CHARACTERISTICS OF THE RISK FACTOR FOR CONGENITAL DISORDERS IN NEWBORNS

Abstract

Abstract

Gonchar M.O, Riga O.O., Boychenko A.D, Kondratova I.Yu.,Komova V.A., Buzhinskaya N.R.

CHARACTERISTICS OF THE RISK FACTOR FOR CONGENITAL DISORDERS IN NEWBORNS

Kharkiv National Medical University

 

In order to objectify risk factors for cardiovascular diseases in newborns the study implied the assessment of mothers’ medical records, labor characteristics, gestational age of 50 newborn infants who died of congenital heart diseases and 50 healthy newborns. The authors determined that fatal outcomeininfants with congenital heart diseases is 5.4 times more likely to occur in physiological pregnancy than innewborns with non-cardiac perinatal abnormalities. But the risk of having a baby with congenital heart disease and unfavorable course increases in comorbidities, typical for pregnancy (2.6 times), acute respiratory viral infections during pregnancy (6.1 times), bacterial and / or viral infections before and during pregnancy (53 times)

 

Key words: newborns, the risk of congenital heart defects

 

Резюме

Гончарь М.О., Ріга О.О., Бойченко А.Д., Кондратова І.Ю., Комова В. О., Бужинська Н.Р.

ХАРАКТЕРИСТИКА ФАКТОРІВ РИЗИКУ ДЛЯ РОЗВИТКУ ВРОДЖЕНИХ ВАД СЕРЦЯ

Харківський національний медичний університет

 

З метою об’єктивізації факторів ризику виникнення серцево-судинної патології у новонароджених визначено анамнез матері, особливості пологів, гестаційний вік у 50 новонароджених дітей, які померли від вроджених вад серця та у 50 здорових новонароджених. Авторами визначено, що народження дітей з вродженими вадами серця, які мають критичний перебіг, у 5,4 разів частіше відбувається при нормальному перебігу вагітності ніж народження дітей з перинатальною патологією некардіального характеру. Але ризик народити дитину з вродженими вадами серця та несприятливим перебігом підвищується якщо у жінок є сполучення патологічних станів, характерних для вагітності (у 2,6 разів); ГРВІ під час вагітності (у 6,1 разів); наявність інфекційних бактеріальних та/або вірусних захворювань до та під час вагітності (у 53 рази).

Ключові слова: новонароджені, ризик вроджених вад серця

 

Резюме

Гончарь М.А., Рига Е.А., Бойченко А.Д., Кондратова И.Ю., Комова В. А., Бужинская Н.Р.

ХАРАКТЕРИСТИКА ФАКТОРОВ РИСКА ДЛЯ РАЗВИТИЯ ВРОЖДЕННЫХ ПОРОКОВ СЕРДЦА

Харьковский национальный медицинский университет

 

С целью объективизации факторов риска возникновения сердечно-сосудистой патологии у новорожденных изучен анамнез матери, особенности родов, гестационный возраст у 50 новорожденных детей, умерших от врожденных пороков сердца и у 50 здоровых новорожденных. Авторами установлено, что рождение детей с врожденными пороками сердца, которые имеют критический исход, в 5,4 раза чаще происходит при нормальном течении беременности, чем рождение детей с перинатальной патологией некардиального характера. Но риск родить ребенка с врожденными пороками сердца и неблагоприятным течением повышается, если у женщин имеет место сочетание патологических состояний, характерных для беременности (в 2,6 раз), ОРВИ во время беременности (в 6,1 раз), наличие инфекционных бактериальных и /или вирусных заболеваний до и во время беременности (в 53 раза).

 

Ключевые слова: новорожденные, риск врожденных пороков сердца

https://doi.org/10.35339/ic.3.1.35-39
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References

Tennant PW, Pearce MS, Bythell M, Rankin J. 20-year

survival of children born with congenital anomalies: a population-

based study. Lancet 2010; 375:649.

Bird TM, Hobbs CA, Cleves MA, et al. National rates of

birth defects among hospitalized newborns. Birth Defects

Res A ClinMolTeratol 2006; 76:762.

Canfield MA, Honein MA, Yuskiv N, et al. National estimates

and race/ethnic-specific variation of selected birth

defects in the United States, 1999-2001. BirthDefectsRes A

ClinMolTeratol 2006; 76:747.

Oster ME, Lee KA, Honein MA, et al. Temporal trends

in survival among infants with critical congenital heart

defects. Pediatrics 2013; 131:e1502.

Wren C, Reinhardt Z, Khawaja K. Twenty-year trends

in diagnosis of life-threatening neonatal cardiovascular

malformations. ArchDisChildFetalNeonatalEd 2008; 93:F33.

Gregory J, Emslie A, Wyllie J, Wren C. Examination for

cardiac malformations at six weeks of age.

ArchDisChildFetalNeonatalEd 1999; 80:F46.

Samánek M, Slavík Z, Zborilová B, et al. Prevalence,

treatment, and outcome of heart disease in live-born children:

a prospective analysis of 91,823 live-born children.

PediatrCardiol 1989; 10:205.

Peterson C, Ailes E, Riehle-Colarusso T, et al. Late

detection of critical congenital heart disease among US

infants: estimation of the potential impact of proposed

universal screening using pulse oximetry. JAMA Pediatr

; 168:361.

Kuehl KS, Loffredo CA, Ferencz C. Failure to diagnose

congenital heart disease in infancy. Pediatrics 1999;

:743.

de-WahlGranelli A, Wennergren M, Sandberg K, et al.

Impact of pulse oximetry screening on the detection of

duct dependent congenital heart disease: a Swedish prospective

screening study in 39,821 newborns. BMJ 2009;

:a3037.

Eckersley L, Sadler L, Parry E, et al. Timing of diagnosis

affects mortality in critical congenital heart disease.

ArchDisChild 2015.

Warnes CA, Williams RG, Bashore TM, et al. ACC/AHA

Guidelines for the Management of Adults with Congenital

Heart Disease: Executive Summary: a report of the

American College of Cardiology/American Heart Association

Task Force on Practice Guidelines (writing committee

to develop guidelines for the management of adults with

congenital heart disease). Circulation 2008; 118:2395.

European Society of Gynecology (ESG), Association for

European Paediatric Cardiology (AEPC), German Society for

Gender Medicine (DGesGM), et al. ESC Guidelines on the

management of cardiovascular diseases during pregnancy:

the Task Force on the Management of Cardiovascular Diseases

during Pregnancy of the European Society of Cardiology

(ESC). EurHeart J 2011; 32:3147.

Drenthen W, Boersma E, Balci A, et al. Predictors of

pregnancy complications in women with congenital heart

disease. EurHeart J 2010; 31:2124.

Siu SC, Sermer M, Harrison DA, et al. Risk and predictors

for pregnancy-related complications in women with

heart disease. Circulation 1997; 96:2789.

Siu S, Chitayat D, Webb G. Pregnancy in women with

congenital heart defects: what are the risks? Heart 1999;

:225.

Shi Q.Y. Congenital heart defects and maternal fever:

systematic review and meta-analysis/Q Y Shi,J B Zhang,Y Q

Mi,YSong,JMaandY L Zhang//Journal of Perinatology34,

-682 (September 2014) |doi:10.1038/jp.2014.76

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