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Abstract
CLINICAL AND LABORATORY-INSTRUMENTAL FEATURES OF MIXED HERPESVIRAL MENINGITES IN CHILDREN WHICH CAUSED BY COMBINATION OF HERPES SIMPLEX VIRUS AND CYTOMEGALOVIRUS Kirsanova T.A, Kuznetsov S.V. Kharkiv national medical university, Kharkiv, Ukraine Abstract. The children of pre-school and school age with the burdened premorbid background, the average physical and physiological neuropsychic development more often have mixed herpesviral meningitis, caused by the combination of the virus of herpes simplex with the cytomegalovirus, somewhat more frequent in spring and in summer. The clinical picture was characterized by the symptoms of intoxication, catarrhal, general cerebral, gepato- or gepatolienal syndromes. In the peripheral blood of patients more there are found lymphocytosis, increase of ESR, anemia; in the urine of half of patients there is detected protein, of third part – acetone; in the liquor there is moderate lymphocytic cytosis, decrease of level of sodium and calcium. On electrocardiogram of children there are revealed sinus arrhythmia and disturbances of repolarization processes. On the echoencephalogram of the overwhelming majority of patients it is recorded normotension. Keywords: children, virus meningitis, the virus of herpes simplex, cytomegalovirus, clinical picture. КЛІНІЧНІ ТА ЛАБОРАТОРНО-ІНСТРУМЕНТАЛЬНІ ОСОБЛИВОСТІ МІКСТ ГЕРПЕСВІРУСНИХ МЕНІНГІТІВ У ДІТЕЙ, ЩО ЗУМОВЛЕНІ ПОЄДНАННЯМ ВІРУСУ ПРОСТОГО ГЕРПЕСУ ТА ЦИТОМЕГАЛОВІРУСОМ Т.О. Кірсанова, С.В. Кузнєцов Харківський національний медичний університет, м. Харків, Україна Резюме. Мікст герпесвірусні менінгіти, що обумовлені поєднанням вірусу простого герпесу з цитомегаловірусом, частіше реєструються у дітей дошкільного та шкільного віку з обтяженим преморбідним фоном, середнього фізичного та фізіологічного нервово-психічного розвитку, декілька частіше весною та літом. Клінічна картина захворювання переважно вкладається у рамки середньотяжких форм та характеризується наявністю токсичного, катарального, загальномозкового, гепато- або гепатолієнального синдромів. У периферичній крові хворих частіше реєструється лімфоцитоз, збільшення ШОЄ, анемія; у сечі половини хворих виявляється білок, третини – ацетон; в лікворі – помірний лімфоцитарній цитоз, зниження кількісного вмісту натрію та кальцію. На ЕКГ у хворих дітей виявляється синусова аритмія та порушення процесів реполяризації. На ЕхоЕГ у переважній більшості хворих реєструється нормотензія. Ключові слова: діти, вірусний менінгіт, вірус простого герпесу, цитомегаловірус, клінічна картина. КЛИНИЧЕСКИЕ И ЛАБОРАТОРНО-ИНСТРУМЕНТАЛЬНЫЕ ОСОБЕННОСТИ МИКСТ ГЕРПЕСВИРУСНЫХ МЕНИНГИТОВ У ДЕТЕЙ, КОТОРЫЕ ОБУСЛОВЛЕНЫ СОЧЕТАНИЕМ ВИРУСА ПРОСТОГО ГЕРПЕСА И ЦИТОМЕГАЛОВИРУСА Т.А. Кирсанова, С.В. Кузнецов Харьковский национальный медицинский университет, г. Харьков, Украина Резюме. Микст герпесвирусные менингиты, обусловленные сочетанием вируса простого герпеса с цитомегаловирусом, чаще регистрируются у детей дошкольного и школьного возраста с отягощенным преморбидным фоном, среднего физического и физиологического нервно-психического развития, несколько чаще весной и летом. Клиническая картина заболевания преимущественно укладывается в рамки среднетяжелых форм и характеризуется наличием токсичного, катарального, общемозгового, гепато- или гепатолиенального синдромов. В периферической крови больных чаще регистрируется лимфоцитоз, увеличение СОЭ, анемия; в моче половины больных выявляется белок, трети - ацетон; в ликворе - умеренный лимфоцитарный цитоз, снижение количественного содержания натрия и кальция. На ЭКГ у больных детей выявляется синусовая аритмия и нарушения процессов реполяризации. На ЭхоЭГ у подавляющего большинства больных регистрируется нормотензия. Ключевые слова: дети, вирусный менингит, вирус простого герпеса, цитомегаловирус, клиническая картина.
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