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Abstract
Abstract.
MENSTRUAL CYCLE-RELATED CHANGES IN BLOOD SERUM TESTOSTERONE AND ESTRADIOL LEVELS AND THEIR RATIO STABILITY IN YOUNG HEALTHY FEMALES
Popova L. ., Vasylyeva L., Tkachenko A., Polikarpova H., Kökbaş U., Tuli A2, Kayrin L., Nakonechna A.
The role of testosterone in females has not been fully elucidated. Studies usually involved postmenopausal women. Literature data on age-related changes of testosterone levels are contradictory. The application of sex hormones and their combination in medical practice increases the importance of study of the menstrual cycle fluctuations in testosterone, populational variability of testosterone and estradiol levels and their ratio in healthy females to prevent the excessive doses of sex steroids and provide the using of optimal their doses in different phases of menstrual cycle during treatment.The objective of our research was to evaluate testosterone and estradiol levels, their interrelation and their ratio in different stages of menstrual cycle in young healthy women. Twenty-two young Ukrainian females aged 18 to 22 years were enrolled in this study. Testosterone and estradiol levels in blood serum were determined by Estradiol ELISA andTestosterone ELISA kits (Italy). Both estradiol and testosterone levels depended on menstrual cycle phases. The highest testosterone level was revealed in ovulation. No correlation between blood serum testosterone and estradiol levels was found in all menstrual cycle phases. Differences in testosterone and estradiol levels between Ukrainian women and some other populations of women were noted, indicating that such differences must be taken into account when treating women of different populations. Testosterone/estradiol ratio was not changed during menstrual cycle. Because of the constancy of the ratio of testosterone to estradiol during menstrual cycle and the age-related change in that ratio, this must be taken into account in the treatment of elderly women in order to create a testosterone-estradiol ratio that is characteristic of young women.
Key words: Testosterone, estradiol, menstrual cycle phases, women.
Резюме
НЕ ТІЛЬКИ РІВЕНЬ ЕСТРАДІОЛУ, АЛЕ Й ТЕСТОСТЕРОНУ ЗАЛЕЖИТЬ ВІД ФАЗИ МЕНСТРУАЛЬНОГО ЦИКЛУ
Попова Л.Д., Васильєва І.М., Ткаченко А.С., Полікарпова Г.В., Кокбаш У., Туллі А., Кайрін Л., Наконечна О.А.
Роль тестостерону у жінок висвітлена недостатньо. У дослідженнях зазвичай беруть участь жінки в постменопаузі. Дані літератури про вікові зміни рівня тестостерону суперечливі. Застосування статевих гормонів та їх комбінації в медичній практиці підвищує важливість вивчення коливань тестостерону в менструальному циклі, популяційної мінливості рівнів тестостерону та естрадіолу та їх співвідношення у здорових жінок для запобігання надмірних доз статевих стероїдів та забезпечення використання їх оптимальних доз в різні фази менструального циклу під час лікування. Метою нашого дослідження було оцінити рівень тестостерону та естрадіолу, їх взаємозв'язок та їх співвідношення у різні фази менструального циклу у молодих здорових жінок. До дослідження були залучені двадцять дві молоді жінки віком від 18 до 22 років. Рівні тестостерону та естрадіолу в сироватці крові визначали імуноферментним методом. Рівні естрадіолу і тестостерону залежали від фаз менструального циклу. Найвищий рівень тестостерону виявлений під час овуляції. Не було виявлено кореляції між рівнем тестостерону і естрадіолу в сироватці крові у всіх фазах менструального циклу. Відмічено відмінності в рівнях тестостерону та естрадіолу між українськими жінками та жінками деяких інших популяцій, що свідчить про те, що такі відмінності слід враховувати при лікуванні жінок різних популяцій. Співвідношення тестостерону до естрадіолу не змінювалось під час менструального циклу. Зважаючи на сталість співвідношення тестостерону до естрадіолу під час менструального циклу та зміну цього співвідношення з віком, необхідно враховувати це при лікуванні жінок похилого віку з метою створення співвідношення тестостерону до естрадіолу, характерного для молодих жінок.
Ключові слова: тестостерон, естрадіол, фази менструального циклу, жінки.
Резюме
НЕ ТОЛЬКО УРОВЕНЬ ЭСТРАДИОЛА, НО И ТЕСТОСТЕРОНА ЗАВИСИТ ОТ ФАЗЫ МЕНСТРУАЛЬНОГО ЦИКЛА
Попова Л.Д., Васильева И.М., Ткаченко А.С., Поликарпова А.В., Кокбаш У., Тулли А., Кайрин Л., Наконечная О.А.
Роль тестостерона у женщин освещена недостаточно. В исследованиях обычно участвуют женщины в постменопаузе. Данные литературы о возрастных изменениях уровня тестостерона противоречивы.Применение половых гормонов и их комбинации в медицинской практике повышает важность изучения колебаний тестостерона в менструальном цикле, популяционной изменчивости уровней тестостерона и эстрадиола и их соотношений у здоровых женщин для предотвращения чрезмерных доз половых стероидов и обеспечения использования оптимальных доз в различные фазы менструального цикла во время лечения. Целью нашего исследования было оценить уровень тестостерона и эстрадиола, их взаимосвязь и их соотношение в разные фазы менструального цикла у молодых здоровых женщин. В исследование были включены двадцать две молодые женщины в возрасте от 18 до 22 лет. Уровни тестостерона и эстрадиола в сыворотке крови определяли иммуноферментным методом. Уровни эстрадиола и тестостерона зависели от фаз менструального цикла. Самый высокий уровень тестостерона обнаружен во время овуляции. Не было обнаружено корреляции между уровнем тестостерона и эстрадиола в сыворотке крови во всех фазах менструального цикла. Были отмечены различия в уровнях тестостерона и эстрадиола между украинскими женщинами и некоторыми другими популяциями женщин, что указывает на то, что такие различия необходимо учитывать при лечении женщин разных популяций. Соотношение тестостерона / эстрадиола не менялось во время менструального цикла. Учитывая постоянство соотношения тестостерона к эстрадиолу во время менструального цикла и изменение этого соотношения с возрастом, необходимо учитывать это при лечении пожилых женщин с целью создания соотношение тестостерона к эстрадиолу, характерного для молодых женщин.
Ключевые слова: тестостерон, эстрадиол, фазы менструального цикла, женщины.
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