CLINICAL MASKS OF ACUTE LEUKEMIA IN CHILDREN

Abstract

CLINICAL MASKS OF ACUTE LEUKEMIA IN CHILDREN

Makieieva N.I., Afanasieva O.O., Koval V.A.

For the study of initial clinical signs of acute leukemia in children 92 case histories have been analyzed. In most children the disease manifested with intoxication (94.6 ± 2,3%), lymphadenopathy (84,8±4,7%), hepatosplenomegaly (96,7±2,3%), anemic (82,6±4,9%), haemorrhagic (77,2±5,4%) syndromes. However, only in half of the cases the correct diagnosis was established in period less than 2-3 weeks since the first symptoms appeared. Consequently, it is necessary to pay attention of general practitioners to the variety of non-specific initial symptoms of acute leukemia in children.

Keywords: acute leukemia, children, diagnostics, clinical symptoms

 

КЛИНИЧЕСКИЕ МАСКИ ОСТРОГО ЛЕЙКОЗА У ДЕТЕЙ

Макеева Н.И., Афанасьева О.А., Коваль В.А.

Для изучения начальных клинических признаков острого лейкоза у детей были проанализировано 92 истории болезни. В большинстве случаев заболевание начиналось с интоксикации (94,6 ± 2,3%), лимфаденопатии (84,8 ± 4,7%), гепатоспленомегалии (96,7±2,3%), анемического (82,6 ± 4,9) и геморрагического (77,2 ± 5,4) синдромов. Тем не менее, только в половине случаев правильный диагноз был установлен в период менее чем за 2-3 недели с момента появления первых симптомов. Следовательно, необходимо обратить внимание врачей общей практики на различные неспецифические начальные симптомы острого лейкоза у детей.

Ключевые слова: острый лейкоз, дети, диагностика, клинические симптомы.

 

КЛІНІЧНІ МАСКИ ГОСТРОЇ ЛЕЙКЕМІЇ У ДІТЕЙ

Макєєва Н.І., Афанасьєва О.О., Коваль В.А.

Для вивчення початкових клінічних ознак гострої лейкемії у дітей було проаналізовано 92 історії хвороби. У більшості випадків захворювання починалося з інтоксикації (94,6 ± 2,3%), лімфаденопатії (84,8 ± 4,7%), гепатоспленомегалії (96,7 ± 2,3%), анемічного (82,6 ± 4, 9) та геморагічного (77,2 ± 5,4) синдромів. Проте, тільки в половині випадків правильний діагноз був встановлений в період менш ніж за 2-3 тижні з моменту появи перших симптомів. Отже, необхідно звернути увагу лікарів загальної практики на різні неспецифічні початкові симптоми гострої лейкемії у дітей.

Ключові слова: гостра лейкемія, діти, діагностика, клінічні симптоми

 

https://doi.org/10.35339/ic.4.1.9-13
PDF

References

Fedorenko Zoja P., Michailovich Youriy Yo., Goulak Lyudmyla O., Gorokh Yevgeniy L., Ryzhov Anton Yu., Soumkina Olena V., Koutsenko Lyubov B. (2016) Bulletin of National Cancer Registry of Ukraine (english) vol.17 "Cancer in Ukraine, 2014-2015". http://www.ncru.inf.ua/publications/BULL_17/index_e.htm

Howlader N., Noone A.M., Krapcho M., Miller D., Bishop K., Altekruse S.F., … Cronin K.A. (2016) SEER Cancer Statistics Review, 1975-2013, National Cancer Institute. http://seer.cancer.gov/csr/1975_2013

Dang-Tan T., Franco E.L. (2007) Diagnosis delays in childhood cancer. Cancer. 110, 703–713.

Buntinx F., Mant D., Van den Bruel A., Donner-Banzhof N., Dinant G.J. (2011) Dealing with low-incidence serious diseases in general practice. British Journal of General Practice, 61(582), 43-46.

Feltbower R.G., Lewis I.J., Picton S., Richards M., Glaser A.W., Kinsey S.E., McKinney P.A. (2004) Diagnosing childhood cancer in primary care-a realistic expectation? British Journal of Cancer, 90(10), 1882-1884.

Ahrensberg J.M., Schrøder H., Hansen R.P., Olesen F., Vedsted P. (2012) The initial cancer pathway for children - one-fourth wait more than 3 months. Acta Paediatrica, 101(6), 655-662.

Riccio I., Marcarelli M., Del Regno N., Fusco C., Di Martino M., Savarese R., … Riccardi G. (2013) Musculoskeletal problems in pediatric acute leukemia. Journal of Pediatric Orthopaedics B, 22(3), 264-269. doi: 10.1097/BPB.0b013e32835d731c.

Salim H., Ariawati K., Suryawan W.B., Arimbawa M. (2014) Osteoporosis resulting from acute lymphoblastic leukemia in a 7-year-old boy: a case report. Journal of Medical Case Reports, 8, 168. doi: 10.1186/1752-1947-8-168.

Brix N., Rosthøj S., Herlin T., Hasle H. (2015) Arthritis as presenting manifestation of acute lymphoblastic leukaemia in children. Archives of Disease in Childhood, 100(9), 821-825. doi: 10.1136/archdischild-2014-307751.

Tamashiro M.S., Aikawa N.E., Campos L.M., Cristofani L.M., Odone-Filho V., Silva C.A. (2011) Discrimination of acute lymphoblastic leukemia from systemic-onset juvenile idiopathic arthritis at disease onset. Clinics (Sao Paulo), 66(10), 1665-1669.

Clarke R.T., Jones C.H., Mitchell C.D., Thompson M.J. (2014) ‘Shouting from the roof tops': a qualitative study of how children with leukaemia are diagnosed in primary care. BMJ Open, 4(2). doi: 10.1136/bmjopen-2013-004640.

Copyright for articles published in the journal is regulated by the License Agreement for the use of a scientific article in the journal, which is concluded between the author of the article (Licensor) and Kharkov National Medical University (Licensee, publisher of the journal "Inter Collegas"). The licensor grants to the Licensee a non-exclusive non-exclusive license for the use of the article (a license that does not exclude the use of the article by the Licensor and the issuance of licenses to others for use of this article) on the terms and for the period specified in the contract. The licensor (the author of the article) grants the Licensee the right to reproduce the article (publication in the journal "Inter Collegas", publication, duplication, duplication or other reproduction of the article without limiting the circulation of copies, each copy of the article must contain the name of the Licensor; Of general information, including the publication of the article in full or in part on the Internet on the journal page, the right to use the metadata of the article (titles, full names of authors, annotations, bibliography eskih materials) through the dissemination and communication to the public, processing and systematization, as well as inclusion in various databases and in-formational system).

The licensor grants the licensee the right to transfer, store and process his personal data (full name, scientific degree, academic title, place of work and position, contact information of the authors) with the purpose of including them in the database in accordance with the Law of Ukraine No. 2297 - VI "on protection of personal data" from 01.06.2010.

Personal data and metadata of the article are provided for their storage and processing in various databases and information systems, including them in analytical and statistical reporting, creating sound relationships between the objects of works of science, literature and art with personal data, etc. on unlimited territory. The licensee has the right to transfer the specified data for processing and storage to third parties provided that such a fact is notified with the provision of information about the third party (name and address) to the Licensor.