pulmonary tuberculosis, insulin resistance, lipid disorders


Background. The problem of studying lipid metabolism in patients with tuberculosis is of interest to scientists around the world. The purpose of the study - to investigate lipid profile in pulmonary tuberculosis patients with concurrent insulin resistance.

Materials and methods. Forty-one patients with pulmonary tuberculosis were examined. Insulin resistance index (HOMA-IR), total cholesterol level (TC), triglycerides (TG) level, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, very-low-density lipoprotein (VLDL) cholesterol and atherogenic index (AI) were measured.

Results. Group 1 - 26 patients with tuberculosis and insulin resistance (HOMA-IR ˃ 2.7); Group 2 – 15 patients with tuberculosis without insulin resistance (HOMA-IR ˂ 2.7). Group 1 patients had severe course of TB with fever, severe fatigue and weakness, profuse sweating, weight loss, cough and shortness of breath. Median TC indices differed at significant level (p = 0.012): group 1 - 4.82 mmol/l, group 2 - 4.25 mmol/l. TG level was higher in group 1 patients - 1.32 mmol/l than in group 2 patients - 1.28 mmol/l. LDL cholesterol values were higher in group 1 patients - 3.2 mmol/l vs 2.5 mmol/l in group 2. The AI was higher in group1 (p = 0.005): 3.9 units against 2.8 units in group 2 patients.

Conclusions. Insulin resistance in pulmonary tuberculosis patients was associated with severe course of the disease, severe clinical manifestations and impaired external respiration. Pro-atherogenic disorders of lipid metabolism in pulmonary tuberculosis patients with concurrent insulin resistance can be considered as the degree of endogenous intoxication.


Dean, J.M., Lodhi, I.J. (2018). Structural and functional roles of ether lipids. Protein Cell., 9(2), 196-206. doi: 10.1007/s13238-017-0423-5.

de Carvalho, C.R., Caramujo, M.J.(2018). The Various Roles of Fatty Acids. Molecules., 23(10), 258-264. doi: 10.3390/molecules23102583.

Bernardi, S., Marcuzzi, A., Piscianz, E., Tommasini, A., Fabris, B. (2018). The Complex Interplay between Lipids, Immune System and Interleukins in Cardio-Metabolic Diseases., 19(12). doi: 10.3390/ijms19124058.

Traini, M., Kritharides, L. (2017). Lipids grease the wheels of the immune system. Curr Opin Lipidol., 28(6), 516-517. doi: 10.1097/MOL.0000000000000464.

Gebremicael, G., Amare, Y., Challa, F., et al. (2017). Lipid Profile in Tuberculosis Patients with and without Human Immunodeficiency Virus Infection. Int J Chronic Dis. doi:10.1155/2017/3843291

Gago, G., Diacovich, L., Gramajo, H. (2018). Lipid metabolism and its implication in mycobacteria-host interaction. Curr Opin Microbiol. 36-42. doi: 10.1016/j.mib.2017.11.020.

Vrieling, F., Ronacher, K., Kleynhans, L., van den Akker, E., Walzl, G., Ottenhoff, T., & Joosten, S. A. (2018). Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile. EBioMedicine, 32, 192–200.

Yaribeygi, H., Farrokhi, F.R., Butler, A.E., Sahebkar, A. (2019). Insulin resistance: Review of the underlying molecular mechanisms. J Cell Physiol., 234(6), 8152-8161. doi: 10.1002/jcp.27603.

Rivas, A.M., Nugent, K. (2021). Hyperglycemia, Insulin, and Insulin Resistance in Sepsis. Am J Med Sci., 361(3), 297-302. doi: 10.1016/j.amjms.2020.11.007.

Ormazabal, V., Nair, S., Elfeky, O. et al. (2018). Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol. 17, 122-130.

Shvets O.М. (2018) Study of lipid profile in patients with pulmonary tuberculosis on the background of insulin resistance [Shvec', O.M. (2018) Vyvchennja lipidnogo profilju u hvoryh na tuberkul'oz legeniv na tli insulinorezystentnosti. Ukrai'ns'kyj zhurnal ekstremal'noi' medycyny im. G.O. Mozhajeva. 3, 74–80.]

Copyright for articles published in the journal is regulated by the License Agreement for the use of a scientific article in the journal, which is concluded between the author of the article (Licensor) and Kharkov National Medical University (Licensee, publisher of the journal "Inter Collegas"). The licensor grants to the Licensee a non-exclusive non-exclusive license for the use of the article (a license that does not exclude the use of the article by the Licensor and the issuance of licenses to others for use of this article) on the terms and for the period specified in the contract. The licensor (the author of the article) grants the Licensee the right to reproduce the article (publication in the journal "Inter Collegas", publication, duplication, duplication or other reproduction of the article without limiting the circulation of copies, each copy of the article must contain the name of the Licensor; Of general information, including the publication of the article in full or in part on the Internet on the journal page, the right to use the metadata of the article (titles, full names of authors, annotations, bibliography eskih materials) through the dissemination and communication to the public, processing and systematization, as well as inclusion in various databases and in-formational system).

The licensor grants the licensee the right to transfer, store and process his personal data (full name, scientific degree, academic title, place of work and position, contact information of the authors) with the purpose of including them in the database in accordance with the Law of Ukraine No. 2297 - VI "on protection of personal data" from 01.06.2010.

Personal data and metadata of the article are provided for their storage and processing in various databases and information systems, including them in analytical and statistical reporting, creating sound relationships between the objects of works of science, literature and art with personal data, etc. on unlimited territory. The licensee has the right to transfer the specified data for processing and storage to third parties provided that such a fact is notified with the provision of information about the third party (name and address) to the Licensor.