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Abstract
THORACO-OMPHALOPAGUS CONJOINED TWINS (CASE REPORT)
Petrenko O.O., Petrenko A.O., Harmatina E.O.
Conjoined twins are formed during an impairment in embryo division process. There are some risk factors considered to increase conjoined twins’ formation rate. However, further investigation of genetic processes same as teratogenic agents involved in it is required. In this case an 18-year old patient with the first pregnancy, having no apparent teratogenic factors or family anamnesis with diagnosed conjoined twins is presented. An abortion was performed on the 13th-14th weeks of gestation. Multiple malformations of conjoined twins were studied and genetic counseling was prescribed to the patient during planning of the next pregnancy.
Conjoined twins are formed during an impairment in embryo division process. There are some risk factors considered to increase conjoined twins’ formation rate. However, further investigation of genetic processes same as teratogenic agents involved in it is required. In this case an 18-year old patient with the first pregnancy, having no apparent teratogenic factors or family anamnesis with diagnosed conjoined twins is presented. An abortion was performed on the 13th-14th weeks of gestation. Multiple malformations of conjoined twins were studied and genetic counseling was prescribed to the patient during planning of the next pregnancy.
Keywords: conjoined twins, thoraco-omphalopagus twins, malformations.
СИАМСКИЕ БЛИЗНЕЦЫ ТОРАКООМФАЛОПАГИ (КЛИНИЧЕСКИЙ СЛУЧАЙ)
Петренко А.А., Петренко А.О., Гарматина Е.А.
Сиамские близнецы образуются вследствие нарушения в процессе деления эмбриона. Есть некоторые факторы риска, которые, согласно исследованиям, увеличивают частоту образования сиамских близнецов. Однако требуется дальнейшее исследование вовлечённых в процесс генетических механизмов, а также тератогенных агентов. В данном клиническом случае представлены данные 18-летней пациентки с первой беременностью, не имеющей никаких очевидных тератогенных факторов или семейного анамнеза, у которой диагностированы сиамские близнецы. Аборт производился на 13-14 неделе беременности. Были исследованы аномалии развития сиамских близнецов, пациенту было рекомендовано генетическое консультирование перед планированием следующей беременности.
Ключевые слова: сиамские близнецы, торакоомфалопаги, аномалии развития.
СІАМСЬКІ БЛИЗНЮКИ ТОРАКООМФАЛОПАГИ (КЛІНІЧНИЙ ВИПАДОК)
Петренко О.О., Петренко А.О., Гарматіна Є.О.
Сіамські близнюки утворюються внаслідок порушення в процесі ділення ембріона. Є деякі фактори ризику, які, згідно з дослідженнями, збільшують частоту утворення сіамських близнюків. Однак потрібно подальше дослідження залучених в процес генетичних механізмів, а також тератогенних агентів. В даному клінічному випадку представлені дані 18-річної пацієнтки з першою вагітністю без будь-яких очевидних тератогенних факторів або сімейного анамнезу, у якій виявилися сіамські близнюки. Аборт проводився на 13-14 тижні вагітності. Були досліджені аномалії розвитку сіамських близнюків, пацієнту було рекомендовано генетичне консультування перед плануванням наступної вагітності.
Ключові слова: сіамські близнюки, торакоомфалопагі, аномалії розвитку.
References
Mehmet A. Osmanağaoğlu, Turhan Aran, Süleyman Güven, Cavit Kart, Özgür Özdemir, Hasan Bozkaya (2011). Thoracopagus Conjoined Twins: A Case Report. ISRN Obstet Gynecol 2011; 2011: 238360.
De Ugarte DA, Boechat MI, Shaw WW, Laks H, Williams H, Atkinson JB (2002). Parasitic omphalopagus complicated by omphalocele and congenital heart disease. J Pediatr Surg. 2002 Sep;37(9):1357-8.
Jeroen Smits, Christiaan Monden (2011). Twinning across the Developing World. PLoS One. 2011; 6(9): e25239.
Kalgutkar AD, Pethe V, Pandit SP, Karmarkar S, Deshmukh SS, Ramdwar S, Deodhar KP (1996). Blastopathies--symmetrical conjoined twins. Indian J Pathol Microbiol. 1996 Jul;39(3):233-6.
Ana Cristina Aoun Tannuri, Julio Americo Pereira Batatinha, Manoel Carlos Prieto Velhote, Uenis Tannuri (2013). Conjoined twins – twenty years' experience at a reference center in Brazil. Clinics (Sao Paulo). 2013 Mar; 68(3): 371–377.
Rachel E. Andrews, Robert W.M. Yates, Ian D Sullivan (2015). The management of conjoined twins: Cardiology assessment. Semin Pediatr Surg. 2015 Oct;24(5):217-20.
D. Serapinas, E. Butkeviciene, K. Daugelaite, A. Narbekovas, J. Juskevicius, A. Bartkeviciute, D. Bartkeviciene (2016). Conjoined twins after in-vitro fertilization. Eur J Obstet Gynecol, 2016
Mercan R, Oktem O, Salar Z, Nuhoglu A, Balaban B, Urman B (2011). Conjoined twins after intracytoplasmic sperm injection and transfer of day-3 embryos. Fertil Steril. 2011 Aug;96(2):e111-4.
Métneki J, Czeizel A (1987). Griseofulvin teratology. Lancet, 1987 May 2;1(8540):1042.
Wertelecki W (2010). Malformations in a chornobyl-impacted region. Pediatrics. 2010 Apr;125(4):e836-43
Lipitz S, Ravia J, Zolti M, Achiron R, Wolf Y, Kazanstein A, Goldenberg M, Seidman DS (1995). Sequential genetic events leading to conjoined twins in a monozygotic triplet pregnancy. Hum Reprod. 1995 Dec;10(12):3130-2.
Eva Pajkrt, Eric Jauniaux (2005). First-trimester diagnosis of conjoined twins. Prenat Diagn 2005; 25: 820–826.
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