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Abstract
DENTAL STATUS IN BREAST CANCER PATIENTS DURING THE IV CYCLE OF CHEMOTHERAPY APPLYING PREVENTIVE MEASURES Sukhina I.S. Kharkiv national medical university, Kharkiv, Ukraine Abstract. The study was focused on the impact of the preventive hygiene measures (PHM) on the manifestation of the side effects of cytostatic treatment in the oral cavity based on the evaluation of the patients’ survey data and the exploration of the patients’ oral mucosa status during the IV cycle of chemotherapy. All participants of the clinical study were divided into two groups. These groups of breast cancer (BC) patients with T1N0M0 – T2N1M0 stage included 26 and 63 patients. The patients’ age ranged from 32 to 76 years in both groups. Group 1 patients only brushed their teeth 1 time/day with any toothpaste, or didn’t use any hygiene products at all. During the entire cycle of chemotherapy, Group 2 patients complied with a set of PHM, developed by us. Fourth cycle of chemotherapy in BC patients significantly affects the condition of the oral cavity – 88.4 % of Group 1 patients showed signs of the side effects of cytostatic treatment in the oral cavity. The set of PHM was used in the comparison group during the IV cycle of chemotherapy to significantly reduce the incidence of pathological manifestations in the oral cavity in Group 2 patients to 66.7 %. The developed set of PHM contributes to a reliable decrease of only cheilitis incidence, which indicates the necessity for further improvement of methods of oral hygiene in BC patients during chemotherapy. Keywords: breast cancer, oral cavity, mucositis, chemotherapy, preventive hygiene measures СТОМАТОЛОГІЧНИЙСТАТУСУ ХВОРИХна рак молочної залозиПІД ЧАСПРОВЕДЕННЯIVЦИКЛУполіхіміотерапії НАТЛІпрофілактичних заходів Сухіна І.С. Харківський національний медичний університет, м. Харків, Україна Резюме. Проведено вивчення впливу профілактичних гігієнічних заходів (ПГЗ) на прояв побічної дії цитостатичного лікування в порожнині рота на підставі оцінювання даних опитування пацієнток і вивчення стану слизової оболонки ротової порожнини пацієнток під час проведення ІV циклу поліхіміотерапії (ПХТ). Усі онкологічні хворі, які брали участь у клінічному дослідженні, були розділені на дві групи. До груп входило 26 та 63 пацієнтки, хворих на рак молочної залози (РМЗ) T1N0M0 – T2N1M0 стадій. В обох групах вік пацієнток коливався в діапазоні від 32 до 76 років. Пацієнтки групи 1 лише чистили зуби 1 раз/добу будь-якими зубними пастами або зовсім не застосовували гігієнічні засоби. Пацієнтки групи 2 під час проведення всього циклу ПХТ дотримувалися розробленого нами комплексу ПГЗ. Четвертий цикл ПХТ у хворих на РМЗ суттєво впливає на стан органів ротової порожнини – у 88,4 % пацієнток групи 1 виявлено ознаки побічної дії цитостатичного лікування в порожнині рота. Розроблений нами та застосований в групі порівняння комплекс профілактичних гігієнічних заходів під час IV циклу ПХТ вірогідно знижує частоту патологічних проявів в порожнині рота у пацієнток групи 2 до 66,7 %. Застосування розробленого комплексу ПГЗ сприяє достовірному зниженню тільки проявів хейліту, що свідчить про необхідність подальшого вдосконалення методів гігієни у хворих на РМЗ під час проведення ПХТ. Ключові слова: рак молочної залози, ротова порожнина, мукозит, хіміотерапія, профілактичні гігієнічні заходи/ СТОМАТОЛОГИЧЕСКИЙ СТАТУС У БОЛЬНЫХ РАКОМ МОЛОЧНОЙ ЖЕЛЕЗЫ ВО ВРЕМЯ ПРОВЕДЕНИЯ IV ЦИКЛА ПОЛИХИМИОТЕРАПИИ НА ФОНЕ ПРОФИЛАКТИЧЕСКИХ МЕРОПРИЯТИЙ Сухина И.С. Харьковский национальный медицинский университет, г. Харьков, Украина Резюме. Проведено изучение влияния профилактических гигиенических мероприятий (ПГМ) на проявление побочного действия цитостатического лечения в полости рта на основании оценки данных опроса пациенток и изучения состояния слизистой оболочки ротовой полости пациенток при проведении IV цикла полихимиотерапии (ПХТ). Все онкологические больные, которые принимали участие в клиническом исследовании, были разделены на две группы. В группы входило 26 и 63 пациентки, больных раком молочной железы (РМЖ) T1N0M0 – T2N1M0 стадий. В обеих группах возраст пациентов колебался в диапазоне от 32 до 76 лет. Пациентки группы 1 только чистили зубы 1 раз/сутки любыми зубными пастами или вообще не применяли гигиенические средства. Пациентки группы 2 во время проведения всего цикла ПХТ придерживались разработанного нами комплекса ПГМ. Четвертый цикл ПХТ у больных РМЖ существенно влияет на состояние органов полости рта – у 88,4 % пациенток группы 1 обнаружены признаки побочного действия цитостатического лечения в полости рта. Разработанный нами и использованный в группе сравнения комплекс ПГМ при проведении IV цикла ПХТ достоверно снижает частоту патологических проявлений в полости рта у пациенток группы 2 до 66,7 %. Применение разработанного комплекса ПГМ способствует достоверному снижению только проявлений хейлита, что свидетельствует о необходимости дальнейшего совершенствования методов гигиены у больных РМЖ при проведении ПХТ. Ключевые слова: рак молочной железы, ротовая полость, мукозит, химиотерапия, профилактические гигиенические мероприятия
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