilenko, S. A., & Landyshev, Ju. S. (2010). Mikrogemocirkuljatornye narushenija v slizistoj obolochke bronhov pri hronicheskoj obstruktivnoj bolezni legkih. Regionarnoe krovoobrashhenie i mikrocirkuljacija, 9(1), 38-41 (in Russian).
Van Suylen, R. J., Smits, J. F., & Daemen, M. J. (1998). Pulmonary artery remodeling differs in hypoxia-and monocrotaline-induced pulmonary hypertension. American journal of respiratory and critical care medicine, 157(5), 1423-1428 (in Russian). doi.org/10.1164/ajrccm.157.5.9709050
Bakakos, P., Patentalakis, G., & Papi, A. (2016). Vascular Biomarkers in Asthma and COPD. Curr Top Med Chem. 16(14), 1599-1609. doi.org/10.2174/1568026616666150930121157
Shao, D., Park, J. E., & Wort, S. J. (2011). The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension. Pharmacological Research, 63(6), 504-511. doi.org/10.1016/j.phrs.2011.03.003
Almagro, P., Cabrera, F. J., Diez, J., Boixeda, R., Ortiz, M. B. A., Murio, C., & Soriano, J. B. (2012). Comorbidities and Short-term Prognosis in Patients Hospitalized for Acute Exacerbation of COPDComorbidity and Prognosis in COPD Hospitalized Patients The EPOC en Servicios de Medicina Interna (ESMI) Study. Chest Journal, 142(5), 1126-1133. doi.org/10.1378/chest.11-2413
Mannino, D. M., & Sanderson, W. T. (2017). Using big data to reveal chronic respiratory disease mortality patterns and identify potential public health interventions. Jama, 318(12), 1112-1114. doi.org/10.1001/jama.2017.11746
Ives, S. J., Harris, R. A., Witman, M. A., Fjeldstad, A. S., Garten, R. S., McDaniel, J., ... & Richardson, R. S. (2014). Vascular dysfunction and chronic obstructive pulmonary disease: the role of redox balance. Hypertension, 63(3), 459-467. doi.org/10.1161/hypertensionaha.113.02255
Barnes, P. J., Shapiro, S. D., & Pauwels, R. A. (2003). Chronic obstructive pulmonary disease: molecular and cellularmechanisms. European Respiratory Journal, 22(4), 672-688. doi.org/10.1183/09031936.03.00040703
Makarova, M. A., Avdeev, S. N., & Chuchalin, A. G. (2014). Arterial'naja rigidnost' i jendotelial'naja disfunkcija u pacientov s hronicheskoj obstruktivnoj bolezn'ju legkih: chto pervichno? [Arterial stiffness and endothelial dysfunction in patients with chronic obstructive pulmonary disease: what is primary and secondary?] Pul'monologija, (6), 73-79 (in Russian). doi.org/10.18093/0869-0189-2011-0-6-73-79
Оеlsnеr, Е.C., Pоttingеr, T.D., Burkаrt, K.M., & Аllisоn, M. (2013). Аdhеsiоnmоlеculеs, еndоthеlin-1 аnd lung functiоni n sеvеn pоpulаtiоn-bаsеdcоhоrts. Biоmаrkеrs; 18 (3), 196–203.
Wаltеr, R.E., Wilk, J.B., Lаrsоn, M.G., & Vаsаn RS. (2008). Systеmic inflаmmаtiоn аnd CОPD: thе Frаminghаm Hеаrt Study. Chеst; 133 (1), 19–25.
Hе, Z. J. H., & Zhi, H. X. Z. (2010). Intеgrin-аssоciаtеd prоtеins in blооd plаsmа оf pаtiеnts with аcutееxаcеrbаtiоn оf chrоnic оbstructivе pulmоnаry disеаsе. Аrticlе in Chinеsе, 33(4), 265-7.
Riise, G. C., Larsson, S., Lofdahl, C. G., & Andersson, B. A. (1994). Circulating cell adhesion molecules in bronchial lavage and serum in COPD patients with chronic bronchitis. European Respiratory Journal, 7(9), 1673-1677. doi.org/10.1183/09031936.94.07091673
Pollock, D. M. (2005). Endothelin, angiotensin, and oxidative stress in hypertension. Hypertension, 45(4), 477-480.
Ashheulova, T. V., Zaika, M. V., & Gerasimchuk, N. N. (2007). Vzaimosvjaz' immunnoj aktivacii i oksidativnogo stressa pri progressirovanii arterial'noj gipertenzii. [The relationship between immune activation and oxidative stress in the progression of arterial hypertension]. Ukrainskij terapevticheskij zhurnal, 2, 12-15 (in Russian).
Barua, R. S., Ambrose, J. A., Eales-Reynolds, L. J., DeVoe, M. C., Zervas, J. G., & Saha, D. C. (2001). Dysfunctional endothelial nitric oxide biosynthesis in healthy smokers with impaired endothelium-dependent vasodilatation. Circulation, 104(16), 1905-1910. doi.org/10.1161/hc4101.097525
Butler, R., Morris, A. D., & Struthers, A. D. (2001). Cigarette smoking in men and vascular responsiveness. British journal of clinical pharmacology, 52(2), 145-149. doi.org/10.1046/j.0306-5251.2001.01434.x
Karoli, N. A., & Rebrov, A. P. (2004). Vlijanie kurenija na razvitie jendotelial'noj disfunkcii u bol'nyh hronicheskoj obstruktivnoj bolezn'ju legkih. Pul'monologija, 2(14), 70-78.
Laurent, S., Katsahian, S., Fassot, C., Tropeano, A. I., Gautier, I., Laloux, B., & Boutouyrie, P. (2003). Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke, 34(5), 1203-1206. doi.org/10.1161/01.str.0000065428.03209.64
Mahendra, M., Kumar, S., Desai, N., Jayaraj, B. S., & Mahesh, P. A. (2018). Evaluation for airway obstruction in adult patients with stable ischemic heart disease. Indian heart journal, 70(2), 266-271. doi.org/10.1016/j.ihj.2017.08.003.
Ratova, L. G., Zykov, K. A., Dolgusheva, Ju. A., Agapova, O. Ju., Nazarov, B. M., & Chazova, I. E. (2012). Arterial'naja gipertonija i bronhoobstruktivnaja patologija-osobennosti klinicheskoj kartiny. Sistemnye gipertenzii, 9(1), 54–59. [Arterial'naya gipertoniya i bronkhoobstruktivnaya patologiya - osobennosti klinicheskoy kartiny] (in Russian). doi.org/10.26442/SG33169
Ovcharenko, S., I., Nersesyan, Z., N., & Morozova, T., E.. (2014). Chronic obstructive pulmonary disease combined with arterial hypertension: efficacy and safety ofthesustained-release indapamide (Arifon® retard) Systemic Hypertension, 11(2).54-58. doi.org/10.26442/sg29026
Triest, F. J., Studnicka, M., Franssen, F. M., Vollmer, W. M., Lamprecht, B., Wouters, E. F., ... & Vanfleteren, L. E. (2019). Airflow obstruction and cardio-metabolic comorbidities. COPD: Journal of Chronic Obstructive Pulmonary Disease, 16(2), 109-117. doi.org/10.1080/15412555.2019.1614550
Malo de Molina, R., Aguado, S., Arellano, C., Valle, M., & Ussetti, P. (2018). Ischemic heart disease during acute exacerbations of COPD. Medical Sciences, 6(4), 83. doi.org/10.3390/medsci6040083
Khassawneh, B. Y., Samrah, S. M., Jarrah, M. I., Ibdah, R. K., Ibnian, A. M., Almistarehi, A. W., ... & Khader, Y. S. (2018). Prevalence of undiagnosed COPD in male patients with coronary artery disease: a cross-sectional study in Jordan. International journal of chronic obstructive pulmonary disease, 13, 2759-2766. doi:10.2147/COPD.S172679 PMCID: PMC6130534.
Biscaglia, S., Ruggiero, R., Di Cesare, A., Serenelli, M., & Ferrari, R. (2019). Angina and chronic obstructive pulmonary disease: facing the perfect storm. European Heart Journal Supplements, 21(Supplement_C), 17-20. doi.org/10.1093/eurheartj/suz042
Almagro, P., De la Sierra, A., Acosta, E., Navarro, A., Garcia, M. E., Valdivieso, S., ... & Agustí, A. (2018). Spirometrically confirmed chronic obstructive pulmonary disease worsens long-term prognosis after percutaneous coronary intervention. American journal of respiratory and critical care medicine, 197(6), 824-826. doi.org/10.1164/rccm.201707-1389le
Andersson, C., Hansen, P. W., Steffensen, I. E., Andreasen, C., Weeke, P. E., Køber, L., ... & Torp-Pedersen, C. (2019). Mortality associated with cardiovascular drugs in patients with chronic obstructive pulmonary disease and right-sided heart failure–A danish nationwide registry-based study. European journal of internal medicine, 63, 56-61. doi.org/10.1016/j.ejim.2019.02.014
Bazargan, M., Smith, J. L., Robinson, P., Uyanne, J., Abdulrahoof, R., Chuku, C., & Assari, S. (2019). Chronic respiratory disease and health-related quality of life of African American older adults in an economically disadvantaged area of Los Angeles. International journal of environmental research and public health, 16(10), 1756. doi.org/10.3390/ijerph16101756
Ellingsen, J., Johansson, G., Larsson, K., Lisspers, K., Malinovschi, A., Ställberg, B., ... & Janson, C. (2020). Impact of Comorbidities and Commonly Used Drugs on Mortality in COPD–Real-World Data from a Primary Care Setting. International journal of chronic obstructive pulmonary disease, 15, 235. doi: 10.2147/COPD.S231296.
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