tuberculosis, carbohydrate metabolism, insulin resistance


This review article contains current scientific literature data about the impact of infectious diseases and tuberculosis particulary on the formation of systemic insulin resistance in patients. A number of immune reactions have been reported in the host body in response to tuberculosis infection, which may lead to the development of hyperglycemia in TB patients. Some authors believe that such disorders are transient and disappear after a course of specific treatment, others - are inclined to believe that tuberculosis can cause diabetes in people who have not previously suffered from it, and long-term impairment of carbohydrate metabolism that occurs under the time of active tuberculosis process forms a vicious circle in which insufficiently controlled blood glucose levels can lead to aggravated TB and provoke complications in the form of cardiovascular disorders. Also, we found data on the transformation of latent disorders of carbohydrate metabolism in manifest diabetes mellitus during 1-4 years of follow-up of patients with tuberculosis.


Feshchenko YuI, Melnyk VM, Turchenko LV. (2016). Pohliad na problemu borotby z tuberkulozom v Ukraini [A look at the problem of tuberculosis control in Ukraine.]. Ukr. pulmonol. zhurnal. 2016. no 3, pp.5–10.

Houben, R.M., Dodd, P.J. (2016). The global burden of latent tuberculosis infection: a re-estimation using mathematical modelling. PLoS. Med. 2016. 13, e1002152

Chee, C.B.E., Reves, R., Zhang, Y., Belknap, R. (2018). Latent tuberculosis infection: Opportunities and challenges. Respirology. 2018 Oct; 23(10): 893-900. doi: 10.1111/resp.13346. Epub 2018 Jun 14. PMID: 29901251.

Dodd, C.E., Schlesinger, L.S. (2017). New concepts in understanding latent tuberculosis. Curr Opin Infect Dis. 2017 Jun; 30(3): 316-321. doi: 10.1097/QCO.0000000000000367. PMID: 28177961

Silva, D. R., Muñoz-Torrico, M., Duarte, R., Galvão, T., Bonini, E. H., Arbex, F. F., Arbex, M. A., Augusto, V. M., Rabahi, M. F., & Mello, F. (2018). Risk factors for tuberculosis: diabetes, smoking, alcohol use, and the use of other drugs. Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia, 44(2), 145–152.

Bell, L.C.K., Noursadeghi, M. (2018). Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection. Nat Rev Microbiol. 2018 Feb;16(2):80-90. doi: 10.1038/nrmicro.2017.128. Epub 2017 Nov 7. PMID: 29109555.

Workneh, M.H., Bjune, G.A., Yimer, S.A. (2017) Prevalence and associated factors of tuberculosis and diabetes mellitus comorbidity: A systematic review. PLoS One. 2017;12(4):e0175925. Published 2017 Apr 21. doi:10.1371/journal.pone.0175925

Cui, Z., Lin, M., Nie, S., & Lan, R. (2017). Risk factors associated with Tuberculosis (TB) among people living with HIV/AIDS: A pair-matched case-control study in Guangxi, China. PloS one, 12(3), e0173976.

Winter, J. R., Adamu, A. L., Gupta, R. K., Stagg, H. R., Delpech, V., & Abubakar, I. (2018). Tuberculosis infection and disease in people living with HIV in countries with low tuberculosis incidence. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 22(7), 713–722.

DIABETES ATLAS Eighth edition / International Diabetes Federation, 2017. [cited 2018 Oct 10]. 150 p. Aavilable from:

Global report on diabetes / WHO. Geneva: WHO, 2016. – 88p.

Workneh, M.H., Bjune, G.A., Yimer, S.A. (2017). Prevalence and associated factors of tuberculosis and diabetes mellitus comorbidity: A systematic review. PLoS One. 2017; 12:e0175925 eCollection 2017. [PMC free article] [PubMed] [Google Scholar]

Wang, Q., Ma, A., Han, X., Zhao, S., Cai, J., Kok, F. J., & Schouten, E. G. (2017). Hyperglycemia is associated with increased risk of patient delay in pulmonary tuberculosis in rural areas. Journal of diabetes, 9(7), 648–655.

Cadena, J., Rathinavelu, S., Lopez-Alvarenga, J. C., & Restrepo, B. I. (2019). The re-emerging association between tuberculosis and diabetes: Lessons from past centuries. Tuberculosis (Edinburgh, Scotland), 116S, S89–S97.

Cheng, J., Zhang, H., Zhao, Y. L., Wang, L. X., & Chen, M. T. (2017). Mutual Impact of Diabetes Mellitus and Tuberculosis in China. Biomedical and environmental sciences : BES, 30(5), 384–389.

Yorke, E., Atiase, Y., Akpalu, J., Sarfo-Kantanka, O., Boima, V., & Dey, I. D. (2017). The Bidirectional Relationship between Tuberculosis and Diabetes. Tuberculosis research and treatment, 2017, 1702578.

Lerner, T.R., Borel, S., Gutierrez, M.G. (2015). The innate immune response in human tuberculosis. Cellular microbiology. 2015; 17(9): 1277–85. doi:10.1111/cmi.12480.

Stutz, M. D., Clark, M. P., Doerflinger, M., & Pellegrini, M. (2018). Mycobacterium tuberculosis: Rewiring host cell signaling to promote infection. Journal of leukocyte biology, 103(2), 259–268.

McMurray, F., Patten, D. A., Harper, M. E. (2016). Reactive Oxygen Species and Oxidative Stress in Obesity-Recent Findings and Empirical Approaches. Obesity (Silver Spring). 2016 Nov;24(11):2301-2310. doi: 10.1002/oby.21654. PMID: 27804267.

Boillat-Blanco, N., Ramaiya, K. L., Mganga, M., Minja, L. T., Bovet, P., Schindler, C., Von Eckardstein, A., Gagneux, S., Daubenberger, C., Reither, K., & Probst-Hensch, N. (2016). Transient Hyperglycemia in Patients With Tuberculosis in Tanzania: Implications for Diabetes Screening Algorithms. The Journal of infectious diseases, 213(7), 1163–1172.

Menon, S., Francis, J., Zdraveska, N., Dusabimana, A., & Bhattacharyya, S. (2019). The epidemiology of intransient TB-induced hyperglycaemia in previously undiagnosed diabetes mellitus 2 individuals: a protocol for a systematic review and meta-analysis. Systematic reviews, 8(1), 234.

Hensel, R. L., Kempker, R. R., Tapia, J., Oladele, A., Blumberg, H. M., & Magee, M. J. (2016). Increased risk of latent tuberculous infection among persons with pre-diabetes and diabetes mellitus. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 20(1), 71–78.

Sharma, B., Khanal, V. K., Jha, N., Pyakurel, P., & Gurung, G. N. (2019). Study of the magnitude of diabetes and its associated risk factors among the tuberculosis patients of Morang, Eastern Nepal. BMC public health, 19(1), 1545.

American Diabetes Association: Standards of Medical Care in Diabetes — 2017. Diabetes Care. 2017;40(1):1-135. doi: 10.2337/dc17-S001.

Kaminskyi OV. (2017). Ofitsiini kryterii diahnostyky tsukrovoho diabetu, normohlikemiia i samokontrol hlikemii [Official criteria for the diagnosis of diabetes, normoglycemia and glycemic self-monitoring.]. Mizhnarodnyi endokrynolohichnyi zhurnal. 2017. Tom 13,no 3, pp.184-190

Hostalek, U. (2019). Global epidemiology of prediabetes - present and future perspectives. Clin Diabetes Endocrinol. 2019; 5:5. Published 2019 May 9. doi:10.1186/s40842-019-0080-0

Echouffo-Tcheugui, J. B., Narayan, K. M., Weisman, D. (2016). Association between prediabetes and risk of chronic kidney disease: a systematic review and meta-analysis. Diabet Med. 2016; 33:1615–24.

Stino, A. M., Smith, A. G. (2017). Peripheral neuropathy in prediabetes and the metabolic syndrome. J Diabetes Investig. 2017 Sep;8(5):646-655. doi: 10.1111/jdi.12650. Epub 2017 May 3. PMID: 28267267; PMCID: PMC5583955.

ICD-10-CM codes [].

Khan, R., Chua, Z., Tan, J. C., Yang, Y., Liao, Z., & Zhao, Y. (2019). From Pre-Diabetes to Diabetes: Diagnosis, Treatments and Translational Research. Medicina (Kaunas, Lithuania), 55(9), 546.

Carris, N. W., Magness, R. R., Labovitz, A. J. (2019). Prevention of Diabetes Mellitus in Patients With Prediabetes. Am J Cardiol. 2019 Feb 1;123(3):507-512. doi: 10.1016/j.amjcard.2018.10.032. Epub 2018 Nov 6. PMID: 30528418; PMCID: PMC6350898.

Luc, K., Schramm-Luc, A., Guzik, T. J., Mikolajczyk, T.P. (2019). Oxidative stress and inflammatory markers in prediabetes and diabetes. J Physiol Pharmacol. 2019 Dec;70(6). doi: 10.26402/jpp.2019.6.01. Epub 2020 Feb 19. PMID: 32084643.

Wang, Q., Ma, A., Han, X., Zhao, S., Cai, J., Kok, F. J., & Schouten, E. G. (2017). Hyperglycemia is associated with increased risk of patient delay in pulmonary tuberculosis in rural areas. Journal of diabetes, 9(7), 648–655.

Hasan, Z., Irfan, M., Masood, Q., Ahmed, O., Moosajee, U.S., Rao, S., Salahuddin, N. (2019). Raised levels of IFN-gamma and IL-13 are associated with pre-diabetes amongst newly diagnosed patients with Tuberculosis. J Pak Med Assoc. 2019 Apr;69(4):468-473. PMID: 31000846.

Owiti, P., Keter, A., Harries, A. D., Pastakia, S., Wambugu, C., Kirui, N., Kasera, G., Momanyi, R., Masini, E., Some, F., & Gardner, A. (2017). Diabetes and pre-diabetes in tuberculosis patients in western Kenya using point-of-care glycated haemoglobin. Public health action, 7(2), 147–154.

Hoa, N. B., Phuc, P. D., Hien, N. T., Hoa, V. Q., Thuong, P. H., Anh, P. T., & Nhung, N. V. (2018). Prevalence and associated factors of diabetes mellitus among tuberculosis patients in Hanoi, Vietnam. BMC infectious diseases, 18(1), 603.

Shivakumar, S., Chandrasekaran, P., Kumar, A., Paradkar, M., Dhanasekaran, K., Suryavarshini, N., Thomas, B., Kohli, R., Thiruvengadam, K., Kulkarni, V., Hannah, L. E., Sivaramakrishnan, G. N., Pradhan, N., Dolla, C., Gupte, A., Ramachandran, G., DeLuca, A., Meshram, S., Bhardawaj, R., Bollinger, R. C., … Gupta, A. (2018). Diabetes and pre-diabetes among household contacts of tuberculosis patients in India: is it time to screen them all?. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 22(6), 686–694.

Ratnawati, D. W., Ahmad, M. N., Fariz, N., Erlina. B. (2018). The relationship between hemoglobin A1C levels and sputum conversion time in Indonesian patients with new cases of pulmonary tuberculosis. The Journal of Natural Science, Biology and Medicine. 2018.; vol.9 (2), 217 - 221. 10.4103/jnsbm.JNSBM_24_18.

Han, H.S., Kang, G., Kim, J.S., Choi, B.H., Koo, S.H. (2016). Regulation of glucose metabolism from a liver-centric perspective. Exp Mol Med. 2016 Mar 11; 48:e218. doi: 10.1038/emm.2015.122. Review. PubMed PMID: 26964834; PubMed Central PMCID: PMC4892876.

Melkonian, E.A., Asuka, E., Schury, M.P. (2020). Physiology, Gluconeogenesis. 2020 May 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. PMID: 31082163.

Adeva-Andany, M.M., Pérez-Felpete, N., Fernández-Fernández, C., Donapetry-García, C., Pazos-García, C. (2016). Liver glucose metabolism in humans. Biosci Rep. 2016 Nov 29;36(6):e00416. doi: 10.1042/BSR20160385. PMID: 27707936; PMCID: PMC5293555.

Legouis, D., Faivre, A., Cippà, P. E,, de Seigneux, S. (2020). Renal gluconeogenesis: an underestimated role of the kidney in systemic glucose metabolism. Nephrol Dial Transplant. 2020 Nov 28:gfaa302. doi: 10.1093/ndt/gfaa302. Epub ahead of print. PMID: 33247734.

Melkonian, E. A., Schury, M. P. (2020). Biochemistry, Anaerobic Glycolysis. 2020 Oct 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. PMID: 31536301.

Petersen, M.C., Shulman, G. I. (2018). Mechanisms of Insulin Action and Insulin Resistance. Physiol Rev. 2018;98(4):2133-2223. doi:10.1152/physrev.00063.2017

Kursov S V Nikonov V V 2019 Stressovaia giperglikemiia obsuzhdenie puti ee ustraneniia s pomoshchiu primeneniia mnogoatomnykh spirtov [Stress hyperglycemia: discussion of ways to eliminate it with the use of polyhydric alcohols]. Meditsina neotlozhnykh sostoianii 2019, no 4(99), pp.48-55

Di Pino, A., DeFronzo, R. A. (2019). Insulin Resistance and Atherosclerosis: Implications for Insulin-Sensitizing Agents. Endocr Rev. 2019;40(6):1447-1467. doi:10.1210/er.2018-00141

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