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Abstract
Bilovol А.N., Tkachenko S.G.
The study involved an assessment of medical history data and clinical features of psoriasis in 230 patients, of whom 182 suffered from isolated dermatosis and 48 from psoriasis with comorbid hypertension. The psoriasis group with concomitant arterial hypertension was found to have a significantly higher frequency of stressful situations (81% of cases as compared to 62%) and infectious diseases were registered less frequently (6% vs. 28%). Relapses of psoriasis in this group occurred more often, out-of-season type was observed more than 1.5 times more frequently and seasonal type of dermatosis was registered 2 times less often. Moreover, rapid dissemination of rash during exacerbations in patients with psoriasis with concomitant hypertension was observed two times as frequently (28% of cases vs. 16%), and cases of slow and gradual spread were more rare.
Key words: psoriasis, arterial hypertension, history taking, clinical characteristics.
Клінічні особливості протікання псоріазу, асоційованого з артеріальною гіпертензією
Біловол А.М., Ткаченко С.Г.
Проаналізовано анамнестичні дані та клінічні особливості протікання псоріазу у 230 хворих, серед яких 182 пацієнти страждали на ізольований дерматоз, та 48 – на псоріаз, асоційований з артеріальною гіпертензією. В групі псоріаз з супутньою артеріальною гіпертензією виявлена значно більша частота стресових ситуацій (81 % випадків проти 62 % ) та рідше реєструються інфекційні захворювання (6 % проти 28 %). Рецидиви псоріазу в цій групі відбувалися частіше, більш ніж у 1,5 рази частіше відмічався позасезонний і в 2 рази рідше – сезонний тип перебігу дерматозу. Також у хворих на псоріаз з супутньою гіпертензією в 2 рази частіше відмічалася швидка дисемінація уражень шкіри при загостреннях (28 % випадків проти 16 %) та були більш рідкими випадки повільного і поступового їх розповсюдження.
Ключові слова: псоріаз, артеріальна гіпертензія, анамнез, клінічна характеристика.
Клинические особенности течения псориаза, ассоциированного с артериальной гипертензией
Беловол А.Н., Ткаченко С.Г.
Проанализированы анамнестические данные и клинические особенности течения псориаза у 230 больных, среди которых 182 пациента страдали изолированным дерматозом, и 48 – псориазом, ассоциированным с артериальной гипертензией. В группе псориаза с сопутствующей артериальной гипертензией выявлена значительно большая частота стрессовых ситуаций (81 % случав против 62 % ) и реже регистрируются инфекционные заболевания (6 % против 28 %). Рецидивы псориаза в этой группе возникали чаще, более чем в 1,5 раза чаще отмечался внесезонный и в 2 раза реже – сезонный тип течения дерматоза. Также у больных псориазом с сопутствующей гипертензией в 2 раза чаще отмечалась быстрая диссеминация высыпаний при обострениях (28 % случаев против 16 %) и были более редкими случаи медленного и постепенного распространения.
Ключевые слова: псориаз, артериальная гипертензия, анамнез, клиническая характеристика.
References
Yeung, H. et al. (2013). Psoriasis Severity and the Prevalence of Major Medical ComorbidityA Population-Based Study. JAMA Dermatol., 149 (10), 1173-1179
Mahe, E. et al. (2013). Childhood-onset psoriasis: association with future cardiovascular and metabolic comorbidities. British Journal of Dermatology, 169, 889–895.
Choi, H.K. et al. (2007). Risk of myocardial infarction in patients with psoriatic arthritis. Arthr.Reum., 56 ( 9), 799.
Ahlehoff, O. et al. (2012). Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish Nationwide Cohort Study. Eur Heart J., 33(16), 2054-2064.
Wang, Y. et al. (2012). Chronic skin-specific inflammation promotes vascular inflammation and thrombosis. J Invest Dermatol. 132(8). 2067-2075.
Dowlatshahi, E.A. et al. (2013). Markers of Systemic Inflammation in Psoriasis. A Systematic Review and Meta-analysis. The British Journal of Dermatology. 169 (2). 266-282.
Kungurov, N.V., Philimonkova, N.N., Topiychkanova, E.P. (2013). Systemnaya vospalytelnaya reactsia i yavleniya dyslipidemii pri psoriase [Systemic inflammatory reaction and phenomenons of dyslipidemia in psoriasis]. Fundamental research. 9 (1). 188-194.
Shtoda, U.M., Slyesarenko, N.A., Rodionova, T. I. et al. (2014). Nekotoryye aspekty obshchnosti patogeneza sakharnogo diabeta 2 tipa i psoriaza [Some aspects of the common pathogenesis of type 2 diabetes and psoriasis]. Fundamental research. 4(3). 647-654.
Perlamutrov, Yu. N., Mikryukov, A.V. (2013). Kliniko-laboratornyye kharakteristiki psoriaza, assotsiirovannogo s gormonal'no-metabolicheskimi narusheniyami [Clinico-laboratory characteristics of psoriasis associated with hormonal-metabolic disorders] Russian Journal of Skin and Sexually Transmitted Diseases, 5, 46-50.
Slesarenko, N.A., Utts, S.R., Shtoda, Yu. M., Platonova, A.N. (2013). Endotelial'naya disfunktsiya pri psoriaze i sakharnom diabete 2-go tipa v usloviyakh komorbidnosti [Endothelial dysfunction in psoriasis and type 2 diabetes mellitus in conditions of comorbidity]. Saratov Journal of Medical Scientific Research. 9(3), 590-595.
Barile, S. et al. (2006). Vascular endothelial growth factor gene polymorphisms increase the risk to develop psoriasis. Exp. Dermatol.,15(5),368-376.
Sosnovskaya, O.A. (2012). Narusheniya endotelial'noy funktsii sosudov u bol'nykh psoriazom [Violations of endothelial function of blood vessels in patients with psoriasis]. University clinic, 8 (1), 17-20.
Berehova, A.A. (2015). Stan sympato-adrenalovoyi systemy u khvorykh na psoriaz z riznym stupenem tyazhkosti klinichnoho perebihu [State of the sympathoadrenal system in patients with psoriasis with varying degrees of severity of clinical course ]. Dermatology and venereology, 1(67), 20-26.
Belovol, А.N., Tkachenko, S.G. Izuchenyye komorbidnosti psoriasa s kardiometabolicheskyh narushenij [Study of comorbidity of psoriasis and cardiometabolic disorders ] (2014). / Modern problems of dermatovenereology, cosmetology and management of public health. V. 11.-Kharkiv, 35-42.
Belovol, A.N., Tkachenko, S.G., Kondrashova, V.B. (2011). The study of comorbidity of psoriasis and metabolic syndrome. 20 Congress of the EADV, Lisbon (Portugal), 219.
Kimball, A.B. et al (2008). National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening. J. Am. Acad. Dermatol. 58(6),1031-1042.
Cohen, A.D. et al.(2005). Drug exposure and psoriasis vulgaris: case–control and case–crossover studies. Acta Derm Venereol., 85, 299–303.
Antonov, D., Grozdev, I., Pehlivanov, G., Tsankov N. (2006). Psoriatic erythroderma associated with enalapril. Skinmed ., 5, 90–92.
Andrashko, U.V., Litvinenko, B.V. (2009). Sovryemenniye podhody k etapnoy naruzhnoy terapiyi pry psoriaze [Modern approaches to step-wise topical therapy for psoriasis]. Ukranian journal of dermatology, venereology, cosmetology, 1, 29-32.
Vocel, G. (2010). Strategiya lecheniya vulgarnogo psoriaza I psoriaticheskogo artrita [The strategy of treating vulgar psoriasis and psoriatic arthritis]. Dermatologist, 1 (01), 47-56
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