VARIANTS OF HYPERLIPIDEMIA IN CHILDREN WITH INSULIN RESISTANCE
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Keywords

Hyperlipidemia, insulin resistance, obesity, pediatrics

Abstract

Obesity in adults and children is characterized by epidemiological prevalence with a tendency to increase. Purpose of the study- to analyze the lipid profile in overweight children, depending on the presence of insulin resistance. 247 overweight and obese children aged 2 to 18 were examined, including 160 boys and 87 girls. Obesity was diagnosed if the BMI exceeded 97 percentile, according to gender and age. Assessment of the lipid profile included measurements of total cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein. To evaluate the parameters of the lipid profile, we used the National Cholesterol Education Program (NCEP) according to the latest edition (2006). We analyzed lipid values depending on the presence or absence of insulin resistance. BMI was also evaluated according to Z-BMI. Insulin resistance was detected in 69.9% of children. Hyperlipidemia was detected in 24.9% of children and dyslipidemia in 83% of the children examined. A change was found in all indicators of the lipid profile, depending on the presence of insulin resistance. A significant increase in Z-BMI was revealed depending on the presence of insulin resistance. Conclusions: Most overweight children have insulin resistance and dyslipidemia; the type of dyslipidemia in children with obesity directly depends on the presence of insulin resistance.

https://doi.org/10.35339/ic.7.1.23-25
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References

WHO fact sheet № 311, jan.2015. Available from: URL: http://www.who.int/mediacentre/factsheets/fs311/en/

Styne, D.M., Arslanian, S.A., Connor, E.L., Farooqi, I.S., Murad, M.H., Silverstein, J.H., Yanovski, J.A. (2017). Pediatric Obesity—Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab, 102(3), 709–757, doi: 10.1210/jc.2016-2573.

Zelins'ka, N., Rudenko, N. (2017). Dytjacha endokrynologija v Ukrai'ni: Statystychni pokaznyky za pidsumkamy 2016 roku ta i'h dynamika. [Child endocrinology in Ukraine: statistical indicators for pidums 2016 rock and ix dynamics.] Ukrai'ns'kyj zhurnal dytjachoi' endokrynologii'. 2 (22) pp. 5—17.

Cook, S., Kavey, R. E. W. (2011). Dyslipidemia and Pediatric Obesity. Pediatr Clin North Am, 58(6), 1363–1373. doi:10.1016/j.pcl.2011.09.003.

Berenson, G. S. (2009). Cardiovascular risk begins in childhood: a time for action. The American Journal of Preventive Medicine, 37 (1), S1–S2.

Lewis, G. F., Carpentier, A., Adeli, K., Giacca, A. (2002). Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocrine Reviews, 23(2), 201–229

Al-Hamad, D., Raman V. (2017). Metabolic syndrome in children and adolescents. Transl Pediatr, 6(4), 397–407. doi: 10.21037/tp.2017.10.02

Nakaz MOZ Ukraїni №254 vіd 27.04.2006 «Pro zatverdzhennya protokolіv nadannya medichnoї dopomogi dіtyam za specіal'nіstyu «Dityacha endokrinologіya»

WHO BMI-for-age (5-19 years), 2007. Available from: URL: https://www.who.int/growthref/who2007_bmi_for_age/en/

Jolliffe, C. J., Janssen, I. (2006). Distribution of Lipoproteins by Age and Gender in Adolescents. Circulation, 114 (10), 1056-1062.

Peplies, J., Jiménez-Pavón, D., Savva, S.C., Buck, C., Günther, K., Fraterman, A., … Ahrens, W.(2014). Percentiles of fasting serum insulin, glucose, HbA1c

and HOMA-IR in pre-pubertal normal weight Europeanchildren from the IDEFICS cohort. International Journal of Obesity, 38 (39–47). doi:10.1038/ijo.2014.134

Kostovski, M., Simeonovski, V., Mironska, K., Tasic, V., Gucev, Z. (2018). Metabolic Profiles in Obese Children and Adolescents with Insulin Resistance. Open Access Maced J Med Sci, 6(3): 511–518. doi: 10.3889/oamjms. 2018.097

Atabek, ME., Pirgon, O., Kurtoglu, S. (2007). Assessment of abnormal glucose homeostasis and insulin resistance in Turkish obese children and adolescents. Diabetes Obes Metab, 9(3):304-10.

Romualdo, MC., Nóbrega, FJ., Escrivão, MA. (2014). Insulin resistance in obese children and adolescents. J Pediatr (Rio J), 90(6):600-7.

Ling, JC., Mohamed, MN., Jalaludin, MY., Rampal, S., Zaharan, NL., Mohamed, Z. (2016). Determinants of High Fasting Insulin and Insulin Resistance Among Overweight/Obese Adolescents. Sci Rep, 6():36270.

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