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Abstract
THE ROLE OF TRACE ELEMENT SELENIUM IN CARDIOVASCULAR DISEASE DEVELOPMENT (review)
Zhuravlyova L.V., Filonenko M.V.
Balanced levels of trace element selenium are of high importance for many of the body’s regulatory and metabolic functions. Reduction in selenium supply in humans can lead to an increased risk of various pathologies, including cardiovascular diseases. This article considers the contemporary opinions on the role of selenium in physiology and pathophysiology of the cardiovascular system. A particular attention is payed to the effects of selenium deficiency on the development of acute coronary syndrome, including myocardial damage after ischemia/reperfusion and postinfarction remodeling of the left ventricle. Also, the intrinsic properties of selenium for inhibition of apoptosis are highlighted.
Keywords: selenium, selenoproteins, cardiovascular disease.
Резюме
РОЛЬ МІКРОЕЛЕМЕНТУ СЕЛЕНУ В РОЗВИТКУ СЕРЦЕВО-СУДИННИХ ЗАХВОРЮВАНЬ
Журавльова Л.В., Філоненко М.В.
Збалансовані рівні мікроелементу селену мають велике значення для багатьох регуляторних та метаболічних функцій організму. Зниження надходження селену в організм людини може призвести до підвищеного ризику розвитку різних патологій, включаючи серцево-судинні захворювання. В статті розглянуто сучасні погляди на роль селену в забезпеченні функціонування серцево-судинної системи. Особливої уваги приділено впливу дефіциту селену на розвиток гострого коронарного синдрому, включаючи ураження міокарда після ішемії / реперфузії та постінфарктного ремоделювання лівого шлуночка. Також виствітлено аспекти внутрішніх властивостей селену щодо інгібування апоптозу.
Ключові слова: селен, селенопротеїни, серцево-судинні захворювання.
Резюме
РОЛЬ МИКРОЭЛЕМЕНТА СЕЛЕНА В РАЗВИТИИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙ
Журавлева Л.В., Филоненко М.В.
Сбалансированный уровень микроэлемента селена имеет большое значение для многих регуляторных и метаболических функций организма. Снижение поступления селена в организм может привести к увеличению риска развития различных патологий, в том числе сердечно-сосудистых заболеваний. В данной статье рассмотрены современные взгляды на роль селена в обеспечении функционирования сердечно-сосудистой системы. Особое внимание уделено влиянию дефицита селена на развитие острого коронарного синдрома, включая повреждение миокарда после ишемии / реперфузии и постинфарктного ремоделирования левого желудочка. Также освещены аспекты внутренних свойств селена по ингибированию апоптоза.
Ключевые слова: селен, селенопротеины, сердечно-сосудистые заболевания.
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