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Abstract
Background. The study of features of comorbid pathology in patients with epilepsy is of particular interest due to the high prevalence of this pathology and a significant impact on the quality of life of patients and their social adaptation.
Aim. The aim of the research was to detect versatile cognitive impairments and affective disorders in epilepsy, and to study the results of cognitive training and psychoeducation.
Materials and methods. The theoretical analysis of modern scientific researches in the field of cognitive and affective impairments during epilepsy was carried out. We studied the features of clinical and psychopathological manifestations in patients, suffering from epilepsy. The study covered 146patients (85 men and 61 women) who were in inpatient care. The following psychodiagnostic techniques were used: the MOCA test, the Toronto Cognitive Assessment (TorCA), the MiniMult test, the Münsterberg test, the quality of life scale, the Hamilton scale of depression and anxiety.
Results. This publication offers the results of a study of cognitive and affective disorders the quality of life in patients who suffer from epilepsy and the results of online cognitive training and psychoeducation. We found cognitive decline in 88% of patients with epilepsy and improvement of cognitive functions by methods of non-pharmacological correction.
Conclusions. Affective and cognitive disorders significantly affects the quality of life of patients, their ability to work and socialization. The conducted research showed that compared to the control group of healthy persons, patients with epilepsy showed improvement in their cognitive decline, anxiety and depressive disorders. Cognitive online training appeared to be effective for the patients with epilepsy.
References
Sen, A., Capelli, V., & Husain, M. (2018). Cognition and dementia in older patients with epilepsy. Brain, 141(6), 1592–1608. doi: 10.1093/brain/awy022
Helmstaedter, С. (2013). The impact of epilepsy cognitive function. J Neurol Neurosurg Psychiatry, 84, 5-15. doi: 10.1136/jnnp-2013-306103.14
Martsenkovskiy I. A., & Martsenkovskaya, I. I. (2015). Rasstroystva psikhiki i povedeniya pri epilepsiyakh: klinicheskaya tipologiya i terapevticheskie strategii [Mental and behavioral disorders in epilepsy: clinical typology and therapeutic strategies]. NeuroNEWS, 8, 21-33.
Gaitatzis, A., Trimble, M. R., & Sander, J. W. (2004). The psychiatric comorbidity of epilepsy. Acta Neurol Scand, 110(4), 207-220. doi: 10.1111/j.1600-0404.2004.00324.x
Gandy, M., Karin, E., Fogliati, V. J., McDonald, S., Titov, N., & Dear, B. F. (2016). A Feasibility Trial of an Internet-Delivered and Transdiagnostic Cognitive Behavioral Therapy Treatment Program for Anxiety, Depression, and Disability Among Adults With Epilepsy. Epilepsia, 57(11), 1887–1896. doi: 10.1111/epi.13569
Mula, M., & Trimble, M. R. (2009). Antiepileptic drug-induced cognitive adverse effects: potential mechanisms and contributing factors. CNS Drugs, 23(2), 121–137. doi: 10.2165/00023210-200923020-00003
Dodrill, C. В. (1986). Correlates of generalized tonic–clonic seizures with intellectual, neuropsychological, emotional and social function in patients with epilepsy. Epilepsia, 27(4), 399-411. doi: 10.1111/j.1528-1157.1986.tb03559.x
Aldenkamp, A. P., & Bodde, N. (2005). Behaviour, cognition and epilepsy. Acta Neurol Scand Suppl, 112(s182), 19-25. doi: 10.1111/j.1600-0404.2005.00523.x
Millan, M. J., Agid, Y., Brune, M, Bullmore, E. T., Carter, C. S., Clayton, N. S., … & Young L. J. (2012). Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov, 11(2)2, 141-168. doi: 10.1038/nrd3628
Kanner, A. M., Wuu, J., Faught, E., Tatum, W. O. 4th, Fix, A., & French, J. A. (2003). A past psychiatric history may be a risk factor for topiramate-related psychiatric and cognitive adverse events. Epilepsy Behav, 4(5), 548–552. doi: 10.1016/j.yebeh.2003.07.007
Unterberger, I., Zamarian, L., Prieschl, M., Bergmann, M., Walser, G., Luef, G., … & Delazer, M. (2018). Risky Decision Making in Juvenile Myoclonic Epilepsy. Front Neurol, 9, 195. doi: 10.3389/fneur.2018.00195
Osler, M., Mortensen, E. L., Christensen, K., & Christensen, G. T. (2018). A bidirectional association between cognitive ability in young adulthood and epilepsy: a population-based cohort study. Int J Epidemiol, 47(4), 1151-1158. doi: 10.1093/ije/dyy018
Strelnikova, I.N., & Polyakova, A.V. (2012). Struktura depressivnykh rasstroystv u bol'nykh epilepsiey [The structure of depressive disorders in patients with epilepsy]. Ukrajnskij visnyk psyhonevrologij, 20(3), 226.
Holmes, G. L. (2015). Cognitive impairment in epilepsy: the role of network abnormalities. Epileptic Disord, 17(2), 101-116. doi: 10.1684/epd.2015.0739
Wilson, R. S., Scherr, P. A., Schneider, J. A., Tang, Y., & Bennett, D. A. (2007). Relation of cognitive activity to risk of developing Alzheimer disease. Neurology, 69(20), 1911–1920. doi: 10.1212/01.wnl.0000271087.67782.cb
Kolb, B., & Gibb, R. (2008). Principles of neuroplasticity and behavior. In: D. Stuss, G. Winocur, I. Robertson. Cognitive neurorehabilitation: Evidence and Application. Cambridge University Press, 6–21. doi: 10.1017/CBO9781316529898.003
Naumenkо, А. А., Gromova, D. О., & Preobrazhenkaya, I. S. (2017). Kognitivnyy trening i reabilitatsiya patsientov s kognitivnymi narusheniyami [Cognitive Training and Rehabilitation of Patients with Cognitive Impairments]. Doctor Ru, 11, 31-38.
Rodakowski, J., Saghafi, E., Butters, M. A., & Skidmore, E. R. (2015). Nonpharmacological interventions for adults with mild cognitive impairment and early stage dementia: An updated scoping review. Mol. Aspects Med, 43-44, 38-53. doi: 10.1016/j.mam.2015.06.003.
Matsuoka, H., Nakamura, M., Ohno, T., Shimabukuro, J., Suzuki, T., Numachi, Y., & Awata, S. (2005). The role of cognitive-motor function in precipitation and inhibition of epileptic seizures. Epilepsia, 46(Suppl 1), 17-20. doi: 10.1111/j.0013-9580.2005.461006.x
Pakpour, A. H., Gholami, M., Esmaeili, R., Naghibi, S. A., Updegraff, J. A., Molloy, G. J., & Dombrowski, S. U. (2015). A randomized controlled multimodal behavioral intervention trial for improving antiepileptic drug adherence. Epilepsy Behav, 52(Pt A), 133-142. doi: 10.1016/j.yebeh.2015.08.036.
Tan, S. Y., & Bruni, J. (1986). Cognitive-behavior therapy with adult patients with epilepsy: a controlled outcome study. Epilepsia, 27(3), 225-233. doi: 10.1111/j.1528-1157.1986.tb03533.x
Carson, N., Leach, L., & Murphy, K. J. (2018). A re-examination of Montreal Cognitive Assessment (MoCA) cutoff scores. Int J Geriatr Psychiatry, 33(2), 379-388. doi: 10.1002/gps.4756.
Ciesielska N, Sokołowski R, Mazur E, Podhorecka M, Polak-Szabela A, & Kędziora-Kornatowska K. (2016). Is the Montreal Cognitive Assessment (MoCA) test better suited than the Mini-Mental State Examination (MMSE) in mild cognitive impairment (MCI) detection among people aged over 60? Meta-analysis. Psychiatr Pol, 50(5), 1039-1052. doi: 10.12740/PP/45368.
Nasreddine, Z. S., Phillips, N. A., Bedirian, V., Charbonneau, S., Whitehead, V., Collin, I., … & Chertkow H. (2005). The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc, 53(4), 695-699. doi: 10.1111/j.1532-5415.2005.53221.x
Poythress, N. G., & Blaney, P. H. (1978). The validity of MMPI interpretations based on the Minimult and the FAM. J Pers Assess, 42(2), 143-147. doi: 10.1207/s15327752jpa4202_5
Obeid, S., Hallit, C. E., Haddad, C., Hany, Z., & Hallit, S. (2018). Validation of the Hamilton Depression Rating Scale (HDRS) and sociodemographic factors associated with Lebanese depressed patients. Encephale, 44(5), 397-402. doi: 10.1016/j.encep.2017.10.010
Williams, J. B. (1988). A structured interview guide for the Hamilton Depression Rating Scale. Arch Gen Psychiatry, 45(8), 742-747. doi: 10.1001/archpsyc.1988.01800320058007
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