How to Cite
Abstract
IMMUNOPATHOLOGICAL FEATURES OF PSORIASIS
Kharkiv National Medical University, Ukraine
Dobrzhanska Yu.
Abstract. Psoriasis, a common multifactor skin disease, has received attention as a target for new pathogenesis-oriented biologic therapies. Psoriasis is important to the clinician because it is common and has treatment implications beyond the care of skin lesions. It is important to the physician-scientist because it serves as a model for studies of mechanisms of chronic inflammation.
In recent years, substantial advances have been made in elucidating the mechanisms of psoriasis. However, major issues remain unresolved, including the primary nature of the disease as an epithelial or immunologic disorder, the autoimmune cause of the inflammatory process, the relevance of cutaneous versus systemic factors, and the role of genetic versus environmental influences on disease initiation, progression
This review summarizes recent progress in understanding of the immunologic basis of psoriasis and shows how improved insight into disease mechanisms has already resulted in tangible benefits for patients, including the introduction of new targeted therapies.
Key words: psoriasis, cytokine, interleukin, treatments for psoriasis
ІММУНОПАТОЛОГІЧНІ ОСОБЛИВОСТІ ПСОРІАЗУ
Добржанська Є.
Харьковский национальный медицинский университет, Украина
Резюме. Псориаз распространенное заболевание кожи мультифакторной природы, находится под пристальным вниманием дерматологов и ученых исследователей всего мира в качестве мишени для изучения патогенеза и поиска новых методов лечения. Изучение псориаза очень важно как для дерматологов, так и для исследователей в качестве модели для изучения механизмов хронического воспаления.
В последние годы значительные успехи были достигнуты в выяснении механизмов псориаза. Тем не менее, основные проблемы остаются нерешенными, в том числе этиология заболевания, патологические процессы в коже, иммунной системе, аутоиммунные причины воспалительного процесса, зависимость кожных проявлений от поражения других органов и систем, а также роль генетических факторов и воздействие окружающей среды на возникновение псориаза и его прогрессирование.
Представлены достижения в изучении иммунологического звена патогенеза псориаза и показано, как улучшение понимания механизмов болезни уже привело к повышению эффективности проводимой терапии.
Ключевые слова: псориаз, цитокины, интерлейкины, лечение псориаза.
ИММУНОПАТОЛОГИЧЕСКИЕ ОСОБЕННОСТИ ПСОРИАЗА
Добржанская Е.
Харьковский национальный медицинский университет, Украина
Резюме. Псоріаз поширене захворювання шкіри мультифакторної природи, перебуває під пильною увагою дерматологів і вчених дослідників усього світу в якості мішені для вивчення патогенезу та пошуку нових методів лікування. Вивчення псоріазу дуже важливо як для дерматологів, так і для дослідників в якості моделі для вивчення механізмів хронічного запалення.
В останні роки значні успіхи були досягнуті в з'ясуванні механізмів псоріазу. Тим не менше, основні проблеми залишаються невирішеними, зокрема етіологія захворювання, патологічні процеси в шкірі, імунній системі, автоімунні причини запального процесу, залежність шкірних проявів від ураження інших органів і систем, а також роль генетичних факторів і вплив навколишнього середовища на виникнення псоріазу і його прогресування.
Представлені досягнення у вивченні імунологічного ланки патогенезу псоріазу та показано, як поліпшення розуміння механізмів хвороби вже призвело до підвищення ефективності терапії.
Ключові слова: псоріаз, цитокіни, інтерлейкіни, лікування псоріазу.
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