SIGNS OF INFLAMATION IN THE AIRWAYS IN CHILDREN WITH EXERCISE-INDUCED BRONCHIAL ASTHMA

Abstract

SIGNS OF INFLAMATION IN THE AIRWAYS IN CHILDREN WITH EXERCISE-INDUCED BRONCHIAL ASTHMA

Garas M.N., Bilous T.M., Lekhkun G.V.

In the article based on examination of 102 children with bronchial asthma was defined indices of inflammatory activity of the airways and was set the diagnostic value of these indices as tests for verification exercise-induced bronchial asthma. It was shown that the children with no signs of exercise-induced asthma compared to patients having them, experience some changes in the exhaled breath condensate, indicating a higher activity of inflammation in the airways. The content of nitrogen monoxide metabolites less than 50 mcmol/L or markers of proteolytic activity by azocol lysis less than 0,2 ml/hour in pulmonary expiration products increase the chances of having exercise-induced bronchial asthma phenotype with these tests sensitivity within 66,7-75,7%.

Key words: exercise-induced bronchial asthma, children, diagnostics, inflammation of airways, pulmonary expiration.

 

ПОКАЗНИКИ АКТИВНОСТІ ЗАПАЛЬНОГО ПРОЦЕСУ ДИХАЛЬНИХ ШЛЯХІВ У ДІТЕЙ, ХВОРИХ НА БРОНХІАЛЬНУ АСТМУ ФІЗИЧНОЇ НАПРУГИ 

Гарас М.Н., Білоус Т.М., Лехкун Г.В.

У статті на підставі обстеження 102 дітей, хворих на бронхіальну астму, було визначено показники активності запального процесу дихальних шляхів, а також установлено діагностичну цінність даних показників як тестів по верифікації бронхіальної астми фізичної напруги. Установлено, що у дітей без ознак бронхіальної астми фізичної напруги порівняно з пацієнтами за їх наявності виявляються зміни у конденсаті видихуваного повітря, що свідчать про вищу активність запального процесу в дихальних шляхах. Уміст у легеневому експіраті метаболітів монооксиду нітрогену менше 50 мкмоль/л або маркерів протеолітичної активності за лізисом азоколу менше 0,2 мл/год у два рази підвищують шанси наявності фенотипу астми фізичної напруги при чутливості даних тестів у межах 66,7-75,7%.

Ключові слова: бронхіальна астма фізичної напруги, діти, діагностика, запалення дихальних шляхів, легеневий експірат.

 

ПОКАЗАТЕЛИ АКТИВНОСТИ ВОСПАЛИТЕЛЬНОГО ПРОЦЕССА ДЫХАТЕЛЬНЫХ ПУТЕЙ У ДЕТЕЙ, БОЛЬНЫХ БРОНХИАЛЬНОЙ АСТМОЙ ФИЗИЧЕСКОГО НАПРЯЖЕНИЯ.

Гарас Н.Н., Билоус Т.М., Лехкун Г.В.

В статье на основании обследования 102 детей, больных бронхиальной астмой, были определены показатели активности воспалительного процесса дыхательных путей, а также установлена диагностическую ценность данных показателей как тестов по верификации бронхиальной астмы физического напряжения. Показано, что у детей без признаков бронхиальной астмы физического напряжения по сравнению с пациентами при их наличии выявляются изменения в конденсате выдыхаемого воздуха, которые свидетельствуют о более высокой активности воспалительного процесса в дыхательных путях. Содержание в легочном экспиратов метаболитов окиси азота меньше 50 мкмоль/л или маркеров протеолитической активности по лизису азокола меньше 0,2 мл/ч в два раза повышают шансы наличии фенотипа астмы физического напряжения при чувствительности данных тестов в пределах 66,7-75,7%.

Ключевые слова: бронхильная астма физического напряжения, воспаление дыхательных путей, дети, диагностика, легочный экспират.

https://doi.org/10.35339/ic.4.1.14-19
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References

McFadden, E.R., Gilbert, I.A. (1994). Exercise-induced asthma. Northern England Journal of Medicine, 330(19), 1362-1367.

Anderson, S. (2005). Exercise-induced bronchoconstriction: pathogenesis. Curr. Opin. Allergy Asthma Rep., 5, 116-122.

Panrsons, J.P., Mastronarde, J.Y. (2005). Exercise-induced bronchoconstriction in athletes. Chest, 128, 3966-3974.

Yotshall, R.W. (2002). Exercise-induced bronchoconstriction. Drugs, 2002, 62, 1725-1739.

Rundell, K.W., Jenkinson, D. M. (2002). Exercise-induced bronchospasm in the elite athlete. Sports Medicine, 32, 583-600.

Hallstrand, T.S., Moody, M.W., Wurfer, M.M. (2005). Inflammatory basis of exercise-induced bronchoconstriction. American Journal of Respiratory Critical Care Medicine, 172(6), 679-686.

Cararo, S., Corradi, M., Zanconato S. (2005). Exhaled breath condensate cysteinyl leukotrienes are increased in children with exercise-induced bronchoconstriction / Journal of Alergy and Clinical Immunology, 115, 764-770.

Shin H.-W., Schwindt, C.D., Aledia, A.S. (2006). Exercise-induced bronchoconstriction alters airway nitric oxide exchange in a pattern distinct from spirometry. American Journal Physiol. Regul. Integr. Comp. Physiol., 291, 1741-1748.

Scollo, M., Zanconato, S., Ongaro, K. (1999). Exhaled nitric oxide and exercise-induced bronchoconstriction in asthmatic children. American Journal of Respiratory Critical Care Medicine, 161, 1047-1050.

Terada, A., Fujisawa, T., Togashi, K. (2001). Exhaled nitric oxide decreased during exercise-induced bronchoconstriction in children with asthma. American Journal of Respiratory Critical Care Medicine, 164, 1879-1884.

Buchvald, G., Hermansen, M.N., Nielson, K.Y. (2005). Exhaled nitric oxide predicts exercise-induced bronchoconstriction in asthmatic children. Chest, 128, 1964-1967.

Global strategy for asthma management and prevention. (2006). Retrieved from http: // www.ginasthma.org.

Global Initiative for Asthma. Global strategy for asthma management and prevention (2009). Retrieved from http: // www.ginasthma.org.

Global Initiative for Asthma: Global strategy for asthma management and prevention. Global Initiative for Asthma. (2010). Retrieved from http: // www.ginasthma.org/pdf/GINA_Report_010.pdf.

National Asthma Education and Prevention Program. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. U. S. Department of Health and Human Services; National Heart, Lung, and Blood Institute. NIH Publication Number 09-7147 (2008). Retrieved from http: // nhlbi.nih.gov›files/docs/guidelines/gip_rpt.pdf.

Papadopoulos, N. G., Arakawa, H., Carlsen, K.-H. (2012). International consensus on (ICON) pediatric asthma. Allergy, 67, 976–997.

Bacharier, L.B., Boner, A., Carlsen, K.H. (2008). Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report. Allergy, 63, 5-34.

Babl, F.E., Sheriff, N., Borland, M. (2008). Paediatric acute asthma management in Australia and New Zealand: practice patterns in the context of clinical practice guidelines. Arch. Dis. Child., 93(4), 307-312.

Turner, S., Paton, J., Higgins, B., Douglas, G. (2011). British guidelines on the management of asthma: what’s new for 2011 S. Thorax Online First. Retrieved from http: // 10.1136/thoraxjnl-2011-200213.

Kondo, N., Nishimuta, T., Nishima, S. (2010). Japanese pediatric guidelines for the treatment and management of bronchial asthma. Pediatrics International, 52(2), 319–326.

Almqvist, C., Worm, M., Leynaert, B. (2008). Impact of gender on asthma in childhood and adolescence: a GA2LEN review. Allergy, 63, 47–57.

Lowry, O.H., Rosebrough, N.J., Farr, A.L. (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275.

Emchenko N.L., Czyganenko O.Y., Kovalevskaya T.V. (1994). Unyversal`nij metod opredelenyya nytratov v biosredax organizma [Universal method for the determination of nitrate in biological media of the organism]. Klinicheskaya i laboratornaya diagnostika, no 6, pp. 19-20.

Magalyas V.M., Mixeyev A.O., Rogovy`j Yu.Ye. (2001). Suchasni metodyky eksperymental`nyh ta klinichnyh doslidzhen` central`noyi naukovo-doslidnoyi laboratoriyi BDMA [Modern methods of experimental and clinical trials of the central research laboratory at BSMA], Chernivci, pp. 1-42.

Dubinina E.E., Burmistrov S.O., Porotov Y.G. (1995). Okislitel`naya modifikaciya belkov syvorotki krovi cheloveka, metod eyo opredeleniya [Oxidative modification of proteins of human serum, the method of its determination]. Voprosy medicinskoj himii. no 41(1), pp. 24-26.

Korolyuk M.A., Ivanova L.Y., Majorova Y.G. (1988). Metod opredeleniya aktivnosti katalazy [The method for determining the activity of catalase]. Laboratornoe delo. no 1, pp. 16-19.

Hallstrand, T.S., Moody, M. W., Wurfel, M. M. (2005) Inflammatory basis of exercise-induced bronchoconstriction. American Journal of Respiratory Critical Care Medicine, 172(6), 679-686.

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