Keywords
How to Cite
Abstract
The review presents a modern view on the features of the course and treatment of acute pancreatitis, based on a cascade of pathophysiological mechanisms of this disease. A number of concepts of development and course of acute pancreatitis on the basis of randomized prospective and retrospective researches devoted to this problem are considered. Attention is paid to the mechanisms of development of organ failure in acute pancreatitis. In accordance with the above, the main positions of treatment measures for acute pancreatitis, which are based on the principles of tactics "step-up approach" were highlighted. Among them, attention is focused on the features of the conservative treatment program, minimally invasive surgical interventions, as well as the management of the postoperative period of patients. Minimally invasive surgical interventions perform the main tasks of surgical treatment in acute pancreatitis, but significantly reduce surgical trauma compared to "open" methods. Adequate management of the postoperative period of patients is carried out through the implementation of protocols "fast-track surgery".
References
Goodchild G., et al. (2009). Review Practical guide to the management of acute pancreatitis. Frontline Gastroenterology. 10. P. 292-299 DOI: 10.1136/flgastro-2018-101102
Gurusamy K.S., Belgaumkar A.P. et al. (2016). Interventions for necrotising pancreatitis (review). Cochrane Database of Systematic Reviews. Issue 4. Art. No.: CD011383. 83 p. DOI: 10.1002/14651858.CD011383.pub2.
Xiao AY, Tan ML, Wu LM, et al. (2016). Global incidence and mortality of pancreatic diseases: a systematic review, meta-analysis, and meta-regression of population-based cohort studies. Lancet Gastroenterol Hepatology. 1(1). P. 45–55. [PubMed: 28404111]
Pramod K. Garg, Vijay P. Singh. (2019). Organ Failure due to Systemic Injury in Acute Pancreatitis. Gastroenterology. Author manuscript. 156(7). P. 2008–2023. doi:10.1053/j.gastro.2018.12.041.
Leppaniemi Ari et al. (2019). 2019 WSES guideliners for the management of severe acute pancreatitis. World Journal of Emergency Surgery. 14:27. 20 p. https://doi.org/10.1186/s13017-019-0247-0
Working Group IAP/APA Acute Pancreatitis Guidelines. IAP/APA evidence-based guidelines for the management of acute pancreatitis. (2013). Pancreatology. 13. 15 p. http://dx.doi.org/10.1016/j.pan.2013.07.063
Peter A. Banks, Thomas L. Bollen et al. (2013). Classification of acute pancreatitis – 2012: revision of the Atlanta classification and definitions by international consensus. Pancreas. 62: P.102-111. DOI 10.1136/gutjnl-2012-302779
Hamada S, Masamune A, Kikuta K, et al. (2014). Nationwide epidemiological survey of acute pancreatitis in Japan. Pancreas. 43:1244–8. [PubMed: 25084001]
Kamal A, Sinha A, Hutfless SM, et al. (2017). Hospital admission volume does not impact the in-hospital mortality of acute pancreatitis. HPB (Oxford). 19:21–28. [PubMed: 27887788]
Padhan RK, Jain S, Agarwal S, et al. (2018). Primary and Secondary Organ Failures Cause Mortality Differentially in Acute Pancreatitis and Should be Distinguished. Pancreas. 47:302–307. [PubMed: 29401171].
Schepers NJ, Bakker OJ, Besselink MG, et al. (2018). Impact of characteristics of organ failure and infected necrosis on mortality in necrotising pancreatitis. 68(6): 1044-1051. doi: 10.1136/gutjnl-2017-314657.
de-Madaria E, Martinez J, Sempere L, et al. (2008). Cytokine genotypes in acute pancreatitis: association with etiology, severity, and cytokine levels in blood. Pancreas. 37:295–301. [PubMed: 18815552]
Bishehsari F, Sharma A, Stello K, et al. (2012). TNF-alpha gene (TNFA) variants increase risk for multi- organ dysfunction syndrome (MODS) in acute pancreatitis. Pancreatology. 12:113–8. [PubMed: 22487520].
Yang Z, Qi X, Wu Q, et al. (2012). Lack of association between TNF-alpha gene promoter polymorphisms and pancreatitis: a meta-analysis. 503:229–34. [PubMed: 22579868]
Reintam A, Parm P, Kitus R, Starkopf J, Kern H. (2008). Gastrointestinal failure score in critically ill patients: a prospective observational study. Crit Care 2008; 12(4):R90. doi: 10.1186/cc6958
Blaser A, Malbrain M, Starkopf J, Fruhwald Jakob S, De Waele J, Braun J, et al. (2012). Gastrointestinal function in intensive care patients: Terminology, definitions and management Recommendations of the ESICM Working Group on Abdominal Problems. Intensive Care Med. 38:384-94. doi: 10.1007/s00134-011-2459-y
Hiroyuki Funaoka 1, Tatsuo Kanda, Hiroshi Fujii (2010). Intestinal fatty acid-binding protein (I-FABP) as a new biomarker for intestinal diseases. Review. 2010 Feb;58(2):162-8. PMID: 20229815
Li H, Chen Y, Huo F, Wang Y, Zhang D. (2017). Association between acute gastrointestinal injury and biomarkers of intestinal barrier function in critically ill patients. ВМС Gastroenterology. 17:45 doi: 10.1186/sl2876-017-0603-z
Piton G, Belon F, Cypriani B, Regnard J,Puyraveau M, Manzon C, et al. (2013). Enterocyte damage in critically ill patients isassociated with shock condition and 28-day mortality. Crit Care Med. 2013 Sep; 41(9):2169-76. doi: 10.1097/CCM.0b013e31828c26b5
Uzun O, Turkmen S, Eryigit U et al. (2014). Can Intestinal Fatty Acid Binding Protein (I-FABP) Be A Marker in the Diagnosis of Abdominal Pathology? Turkish J Emerg Med. 14(3): 99-103. https://doi.org/10.5505/1304.7361.2014.15679; PMid:27355087 PMCid:PMC4909954
Voth, M., Lustenberger, T., Relja, B. et al. (2019). Is I-FABP not only a marker for the detection abdominal injury but also of hemorrhagic shock in severely injured trauma patients?. World J Emerg Surg 14, 49. https://doi.org/10.1186/s13017-019-0267-9
Darrivere L., Lapidus N., Colignon N. et al. (2018). Minimally invasive drainage in critically ill patients with severe necrotizing pancreatitis is associated with better outcomes: an observational study. Critical Care 2018. 22: 321. P. 299-321.
Sion M.K., Davis K.A. (2019). Step-up approach for the management of pancreatic necrosis: a review of the literature. Trauma Surgery & Acute Care Open. 4:e000308. 5 p. DOI:10.1136/tsaco-2019-000308
Yip H.C, Teoh A.Y.B. (2017). Endoscopic management of peripancreatic fluid collections. Gut and Liver, Published online. Sep 15; 11(5):604-611. https://doi.org/10.5009/gnl16178. May 12.
Haas B, Nathens A.B. (2010). Surgical indications in acute pancreatitis. Current Opinion in Critical Care. 16(2). Р. 153–158.
Hollemans A et al. (2016). Predicting success of catheter drainage in infected necrotizing pancreatitis. Ann Surg. 263(4). Р. 787–792. doi: 10.1097/SLA.0000000000001203.
Lichi K et al. (2016). Percutaneous Catheter Drainage in Infected Pancreatitis Necrosis: a Systematic Review. Indian J Surg. 78(3). Р. 221–228. doi: 10.1007/s12262-016-1495-9
Mittu J. M. (2014). Laparoscopic necrosectomy in acute necrotizing pancreatitis: Our experience. J Minim Access Surg. 10(3). Р. 126–131. doi: 10.4103/0972-9941.134875.
Dua M. M et al. (2015). Surgical Strategies for the Management of Necrotizing Pancreatitis. J Pancreas. 16(6). Р. 547–558. doi: 10.3748/wjg.v7.i4.476
Pedro S-V, Ana MA, Miguel C-B, António G, Maria FB, José GT. (2019). Murine Models of Acute Pancreatitis: A Critical Appraisal of Clinical Relevance. Int J Mol Sci. Jun; 20(11): 2794. Published online 2019 Jun 7. doi: 10.3390/ijms20112794 PMCID:PMC6600324
Porcu M, Solinas C, Migali C, Battaglia A et al. (2020). Immune Checkpoint Inhibitor-Induced Pancreatic Injury: Imaging Findings and Literature Review. Target Oncol. 2020 Feb; 15(1):25-35. doi: 10.1007/s11523-019-00694-w.PMID: 31925647 Review.
Rompianesi G, Hann A, Komolafe O, Pereira SP, Davidson BR, Gurusamy KS. (2017). Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis. Cochrane Database Syst Rev. 2017 Apr 21;4(4):CD012010. doi: 10.1002/14651858.CD012010.pub2.PMID: 28431198 Free PMC article. Review.
Sorrentino L, Chiara O, Mutignani M, et al. (2017). Combined totally mini-invasive approach in necrotizing pancreatitis: a case report and systematic literature review. World J Emerg Surg. 2017 Mar 16;12:16. doi: 10.1186/s13017-017-0126-5. eCollection 2017.PMID: 28331537
Tawfik K, Anas K, Mahmud M, Amir M, Wisam S. (2020). Bedside score predicting retained common bile duct stone in acute biliary pancreatitis. World J Clin Cases. 2020 Apr 26; 8(8): 1414–1423. Published online 2020 Apr 26. doi: 10.12998/wjcc.v8.i8.1414. PMCID:PMC7190963
Tonolini M, Di Pietro S. (2019). Diffusion-weighted MRI: new paradigm for the diagnosis of interstitial oedematous pancreatitis. Gland Surg. 2019 Apr;8(2):197-206. doi: 10.21037/gs.2018.12.08.PMID: 31183329 Free PMC article.
Weihao K, Yuanyuan H, Huarui B, Wenlong Z, Xingyu W. (2020). Diagnostic Value of Neutrophil-Lymphocyte Ratio for Predicting the Severity of Acute Pancreatitis: A Meta-Analysis. Dis Markers. 9731854. Published online 2020 Apr 27. doi: 10.1155/2020/9731854 PMCID: PMC7232731
Xu B, Bai B, Sha S, Yu P, et al. (2014). Interleukin-1β induces autophagy by affecting calcium homeostasis and trypsinogen activation in pancreatic acinar cells. Int J Clin Exp Pathol. 7:3620–3631.
Xuehua P, Baohai L, Xiaodan S, Shuangdi L et al. (2020). Picroside II Improves Severe Acute Pancreatitis-Induced Intestinal Barrier Injury by Inactivating Oxidative and Inflammatory TLR4-Dependent PI3K/AKT/NF-κB Signaling and Improving Gut Microbiota. Oxid Med Cell Longev. 2020: 3589497. Published online 2020 Apr12. doi: 10.1155/2020/3589497 PMCID: PMC7174951
Xu X, Ai F, Huang M. (2020). Deceased serum bilirubin and albumin levels in the assessment of severity and mortality in patients with acute pancreatitis. Int J Med Sci. 2020 Sep 23;17(17):2685-2695. doi: 10.7150/ijms.49606. eCollection 2020.PMID: 33162796 Free PMC article.
Yasmine HH, Ahmed OH, Abd-Elrahman MM, Joseph RA, Yasser AO. (2020). Adherence to the evidence-based guidelines in the management of acute biliary pancreatitis: A case series. Int J Surg Case Rep. 77: 906–914. Published online 2020 Dec. 2. doi: 10.1016/j.ijscr.2020.11.135 Correction in: Int J Surg Case Rep. 2021 Jan; 78: 417. PMCID:PMC7749290
Zhi Z, Yi-Xuan D, Yuan-Xu Q, Feng C, Fei L. (2021). A narrative review of acute pancreatitis and its diagnosis, pathogenetic mechanism, and management. Ann Transl Med. 2021 Jan; 9(1): 69. doi: 10.21037/atm-20-4802 PMCID:PMC7859757
Osuka A, Kusuki H, Matsuura H, Shimizu K et al. (2017). Acute intestinal damage following severe burn correlates with the development of multiple organ dysfunction syndrome: A prospective cohort study. 2017 Jun; 43(4):824-829. doi: 10.1016/j.burns.2016.10.015. Epub 2016 Dec 28.PMID: 28040364
Michał Ż, Georg B, Julia M. (2019). Risk Stratification and Early Conservative Treatment of Acute Pancreatitis. Visc Med. 2019 Apr; 35(2): 82–89. Published online 2019 Mar.25. doi: 10.1159/000497290 PMCID:PMC6514505
Lingling J, Hao C, Jun Y, Xin F et al. (2020). Combinatory antibiotic treatment protects against experimental acute pancreatitis by suppressing gut bacterial translocation to pancreas and inhibiting NLRP3 inflammasome pathway. Innate Immun. 2020 Jan; 26(1): 48–61. Published online 2019 Oct 15. doi: 10.1177/1753425919881502 PMCID: PMC6974879
Heckler M., Hackert Th., Hu K. et al. (2020). Severe acute pancreatitis: surgical indications and treatment (review). Langenbecks Arch. Surg. Sep.10. 2020. doi: 10.1007/s00423-020-01944-6. PMID: 32910276.
Amas Gómez L, Zubia Olaskoaga F. (2019). Results of the modification of an acute pancreatitis management protocol in Intensive Care medicine. Med Intensiva. 2019 Dec;43(9):546-555.
Adarsh PS, Moustafa MM, Simon RB. (2018). Acute pancreatitis: current perspectives on diagnosis and management. J Inflamm Res. 11: 77–85. Published online 2018 Mar 9. doi: 10.2147/JIR.S135751 PMCID: PMC5849938
Fonseca Sepúlveda EV, Guerrero-Lozano R. (2019). Acute pancreatitis and recurrent acute pancreatitis: an exploration of clinical and etiologic factors and outcomes. J Pediatr (Rio J). 2019 Nov - Dec; 95(6):713-719.
Linlin C, Huidan D, Hengmin C, Jing F. Et al. (2018). Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018 Jan 23; 9(6): 7204–7218. Published online 2017 Dec 14. doi: 10.18632/oncotarget.23208 PMCID:PMC5805548
Kehlet H., Wilmore D.W. (2005). Fast-track surgery. Section of Surgical Pathophysiology, The Juliane Marie Centre 4074, Rigshospitalet, DK-2100 Copenhagen, Denmark. P. 3-4. DOI:10.1002/bjs.4841
"Inter Collegas" is an open access journal: all articles are published in open access without an embargo period, under the terms of the CC BY-NC-SA (Creative Commons Attribution ‒ Noncommercial ‒ Share Alike) license; the content is available to all readers without registration from the moment of its publication. Electronic copies of the archive of journals are placed in the repositories of the KhNMU and V.I. Vernadsky National Library of Ukraine.
Copyright Agreement
1. This Agreement on the transfer of rights to use the work from the Co-authors to the publisher (hereinafter the Agreement) is concluded between all the Co-authors of the work, represented by the Corresponding Author, and Kharkiv National Medical University (hereinafter the University), represented by an authorized representative of the Editorial Board of scientific journals (hereinafter the Editorial Board).
2. This Agreement is an accession agreement within the meaning of clause 1 of Article 634 of the Civil Code of Ukraine: that is, a contract, "the terms of which are established by one of the parties in forms or other standard forms, which can be concluded only by joining the other party to the proposed contract as a whole. The other party cannot offer its terms of the contract." The party that established the terms of this contract is the University.
3. If there is more than one author, the authors choose the Corresponding Author, who communicates with the Editorial Board on his own behalf and on behalf of all Co-authors regarding the publication of a written work of a scientific nature (article or review, hereinafter referred to as the Work).
4. The contract begins from the moment of submission of the manuscript of the Work by the Corresponding Author to the Editorial Board, which confirms the following:
4.1. all Co-authors of the Work are familiar with and agree with its content, at all stages of reviewing and editing the manuscript and the existence of the published Work;
4.2. all Co-authors of the Work are familiar with and agree to the terms of this Agreement.
5. The published Work is in electronic form in public access on the websites of the University and any websites and electronic databases in which the Work is posted by the University and is available to readers under the terms of the "Creative Commons" license (Attribution NonCommercial Sharealike 4.0 International)" or more free licenses "Creative Commons 4.0".
6. The Corresponding Author transfers, and the University receives, the non-exclusive property right to use the Work by placing the latter on the University's websites for the entire term of copyright. The University participates in the creation of the final version of the Work by reviewing and editing the manuscript of the article or review provided to the Editorial Board by the Corresponding Author, translating the Work into any languages. For the participation of the University in the finalization of the Work, the Co-authors agree to pay the invoice issued to them by the University, if such payment is provided by the University. The size and procedure of such payment are not the subject of this contract.
7. The University has the right to reproduce the Work or its parts in electronic and printed forms, to make copies, permanent archival storage of the Work, distribution of the Work on the Internet, repositories, scientometric databases, commercial networks, including for monetary compensation from third parties.
8. The co-authors guarantee that the manuscript of the Work does not use works whose copyright belongs to third parties.
9. The authors of the Work guarantee that at the time of submission of the manuscript of the Work to the Editorial Board, the property rights to the Work belong only to them, neither in whole nor in part have they been transferred to anyone (not alienated), they are not the subject of a lien, litigation or claims by third parties.
10. The Work may not be posted on the University's website if it violates a person's right to the privacy of his personal and family life, harms public order and health.
11. The work may be withdrawn by the Editorial Board from the University websites, libraries and electronic databases where it was placed by the Editorial Board, in cases of detection of violations of the ethics of the authors and researchers, without any compensation for the losses of the Co-authors. At the time of submission of the manuscript to the Editorial Board and all stages of its editing and review, the manuscript must not have already been published or submitted to other editorial offices.
12. The right transferred under this Agreement extends to the territory of Ukraine and foreign countries.
13. The rights of Co-authors include the requirement to indicate their names on all copies of the Work or during any public use or public mention of the Work; the requirement to preserve the integrity of the Work; legal opposition to any distortion or other encroachment on the Work, which may harm the honor and reputation of the Co-authors.
14. Co-authors have the right to control their personal non-property rights by familiarizing themselves with the text (content) and form of the Work before its publication on the University's website, when transferring it to a printing company for reproduction or when using the Work in other ways.
15. The Co-authors, in addition to the property rights not transferred under this Agreement and taking into account the non-exclusive nature of the rights transferred under this Agreement, retain the property rights to finalize the Work and to use certain parts of the Work in other works created by the Co-authors.
16. The Co-authors are obliged to notify the Editorial Board of all errors in the Work, discovered by them independently after the publication of the Work, and to take all measures to eliminate such errors as soon as possible.
17. The University undertakes to indicate the names of the Co-authors on all copies of the Work during any public use of the Work. The list of Co-authors may be shortened according to the rules for the formation of bibliographic descriptions determined by the University or third parties.
18. The University undertakes not to violate the integrity of the Work, to agree with the Corresponding Author on all changes made to the Work during processing and editing.
19. In case of violation of their obligations under this Agreement, its parties bear the responsibility defined by this Agreement and the current legislation of Ukraine. All disputes under the Agreement are resolved through negotiations, and if the negotiations do not resolve the dispute – in the courts of the city of Kharkiv.
20. The parties are not responsible for the violation of their obligations under this Agreement, if it occurred through no fault of theirs. The party is considered innocent if it proves that it has taken all measures dependent on it for the proper fulfillment of the obligation.
21. The Co-authors are responsible for the truthfulness of the facts, quotes, references to legislative and regulatory acts, other official documentation, the scientific validity of the Work, all types of responsibility to third parties who have claimed their rights to the Work. The co-authors reimburse the University for all costs caused by claims of third parties for infringement of copyright and other rights to the Work, as well as additional material costs related to the elimination of identified defects.