How to Cite
Abstract
Abstract
Gonchar M.O, Riga O.O., Boychenko A.D, Kondratova I.Yu.,Komova V.A., Buzhinskaya N.R.
CHARACTERISTICS OF THE RISK FACTOR FOR CONGENITAL DISORDERS IN NEWBORNS
Kharkiv National Medical University
In order to objectify risk factors for cardiovascular diseases in newborns the study implied the assessment of mothers’ medical records, labor characteristics, gestational age of 50 newborn infants who died of congenital heart diseases and 50 healthy newborns. The authors determined that fatal outcomeininfants with congenital heart diseases is 5.4 times more likely to occur in physiological pregnancy than innewborns with non-cardiac perinatal abnormalities. But the risk of having a baby with congenital heart disease and unfavorable course increases in comorbidities, typical for pregnancy (2.6 times), acute respiratory viral infections during pregnancy (6.1 times), bacterial and / or viral infections before and during pregnancy (53 times)
Key words: newborns, the risk of congenital heart defects
Резюме
Гончарь М.О., Ріга О.О., Бойченко А.Д., Кондратова І.Ю., Комова В. О., Бужинська Н.Р.
ХАРАКТЕРИСТИКА ФАКТОРІВ РИЗИКУ ДЛЯ РОЗВИТКУ ВРОДЖЕНИХ ВАД СЕРЦЯ
Харківський національний медичний університет
З метою об’єктивізації факторів ризику виникнення серцево-судинної патології у новонароджених визначено анамнез матері, особливості пологів, гестаційний вік у 50 новонароджених дітей, які померли від вроджених вад серця та у 50 здорових новонароджених. Авторами визначено, що народження дітей з вродженими вадами серця, які мають критичний перебіг, у 5,4 разів частіше відбувається при нормальному перебігу вагітності ніж народження дітей з перинатальною патологією некардіального характеру. Але ризик народити дитину з вродженими вадами серця та несприятливим перебігом підвищується якщо у жінок є сполучення патологічних станів, характерних для вагітності (у 2,6 разів); ГРВІ під час вагітності (у 6,1 разів); наявність інфекційних бактеріальних та/або вірусних захворювань до та під час вагітності (у 53 рази).
Ключові слова: новонароджені, ризик вроджених вад серця
Резюме
Гончарь М.А., Рига Е.А., Бойченко А.Д., Кондратова И.Ю., Комова В. А., Бужинская Н.Р.
ХАРАКТЕРИСТИКА ФАКТОРОВ РИСКА ДЛЯ РАЗВИТИЯ ВРОЖДЕННЫХ ПОРОКОВ СЕРДЦА
Харьковский национальный медицинский университет
С целью объективизации факторов риска возникновения сердечно-сосудистой патологии у новорожденных изучен анамнез матери, особенности родов, гестационный возраст у 50 новорожденных детей, умерших от врожденных пороков сердца и у 50 здоровых новорожденных. Авторами установлено, что рождение детей с врожденными пороками сердца, которые имеют критический исход, в 5,4 раза чаще происходит при нормальном течении беременности, чем рождение детей с перинатальной патологией некардиального характера. Но риск родить ребенка с врожденными пороками сердца и неблагоприятным течением повышается, если у женщин имеет место сочетание патологических состояний, характерных для беременности (в 2,6 раз), ОРВИ во время беременности (в 6,1 раз), наличие инфекционных бактериальных и /или вирусных заболеваний до и во время беременности (в 53 раза).
Ключевые слова: новорожденные, риск врожденных пороков сердца
References
Tennant PW, Pearce MS, Bythell M, Rankin J. 20-year
survival of children born with congenital anomalies: a population-
based study. Lancet 2010; 375:649.
Bird TM, Hobbs CA, Cleves MA, et al. National rates of
birth defects among hospitalized newborns. Birth Defects
Res A ClinMolTeratol 2006; 76:762.
Canfield MA, Honein MA, Yuskiv N, et al. National estimates
and race/ethnic-specific variation of selected birth
defects in the United States, 1999-2001. BirthDefectsRes A
ClinMolTeratol 2006; 76:747.
Oster ME, Lee KA, Honein MA, et al. Temporal trends
in survival among infants with critical congenital heart
defects. Pediatrics 2013; 131:e1502.
Wren C, Reinhardt Z, Khawaja K. Twenty-year trends
in diagnosis of life-threatening neonatal cardiovascular
malformations. ArchDisChildFetalNeonatalEd 2008; 93:F33.
Gregory J, Emslie A, Wyllie J, Wren C. Examination for
cardiac malformations at six weeks of age.
ArchDisChildFetalNeonatalEd 1999; 80:F46.
Samánek M, Slavík Z, Zborilová B, et al. Prevalence,
treatment, and outcome of heart disease in live-born children:
a prospective analysis of 91,823 live-born children.
PediatrCardiol 1989; 10:205.
Peterson C, Ailes E, Riehle-Colarusso T, et al. Late
detection of critical congenital heart disease among US
infants: estimation of the potential impact of proposed
universal screening using pulse oximetry. JAMA Pediatr
; 168:361.
Kuehl KS, Loffredo CA, Ferencz C. Failure to diagnose
congenital heart disease in infancy. Pediatrics 1999;
:743.
de-WahlGranelli A, Wennergren M, Sandberg K, et al.
Impact of pulse oximetry screening on the detection of
duct dependent congenital heart disease: a Swedish prospective
screening study in 39,821 newborns. BMJ 2009;
:a3037.
Eckersley L, Sadler L, Parry E, et al. Timing of diagnosis
affects mortality in critical congenital heart disease.
ArchDisChild 2015.
Warnes CA, Williams RG, Bashore TM, et al. ACC/AHA
Guidelines for the Management of Adults with Congenital
Heart Disease: Executive Summary: a report of the
American College of Cardiology/American Heart Association
Task Force on Practice Guidelines (writing committee
to develop guidelines for the management of adults with
congenital heart disease). Circulation 2008; 118:2395.
European Society of Gynecology (ESG), Association for
European Paediatric Cardiology (AEPC), German Society for
Gender Medicine (DGesGM), et al. ESC Guidelines on the
management of cardiovascular diseases during pregnancy:
the Task Force on the Management of Cardiovascular Diseases
during Pregnancy of the European Society of Cardiology
(ESC). EurHeart J 2011; 32:3147.
Drenthen W, Boersma E, Balci A, et al. Predictors of
pregnancy complications in women with congenital heart
disease. EurHeart J 2010; 31:2124.
Siu SC, Sermer M, Harrison DA, et al. Risk and predictors
for pregnancy-related complications in women with
heart disease. Circulation 1997; 96:2789.
Siu S, Chitayat D, Webb G. Pregnancy in women with
congenital heart defects: what are the risks? Heart 1999;
:225.
Shi Q.Y. Congenital heart defects and maternal fever:
systematic review and meta-analysis/Q Y Shi,J B Zhang,Y Q
Mi,YSong,JMaandY L Zhang//Journal of Perinatology34,
-682 (September 2014) |doi:10.1038/jp.2014.76
"Inter Collegas" is an open access journal: all articles are published in open access without an embargo period, under the terms of the CC BY-NC-SA (Creative Commons Attribution ‒ Noncommercial ‒ Share Alike) license; the content is available to all readers without registration from the moment of its publication. Electronic copies of the archive of journals are placed in the repositories of the KhNMU and V.I. Vernadsky National Library of Ukraine.
Copyright Agreement
1. This Agreement on the transfer of rights to use the work from the Co-authors to the publisher (hereinafter the Agreement) is concluded between all the Co-authors of the work, represented by the Corresponding Author, and Kharkiv National Medical University (hereinafter the University), represented by an authorized representative of the Editorial Board of scientific journals (hereinafter the Editorial Board).
2. This Agreement is an accession agreement within the meaning of clause 1 of Article 634 of the Civil Code of Ukraine: that is, a contract, "the terms of which are established by one of the parties in forms or other standard forms, which can be concluded only by joining the other party to the proposed contract as a whole. The other party cannot offer its terms of the contract." The party that established the terms of this contract is the University.
3. If there is more than one author, the authors choose the Corresponding Author, who communicates with the Editorial Board on his own behalf and on behalf of all Co-authors regarding the publication of a written work of a scientific nature (article or review, hereinafter referred to as the Work).
4. The contract begins from the moment of submission of the manuscript of the Work by the Corresponding Author to the Editorial Board, which confirms the following:
4.1. all Co-authors of the Work are familiar with and agree with its content, at all stages of reviewing and editing the manuscript and the existence of the published Work;
4.2. all Co-authors of the Work are familiar with and agree to the terms of this Agreement.
5. The published Work is in electronic form in public access on the websites of the University and any websites and electronic databases in which the Work is posted by the University and is available to readers under the terms of the "Creative Commons" license (Attribution NonCommercial Sharealike 4.0 International)" or more free licenses "Creative Commons 4.0".
6. The Corresponding Author transfers, and the University receives, the non-exclusive property right to use the Work by placing the latter on the University's websites for the entire term of copyright. The University participates in the creation of the final version of the Work by reviewing and editing the manuscript of the article or review provided to the Editorial Board by the Corresponding Author, translating the Work into any languages. For the participation of the University in the finalization of the Work, the Co-authors agree to pay the invoice issued to them by the University, if such payment is provided by the University. The size and procedure of such payment are not the subject of this contract.
7. The University has the right to reproduce the Work or its parts in electronic and printed forms, to make copies, permanent archival storage of the Work, distribution of the Work on the Internet, repositories, scientometric databases, commercial networks, including for monetary compensation from third parties.
8. The co-authors guarantee that the manuscript of the Work does not use works whose copyright belongs to third parties.
9. The authors of the Work guarantee that at the time of submission of the manuscript of the Work to the Editorial Board, the property rights to the Work belong only to them, neither in whole nor in part have they been transferred to anyone (not alienated), they are not the subject of a lien, litigation or claims by third parties.
10. The Work may not be posted on the University's website if it violates a person's right to the privacy of his personal and family life, harms public order and health.
11. The work may be withdrawn by the Editorial Board from the University websites, libraries and electronic databases where it was placed by the Editorial Board, in cases of detection of violations of the ethics of the authors and researchers, without any compensation for the losses of the Co-authors. At the time of submission of the manuscript to the Editorial Board and all stages of its editing and review, the manuscript must not have already been published or submitted to other editorial offices.
12. The right transferred under this Agreement extends to the territory of Ukraine and foreign countries.
13. The rights of Co-authors include the requirement to indicate their names on all copies of the Work or during any public use or public mention of the Work; the requirement to preserve the integrity of the Work; legal opposition to any distortion or other encroachment on the Work, which may harm the honor and reputation of the Co-authors.
14. Co-authors have the right to control their personal non-property rights by familiarizing themselves with the text (content) and form of the Work before its publication on the University's website, when transferring it to a printing company for reproduction or when using the Work in other ways.
15. The Co-authors, in addition to the property rights not transferred under this Agreement and taking into account the non-exclusive nature of the rights transferred under this Agreement, retain the property rights to finalize the Work and to use certain parts of the Work in other works created by the Co-authors.
16. The Co-authors are obliged to notify the Editorial Board of all errors in the Work, discovered by them independently after the publication of the Work, and to take all measures to eliminate such errors as soon as possible.
17. The University undertakes to indicate the names of the Co-authors on all copies of the Work during any public use of the Work. The list of Co-authors may be shortened according to the rules for the formation of bibliographic descriptions determined by the University or third parties.
18. The University undertakes not to violate the integrity of the Work, to agree with the Corresponding Author on all changes made to the Work during processing and editing.
19. In case of violation of their obligations under this Agreement, its parties bear the responsibility defined by this Agreement and the current legislation of Ukraine. All disputes under the Agreement are resolved through negotiations, and if the negotiations do not resolve the dispute – in the courts of the city of Kharkiv.
20. The parties are not responsible for the violation of their obligations under this Agreement, if it occurred through no fault of theirs. The party is considered innocent if it proves that it has taken all measures dependent on it for the proper fulfillment of the obligation.
21. The Co-authors are responsible for the truthfulness of the facts, quotes, references to legislative and regulatory acts, other official documentation, the scientific validity of the Work, all types of responsibility to third parties who have claimed their rights to the Work. The co-authors reimburse the University for all costs caused by claims of third parties for infringement of copyright and other rights to the Work, as well as additional material costs related to the elimination of identified defects.