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Abstract
NEW APPROACHES TO THE TREATMENT OF PATIENTS WITH SEBORRHEIC DEERMATITIS
Bolotna L. A., Narozhna M. V., Sarian О. I.
The article presents results of complex treatment of 55 patients with seborrheic dermatitis (SD) at the age of 26-48 years. Patients with SD are divided into two groups, homogeneous by age, sex, clinical forms, severity, laboratory parameters. Patients of group 1 in the cold period of the year (November-March) were administered cholecalciferol (vitamin D
3) and synbiotic (combined probiotic) DermaPro in the background of complex traditional therapy. Patients of group 2 received only traditional treatment. Clinical remission and significant improvement were detected in group 1 patients (88.2%) more often compared with the similar result in group 2 patients (52.4%). Relapses of the disease were detected in 23.6% of patients in group 1 and 50.0% in patients in group 2 within one year. The appointment of patients with SD cholecalciferol and DermaPro led to an increase levels of 25(OH)D by 81.5% and cathelicidin LL-37 by 78.4%, normalization and improvement of gut microbiota in 88.2% of cases. The use of traditional therapy resulted in only normalization and improvement of intestinal biocenosis in 28.5% of patients.Key words: vitamin D3, probiotic, clinical and laboratory efficacy, treatment, seborrheic dermatitis.
НОВІ ПІДХОДИ ДО ЛІКУВАННЯ ХВОРИХ НА СЕБОРЕЙНИЙ ДЕРМАТИТ
Болотна Л. А., Нарожна М. В., Саріан О. І.У статті представлені результати комплексного лікування 55 хворих на себорейний дерматит у віці 26-48 років. Хворі на СД розділені на дві групи, однорідні за віком, статтю, клінічними формами, тяжкістю, лабораторними показниками. Хворим 1 групи в холодний період року (листопад-березень) призначали всередину холекальциферол (вітамін D3) і синбіотик (комбінований пробіотик) ДермаПро на тлі комплексної традиційної терапії. Пацієнти 2 групи отримували тільки традиційне лікування. Клінічна ремісія і значне поліпшення частіше визначено у хворих 1 групи (88,2%) у порівнянні з аналогічним результатом у хворих 2 групи (52,4%). Рецидиви хвороби протягом одного року виявлено у 23,6% пацієнтів 1 групи і 50,0% хворих 2 групи. Призначення хворим СД холекальциферола і ДермаПро зумовило підвищення в крові рівня 25(ОН)D на 81,5% і кателіцидину LL-37 на 78,4%, нормалізацію і поліпшення показників товстокишечної мікрофлори у 88,2% випадків. Використання засобів традиційної терапії призвело лише до нормалізації і поліпшення показників біоценозу кишечника у 28,5% хворих.
Ключевые слова: витамін D3, пробіотик, клініко-лабораторна ефективність, лікування, себорейний дерматит.
НОВЫЕ ПОДХОДЫ К ЛЕЧЕНИЮ БОЛЬНЫХ СЕБОРЕЙНЫМ ДЕРМАТИТОМ
Болотная Л. А., Нарожная М. В., Сариан Е. И.
В статье представлены результаты комплексного лечения 55 больных себорейным дерматитом в возрасте 26-48 лет. Больные СД разделены на две группы, однородные по возрасту, полу, клиническим формам, тяжести, лабораторным показателям. Больным 1 группы в холодный период года (ноябрь-март) назначали внутрь холекальциферол (витамин D3) и синбиотик (комбинированный пробиотик) ДермаПро на фоне комплексной традиционной терапии. Пациенты 2 группы получали только традиционное лечение. Клиническая ремиссия и значительное улучшение чаще определены у больных 1 группы (88,2 %) по сравнению с аналогичным результатом у больных 2 группы (52,4 %). Рецидивы болезни в течение одного года выявлены у 23,6 % пациентов 1 группы и 50,0 % больных 2 группы. Назначение больным СД холекальциферола и ДермаПро обусловило повышение в крови уровня 25(ОН)D на 81,5 % и кателицидина LL-37 на 78,4 %, нормализацию и улучшение показателей толстокишечной микрофлоры в 88,2 % случаев. Применение средств традиционной терапии привело только к нормализации и улучшению показателей биоценоза кишечника у 28,5 % пациентов.
Ключевые слова: витамин D3, пробиотик, клинико-лабораторная эффективность, лечение, себорейный дерматит.
References
Kornishova, V. G., Mogileva, Ye. Yu. (2012). Seboreynyy dermatit (obzor) [Seborrheic dermatitis (review)]. Probl med mikol, no 3, pp. 3-11.
Paulino, L. C. (2017). New perspectives on dandruff and seborrheic dermatitis: lessons we learned from bacterial and fungal skin microbiota. Eur J Dermatol, 27(S1), 4-7.
Dessinioti, C., Katsambas, A. (2013). Seborrheic dermatitis: etiology, risk factors, and treatments: facts and controversies. Clinics in Dermatol, 31(6), 343-351.
Bakardzhiev, I., Argirov A. (2017). New Insights into the etiopathogenesis of seborrheic dermatitis. Clin Res Dermatol Open Access, 4(1), 1-5.
Clark, G. W., Pope, C. M., Jaboori, K. A. (2015). Diagnosis and treatment of seborrheic dermatitis. Am Fam Physician, 91(3), 185-190.
Chowdhry, S., Gupta, S., D’souza, P. (2017). Topical antifungals used for treatment of seborrheic dermatitis. J Bacteriol Mycol Open Access, 4(1). doi: 10.15406/jbmoa.2017.04.00076.
Baysal, V., Yildirim, M., Ozcanli, C., Ceyhan, A. M. (2004). Itraconazole in the treatment of seborrheic dermatitis: a new treatment modality. Int J Dermatol, 43(1), 63-66.
Holick, M. F., Binkley, N. C., Bischoff-Ferrari, H. A., Gordon, C.M., Hanley, D. A., Heaney, R. P., … Weaver, C. M. (2011). Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab, 96(7), 1911-1930.
Bekirova, E. Yu. (2013). Vliyaniye vitamina D na sintez tsitokinov indutsirovannymi mononuklearnymi leykotsitami u patsiyentov psoriazom s D-defitsitom [Influence of vitamin D on the synthesis of cytokines induced by mononuclear leukocytes in patients with psoriasis with D-deficiency]. Tavrich mediko-biol vestn, vol. 16, pp. 22-24.
Bell, D.S. (2011). Protean manifestations of vitamin deficiency, part 2: dificiency and its association with autoimmune disease, cancer, infection, astma, dermopathies, insulin resistans, and type 2 diabetes. South Med S, 104, (5), 335-339.
Polat, M., Uzun, Ö. (2014). Vitamin D in dermatology. Open Access Dermatology, 2(1), 9.
Narozhnaya, M. V. (2017). Obosnovaniye primeneniya vitamina D v lechenii seboreynogo dermatita [Substantiation of the use of vitamin D in the treatment of seborrheic dermatitis]. Dermatovenerol Kosmetol, 3(3), pp. 292-299.
Garland, C. F., French, C. B., Baggerly, L. L., Heaney, R. N. (2011). Vitamin D supplement doses and serum 25-hydroxyvitamin D in the range associated with cancer prevention. Anticancer Res, 31(2), 607-611.
Pigarova, Ye. A., Pleshcheva, A. V., Dzeranova, L. K. (2015). Vliyaniye vitamina D na immunnuyu sistemu [The effect of vitamin D on the immune system]. Immunol, vol. 36, no 1, pp. 62-66.
Maylyan, E. A., Reznichenko N. A., Maylyan, D. E. (2017). Ekstraskeletnyye effekty vitamina D: rol' v patogeneze allergicheskikh zabolevaniy [Extracellet effects of vitamin D: a role in the pathogenesis of allergic diseases]. Nauchnyye vedomosti Seriya Meditsina. Farmatsiya, no 5(254), pp. 22-33.
Roider, E., Ruzicka, T., Schauber, J. (2013). Vitamin D, the cutaneous barrier, antimicrobial peptides and allergies: Is there a link? Allergy Asthma Immunol Res, 5(3), 119-128.
Butel, M. J. (2014). Probiotics, gut microbiota and health. Med Mal Infect 44(1), 1-8.
Sanchez, B., Delgado, S., Blanco-Mıguez, A., Lourenco, A., Gueimonde, M., Margolles, A. (2017). Probiotics, gut microbiota, and their influence on host health and disease. Mol Nutr Food Res, 61(1), 17-32.
Vaughn, A. R, Notay, M., Clark, A. K., Sivamani, R. K. (2017). Skin-gut axis: The relationship between intestinal bacteria and skin health. World J Dermatol, 6(4), 52-58.
Ly, N. P., Litonjua, A., Gold, D. R., Celedón, J. C. (2011). Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity? J Allergy Clin Immunol, 127(5), 1087-1094.
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