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Abstract
SIGNS OF INFLAMATION IN THE AIRWAYS IN CHILDREN WITH EXERCISE-INDUCED BRONCHIAL ASTHMA
Garas M.N., Bilous T.M., Lekhkun G.V.
In the article based on examination of 102 children with bronchial asthma was defined indices of inflammatory activity of the airways and was set the diagnostic value of these indices as tests for verification exercise-induced bronchial asthma. It was shown that the children with no signs of exercise-induced asthma compared to patients having them, experience some changes in the exhaled breath condensate, indicating a higher activity of inflammation in the airways. The content of nitrogen monoxide metabolites less than 50 mcmol/L or markers of proteolytic activity by azocol lysis less than 0,2 ml/hour in pulmonary expiration products increase the chances of having exercise-induced bronchial asthma phenotype with these tests sensitivity within 66,7-75,7%.
Key words: exercise-induced bronchial asthma, children, diagnostics, inflammation of airways, pulmonary expiration.
ПОКАЗНИКИ АКТИВНОСТІ ЗАПАЛЬНОГО ПРОЦЕСУ ДИХАЛЬНИХ ШЛЯХІВ У ДІТЕЙ, ХВОРИХ НА БРОНХІАЛЬНУ АСТМУ ФІЗИЧНОЇ НАПРУГИ
Гарас М.Н., Білоус Т.М., Лехкун Г.В.
У статті на підставі обстеження 102 дітей, хворих на бронхіальну астму, було визначено показники активності запального процесу дихальних шляхів, а також установлено діагностичну цінність даних показників як тестів по верифікації бронхіальної астми фізичної напруги. Установлено, що у дітей без ознак бронхіальної астми фізичної напруги порівняно з пацієнтами за їх наявності виявляються зміни у конденсаті видихуваного повітря, що свідчать про вищу активність запального процесу в дихальних шляхах. Уміст у легеневому експіраті метаболітів монооксиду нітрогену менше 50 мкмоль/л або маркерів протеолітичної активності за лізисом азоколу менше 0,2 мл/год у два рази підвищують шанси наявності фенотипу астми фізичної напруги при чутливості даних тестів у межах 66,7-75,7%.
Ключові слова: бронхіальна астма фізичної напруги, діти, діагностика, запалення дихальних шляхів, легеневий експірат.
ПОКАЗАТЕЛИ АКТИВНОСТИ ВОСПАЛИТЕЛЬНОГО ПРОЦЕССА ДЫХАТЕЛЬНЫХ ПУТЕЙ У ДЕТЕЙ, БОЛЬНЫХ БРОНХИАЛЬНОЙ АСТМОЙ ФИЗИЧЕСКОГО НАПРЯЖЕНИЯ.
Гарас Н.Н., Билоус Т.М., Лехкун Г.В.
В статье на основании обследования 102 детей, больных бронхиальной астмой, были определены показатели активности воспалительного процесса дыхательных путей, а также установлена диагностическую ценность данных показателей как тестов по верификации бронхиальной астмы физического напряжения. Показано, что у детей без признаков бронхиальной астмы физического напряжения по сравнению с пациентами при их наличии выявляются изменения в конденсате выдыхаемого воздуха, которые свидетельствуют о более высокой активности воспалительного процесса в дыхательных путях. Содержание в легочном экспиратов метаболитов окиси азота меньше 50 мкмоль/л или маркеров протеолитической активности по лизису азокола меньше 0,2 мл/ч в два раза повышают шансы наличии фенотипа астмы физического напряжения при чувствительности данных тестов в пределах 66,7-75,7%.
Ключевые слова: бронхильная астма физического напряжения, воспаление дыхательных путей, дети, диагностика, легочный экспират.
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