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Abstract
CERTAIN CRITERIA OF RENAL AFFECTION IN CASE OF COPD. Ospanova T., Semydotska Zh., Veremeyenko O., Avdeyeva O. Kharkiv national medical university, Kharkiv, Ukraine Abstract. Chronic pulmonary problems belong to the group of leading diseases in modern society. Often the severity of the course and prognosis of chronic pathology of lungs are determined by extrapulmonary manifestations of the disease. Nephrological aspects of lung pathology are poorly studied. In this clinical research, we have examined 27 patients with COPD of the II-nd and III-rd stages of pulmonary insufficiency of the II-nd – III-rd degree. There were 20 (74%) males and 7 (26%) females. The average age of patients was 53 ± 3,7 years. The severity of clinical picture in patients with COPD is increased while the progress of the pathological process occurs. The association of nephropathy at the early stages of its development does not worsen the clinical course. The diagnosis of microalbuminuria is the early marker of renal involvement in the pathological process. The development of combined acidosis is distinctive for patients with COPD. Kidneys are actively involved in the compensation of these disorders by increasing the excretion of titrating acids, and at later stages the increased ammoniogenesis becomes evident. Keywords: chronic obstructive pulmonary disease, nephropathy, microalbuminuria. ВИЗНАЧЕНІ КРИТЕРІЇ УРАЖЕННЯ НИРОК ПРИ ХОЗЛ Оспанова Т., Семідоцька Ж., Веремеєнко О., Авдєєва О. Харківський національний медичний університет, м. Харків, Україна Резюме. В сучасному суспільстві хронічні захворювання легенів входять до групи провідних захворювань. Дуже часто важкість перебігу та прогноз хронічної патології легенів визначаються екстрапульмональними проявами хвороби. Нефрологічні аспекти патології легень є недостатньо вивченими. У проведеному дослідженні нами було обстежено 27 хворих на ХОЗЛ ІІ, ІІІ стадії з легеневою недостатністю ІІ-ІІІ ступеню. З них було 20 (74%) чоловіків та 7 (26%) жінок. Середній вік хворих складав 53±3,7 роки. Важкість клінічної картини у хворих на ХОЗЛ наростає по мірі прогресування патологічного процесу. Приєднання нефропатії на початкових етапах її розвитку клінічно не погіршує перебіг. Ранніми маркерами включення нирок у патологічний процес є визначення мікроальбумінурії. Для хворих на ХОЗЛ характерним є розвиток змішаного ацидозу. Нирки приймають активну участь у компенсації цих порушень шляхом підвищення екскреції кислот, що титрують, а на більш пізніх стадіях підвищується амоніогенез. Ключеві слова: хронічне обструктивне захворювання легенів, нефропатія, мікроальбумінурія. ОПРЕДЕЛЕННЫЕ КРИТЕРИИ ПОРАЖЕНИЯ ПОЧЕК ПРИ ХОЗЛ Оспанова Т., Семидоцкая Ж., Веремеенко О., Авдеева О. Харьковский национальный медицинский университет, г. Харьков, Украина Резюме. В современном обществе хронические заболевания легких входят в группу ведущих заболеваний. Очень часто тяжесть течения и прогноз хронической патологии легких определяются экстрапульмональными проявлениями болезни. Однако, нефрологические аспекты патологии легких остаются недостаточно изученными. В проведенном исследовании нами было обследовано 27 больных ХОЗЛ II, III стадий с легочной недостаточностью II-III степени . Из них было 20 (74% ) мужчин и 7 ( 26% ) женщин. Средний возраст больных составлял 53 ± 3,7 года. Тяжесть клинической картины у больных ХОЗЛ нарастает по мере прогрессирования патологического процесса. Присоединение нефропатии на начальных этапах ее развития клинически не ухудшает течение. Ранними маркерами включения почек в патологический процесс является нарастание микроальбуминурии. Также для больных ХОЗЛ характерно развитие смешанного ацидоза. Почки принимают активное участие в компенсации этих нарушений путем повышения экскреции титруемых кислот, а на более поздних стадиях повышается амониогенез. Ключевые слова: хроническое обструктивное заболевание легких, нефропатия, микроальбуминурия.
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