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Abstract
FEATURES OF THE CLINICAL COURSE OF ROTAVIRUS INFECTION IN CHILDREN INFECTED WITH HERPES VIRUSES AND THEIR BLOOD INTERLEUKIN REACTIONS
Sliepchenko M.Yu.
Background. The widespread prevalence of intestinal infections of rotavirus etiology, the economic damage caused by it and the difficulties of treating patients cause the medical and social significance of this pathology. Along with this, a herpes virus infection and its negative effect on the immune response of the human body is a pressing problem. The purpose of the study is to identify the characteristics of presentation and the course of rotavirus infection in children infected with herpes viruses, and to establish the characteristics of the reaction of interleukins in their blood. Subjects and Methods. 38 children aged one to three years with moderate and severe forms of intestinal infection rotavirus etiology, who received appropriate treatment were examined. The children were divided into two groups: Group 1 included 18 children who did not have a background infection and Group 2 comprised 20 patients with acute rotavirus infection who were infected with herpes viruses. Along with the generally accepted clinical and laboratory examination, the levels of interleukins 1β, 4, TNFα in the blood serum in the time course of the disease were determined by an ELISA method for all children. Results. Assessment of clinical and immunological parameters of rotavirus infection in children showed that infection with viruses of the herpes group contributed to a less severity of symptoms of the disease at the initial stage, but longer persistence, which was probably due to insufficient reaction of proinflammatory interleukins in blood in the acute period at relatively high levels during the course of the disease.
Keywords: clinic, children, cytokines, herpes and rotavirus infections.
Резюме.
ОСОБЛИВОСТІ КЛІНІЧНОГО ПЕРЕБІГУ РОТАВІРУСНОЇ ІНФЕКЦІЇ У ДІТЕЙ, ІНФІКОВАНИХ ГЕРПЕСВІРУСАМИ, І РЕАКЦІЇ ІНТЕРЛЕЙКІНІВ ЇХ КРОВІ
Слєпченко М.Ю.
Вступ. Широка розповсюдженість кишкових інфекцій ротавірусної етіології, спричинені нею економічні збитки і труднощі терапії хворих обумовлюють медичне і соціальне значення зазначеної патології. Поряд з цим, актуальною проблемою є герпесвірусна інфекція і її негативний вплив на імунну відповідь організму людини. Мета дослідження полягає у виявленні особливостей клінічної картини і перебігу ротавірусної інфекції у дітей, інфікованих герпесвирусами, а також, встановлення особливостей реакції інтерлейкінів їх крові. Суб’єкт та методи. Для реалізації мети нами було обстежено 38 дітей у віці одного - трьох років, хворих на середньотяжкі і тяжкі форми кишкової інфекції ротавірусної етіології, з приводу якої вони отримували відповідне лікування. Діти були розділені на дві групи: перша група - 18 дітей не мали фонового інфікування і друга група- 20 хворих, що переносили РВИ на тлі інфікування їх різними герпесвирусами. Поряд із загальноприйнятим клініко-лабораторним обстеженням усім дітям визначалися рівні інтерлейкінів 1β, 4, ФНО в сироватці крові в динаміці хвороби імуноферментним методом. Результати. При аналізі клініко-імунологічних параметрів ротавірусної інфекції у дітей встановлено, що інфікування вірусами групи герпес сприяє меншій виразності симптомів хвороби на початковому етапі, але більш тривалого їх збереження, що, ймовірно, обумовлено недостатньо вираженою реакцією прозапальних інтерлейкінів крові дітей в гострий період, і збереженням їх на відносно високому рівні протягом хвороби.
Ключові слова: діти, герпес- і ротавірусна інфекції, клініка, цитокіни.
Резюме.
ОСОБЕННОСТИ КЛИНИЧЕСКОГО ТЕЧЕНИЯ РОТАВИРУСНОЙ ИНФЕКЦИИ У ДЕТЕЙ, ИНФИЦИРОВАННЫХ ГЕРПЕСВИРУСАМИ, И РЕАКЦИИ ИНТЕРЛЕЙКИНОВ ИХ КРОВИ.
Слепченко М.Ю.
Вступление. Широкая распространенность кишечных инфекций ротавирусной этиологии, наносимый ею экономический ущерб и трудности терапии больных обуславливают медицинское и социальное значение указанной патологии. Наряду с этим, актуальной проблемой является герпесвирусная инфекция и ее негативное влияние на имунный ответ организма человека. Цель исследования заключается в выявлении особенностей клинической картины и течения ротавирусной инфекции у детей, инфицированных герпесвирусами, а также, установлении особенностей реакции интерлейкинов их крови. Субъект и методы. Для реализации цели нами было обследовано 38 детей в возрасте одного - трех лет, больных среднетяжелыми и тяжелыми формами кишечной инфекции ротавирусной этиологии, по поводу которой они получали соответствующее лечение. Дети были разделены на две группы: первая группа - 18 детей не имели фонового инфицирования и вторая группа - 20 пациентов, переносили РВИ на фоне инфицирования их различными герпесвирусами. Наряду с общепринятым клинико-лабораторным обследованием всем детям определялись уровни интерлейкинов 1β, 4, ФНОα в сыворотке крови в динамике болезни иммуноферментным методом. Результаты. При анализе клинико-иммунологических параметров ротавирусной инфекции у детей установлено, что инфицирование вирусами группы герпес способствует меньшей выраженности симптомов болезни на начальном этапе, но более длительному их сохранению, что, вероятно, обусловлено недостаточно выраженной реакцией провоспалительных интерлейкинов крови детей в острый период, и сохранением их на относительно высоких цифрах в течении болезни.
Ключевые слова: дети, герпес- и ротавирусная инфекции, клиника, цитокины.
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