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Abstract
Background. Patients with comorbid pathology occupy leading positions in the practice of a doctor of any specialty especially in patients with HIV. Reproductive system is known to be the gateway for viruses. This fact could explain the severity of changes developing in the female reproductive system infected with HIV, in particular in the endometrium.
The purpose of this study was to assess morphological changes in the endometrium caused by the combined effects of HIV infection and chronic alcoholism.
Materials and methods: The study included sectional material taken from 60 women of reproductive age (20-40 years). They were all divided into two groups. The first group (30 people) consisted of HIV-positive individuals who, according to a survey of relatives and according to an autopsy (the main symptom is the presence of alcoholic cirrhosis of the liver), alcohol abuse was confirmed. The following parameters were determined: the average diameter of the endometrial glands (proliferative type), the minimum diameter of the endometrial glands (proliferative type), the maximum diameter of the endometrial glands (proliferative type), wall thickness (proliferative type), the relative volume of the epithelium (proliferative type), the average diameter of the glands (secretory type), the minimum diameter of the glands (secretory type), the maximum diameter of the glands (secretory type), the relative volume of the epithelium (secretory type), the thickness of the epithelium.
Results. the average diameter of the endometrial glands (proliferative type) decreased from 51.71 ± 2.90 x 10-6 m in the comparison group to 39.42 ± 2.35 x 10-6 m in the HIV-infected group, which was 23.77%. The minimum diameter of the endometrial glands (proliferative type) reduced from 32.47 ± 1.83 x10-6 m to 27.13 ± 1.73x10-6 m (16.45%), the maximum diameter from 72.14 ± 2.21 x10-6 m to 63.84 ± 3.29 x10-6 m (11.5%). the relative volume of the epithelium (proliferative type) decreased by 5.41% (from 54.43 ± 1.79% in the study group to 49.02 ± 2.65% in the control group). The thickness of the uterine wall was also significantly reduced from 15.18 ± 1.60 x10-6 m to 14.52 ± 1.19 x10-6 m, which was 4.35%. The maximum volume of glands (secretory type) changed from 127.98 ± 2.10 x10-6 m to 97.18 ± 3.12 x10-6 m (24%). Changes by 3.6% were also observed when examining the wall thickness (from 13.02 ± 1.36 x10-6 m to 12.55 ± 1.68 x10-6 m).
Conclusion. The study evaluated features of endometrial restructuring in alcohol-abusing HIV-infected women.
References
Green, A. (2017). The HIV response in Ukraine: at a crossroads. Lancet (London, England), 390(10092), 347-348. https://doi.org/10.1016/S0140-6736(17)31915-3
Lytvynenko, M., Shkolnikov, V., Bocharova, T., Sychova, L. & Gargin, V. (2017). Peculiaritiesof proliferative activity of cervical squamous cancer in hiv infection. Georgian medical news, (270), 10-15.
Pelchen-Matthews, A., Ryom, L., Borges, A. H., Edwards, S., Duvivier, C., Stephan, C.,Sambatakou, H., Maciejewska, K., Portu, J. J., Weber, J., Degen, O., Calmy, A., Reikvam, D. H., Jevtovic, D., Wiese, L., Smidt, J., Smiatacz, T., Hassoun, G., Kuznetsova, A., Clotet, B., … EuroSIDA study (2018). Aging and the evolution of comorbidities among HIV-positive individuals in a European cohort. AIDS (London, England), 32(16), 2405-2416. https://doi.org/10.1097/QAD.0000000000001967
Zoufaly, A., Cozzi-Lepri, A., Reekie, J., Kirk, O., Lundgren, J., Reiss, P., Jevtovic, D., Machala, L.,Zangerle, R., Mocroft, A., Van Lunzen, J., & EuroSIDA in EuroCoord (2014). Immuno-virological discordance and the risk of non-AIDS and AIDS events in a large observational cohort of HIV-patients in Europe. PloS one, 9(1), e87160. https://doi.org/10.1371/journal.pone.0087160
Wahlstrom, J. T., & Dobs, A. S. (2000). Acute and long-term effects of AIDS and injection druguse on gonadal function. Journal of acquired immune deficiency syndromes (1999), 25 Suppl 1, S27S36. https://doi.org/10.1097/00042560-200010001-00005
Allen, N. E., Beral, V., Casabonne, D., Kan, S. W., Reeves, G. K., Brown, A., Green, J., & MillionWomen Study Collaborators (2009). Moderate alcohol intake and cancer incidence in women. Journal of the National Cancer Institute, 101(5), 296-305. https://doi.org/10.1093/jnci/djn514
Cao, Y., Willett, W. C., Rimm, E. B., Stampfer, M. J., & Giovannucci, E. L. (2015). Light tomoderate intake of alcohol, drinking patterns, and risk of cancer: results from two prospective US cohort studies. BMJ (Clinical research ed.), 351, h4238. https://doi.org/10.1136/bmj.h4238
Hahn, J. A., & Samet, J. H. (2010). Alcohol and HIV disease progression: weighing the evidence.Current HIV/AIDS reports, 7(4), 226-233. https://doi.org/10.1007/s11904-010-0060-6
Armstrong, M. L., LaPlante, A. M., Altice, F. L., Copenhaver, M., & Molina, P. E. (2015). AdvancingBehavioral HIV Prevention: Adapting an Evidence-Based Intervention for People Living with HIV and Alcohol Use Disorders. AIDS research and treatment, 2015, 879052. https://doi.org/10.1155/2015/879052
Theall, K. P., Amedee, A., Clark, R. A., Dumestre, J., & Kissinger, P. (2008). Alcohol consumptionand HIV-1 vaginal RNA shedding among women. Journal of studies on alcohol and drugs, 69(3), 454458. https://doi.org/10.15288/jsad.2008.69.454
Gargin, V., Radutny, R., Titova, G., Bibik, D., Kirichenko, A., & Bazhenov, O. (2020). Applicationof the computer vision system for evaluation of pathomorphological images. Paper presented at the 2020 IEEE 40th International Conference on Electronics and Nanotechnology, ELNANO 2020 - Proceedings, 469-473. doi: 10.1109/ELNANO50318.2020.9088898.
Lytvynenko M. (2020). Features of endometrial restructuring in HIV infection. Inter collegas,7(4), 200-204. doi: 10.35339/ic.7.4.200-204.
Peuchmaur, M., Emilie, D., Vazeux, R., Pons, J. C., Delfraissy, J. F., Lemaigre, G., & Galanaud, P. (1989). HIV-associated endometritis. AIDS (London, England), 3(4), 239-241. https://doi.org/10.1097/00002030-198904000-00008
Mor, G. (2013). The female reproductive tract and HIV: biological, social and epidemiologicalaspects. American journal of reproductive immunology (New York, N.Y. : 1989), 69 Suppl 1, 1. https://doi.org/10.1111/aji.12082
Shepherd, L., Borges, A., Ledergerber, B., Domingo, P., Castagna, A., Rockstroh, J., Knysz, B., Tomazic, J., Karpov, I., Kirk, O., Lundgren, J., Mocroft, A. & EuroSIDA in EuroCOORD (2016). Infection-related and -unrelated malignancies, HIV and the aging population. HIV medicine, 17(8), 590600. https://doi.org/10.1111/hiv.12359
Roan, N. R. & Jakobsen, M. R. (2016). Friend or Foe: Innate Sensing of HIV in the Female Reproductive Tract. Current HIV/AIDS reports, 13(1), 53-63. https://doi.org/10.1007/s11904-016-0305-0
Sanderson, P. A., Critchley, H. O., Williams, A. R., Arends, M. J. & Saunders, P. T. (2017). Newconcepts for an old problem: the diagnosis of endometrial hyperplasia. Human reproduction update, 23(2), 232-254. https://doi.org/10.1093/humupd/dmw042
Mahovlic, V., Ovanin-Rakic, A., Skopljanac-Macina, L., Barisic, A., Rajhvajn, S., Juric, D., Projic,I. S., Ilic-Forko, J., Babic, D., Skrablin-Kucic, S., & Bozikov, J. (2010). Digital morphometry of cytologic aspirate endometrial samples. Collegium antropologicum, 34(1), 45-51.
Popova, L., Vasylyeva, L., Tkachenko, A., Polikarpova, H., Kokbas, U., Tuli, A, Kayrin, L., & Nakonechna, A. (2019) Menstrual cycle-related changes in blood serum testosterone and estradiol levels and their ratio stability in young healthy females. Inter collegas, 6(3), 155-161.
Bull, L., Tittle, V., Rashid, T., & Nwokolo, N. (2018). HIV and the menopause: A review. Postreproductive health, 24(1), 19-25. https://doi.org/10.1177/2053369117748794
Silverberg S. G. (2007). The endometrium. Archives of pathology & laboratory medicine, 131(3), 372-382. https://doi.org/10.1043/1543-2165(2007)131[372:TE]2.0.CO;2
Trimble, C. L., Method, M., Leitao, M., Lu, K., Ioffe, O., Hampton, M., Higgins, R., Zaino, R., Mutter, G. L., & Society of Gynecologic Oncology Clinical Practice Committee (2012). Management of endometrial precancers. Obstetrics and gynecology, 120(5), 1160-1175. https://doi.org/10.1097/aog.0b013e31826bb121
Lax S. (2011). Vorlauferlasionen des Endometriumkarzinoms: Diagnostik und Molekularpathologie[Precursor lesions of endometrial carcinoma: diagnostic approach and molecular pathology]. Der Pathologe, 32, Suppl 2, 255-264. https://doi.org/10.1007/s00292-011-1514-3
Sobczuk, K., & Sobczuk, A. (2017). New classification system of endometrial hyperplasia WHO2014 and its clinical implications. Przeglad menopauzalny = Menopause review, 16(3), 107-111. https://doi.org/10.5114/pm.2017.70589
Tam, T., Harkins, G., Caldwell, T., Zaino, R., & Hazard, D. (2013). Endometrial dye instillation: a novel approach to histopathologic evaluation of morcellated hysterectomy specimens. Journal of minimally invasive gynecology, 20(5), 667-671. https://doi.org/10.1016/j.jmig.2013.04.009
Kafka, J. K., Sheth, P. M., Nazli, A., Osborne, B. J., Kovacs, C., Kaul, R., & Kaushic, C. (2012). Endometrial epithelial cell response to semen from HIV-infected men during different stages of infection is distinct and can drive HIV-1-long terminal repeat. AIDS (London, England), 26(1), 27-36. https://doi.org/10.1097/QAD.0b013e32834e57b2
Reekie, J., Kowalska, J. D., Karpov, I., Rockstroh, J., Karlsson, A., Rakhmanova, A., Horban, A.,Kirk, O., Lundgren, J. D., Mocroft, A., & EuroSIDA in EuroCoord (2012). Regional differences in AIDS and non-AIDS related mortality in HIV-positive individuals across Europe and Argentina: the EuroSIDA study. PloS one, 7(7), e41673. https://doi.org/10.1371/journal.pone.0041673
Edi-Osagie, E. C., Seif, M. W., Aplin, J. D., Jones, C. J., Wilson, G., & Lieberman, B. A. (2004). Characterizing the endometrium in unexplained and tubal factor infertility: a multiparametric investigation. Fertility and sterility, 82(5), 1379-1389. https://doi.org/10.1016/j.fertnstert.2004.04.046
Sivridis, E., & Giatromanolaki, A. (2011). The pathogenesis of endometrial carcinomas atmenopause: facts and figures. Journal of clinical pathology, 64(7), 553-560. https://doi.org/10.1136/jcp.2010.085951
Litta, P., Agnello, A., & Azzena, A. (1992). HPV genital infections and contraception. Clinical andexperimental obstetrics & gynecology, 19(2), 136-138.
Lytvynenko, M., Bocharova, T., Zhelezniakova, N., Narbutova, T., & Gargin, V. (2017). Cervicaltransformation in alcohol abuse patients. Georgian medical news, (271), 12-17.
Hyriavenko, N., Lyndin, M., Sikora, K., Piddubnyi, A., Karpenko, L., Kravtsova, O., Hyriavenko, D.,Diachenko, O., Sikora, V., & Romaniuk, A. (2019). Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects. Journal of pathology and translational medicine, 53(4), 236-243. https://doi.org/10.4132/jptm.2019.03.21
Klyuchko, K. O., & Gargin, V. V. (2020). Influence of neoadjuvant chemoradiotherapy for locallyadvanced cervical cancer. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 48(288), 406-409.
Gu, Z., Zhu, P., Luo, H., Zhu, X., Zhang, G., & Wu, S. (1995). A morphometric study on theendometrial activity of women before and after one year with LNG-IUD in situ. Contraception, 52(1), 57-61. https://doi.org/10.1016/0010-7824(95)00125-t
Fernandes, A. T., da Rocha, N. P., Avvad, E., Grinsztejn, B. J., Russomano, F., Tristao, A.,Quintana, M., Perez, M. A., Conceicao-Silva, F., & Bonecini-Almeida, M. (2013). Balance of apoptotic and anti-apoptotic marker and perforin granule release in squamous intraepithelial lesions. HIV infection leads to a decrease in perforin degranulation. Experimental and molecular pathology, 95(2), 166-173. https://doi.org/10.1016/j.yexmp.2013.06.006
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