Keywords
How to Cite
Abstract
Over the last many years, cardiovascular disease has reached epidemic proportions among chronic noncommunicable diseases worldwide. According to the latest tendencies, cardiovascular diseases play the leading role in the formation of current negative health and demographic trends in Ukraine and all over the
world: they significantly affect the main health indicators: morbidity, mortality, disability, life expectancy and quality of life. If we take the last 20 years, we can see that the prevalence of CVDs among the Ukrainian population has tripled, and the mortality rate from them has risen by 40%. Review was analysed serum level
insulin-like growth factor-I (IGF-I) in patients with acute myocardial infarction and his role in left ventricular remodelling was established. The scientific data regarding the neurohumoral component of acute myocardial infarction pathogenesis have been expanded by increasing levels of the angiogenesis marker IGF-I, which can be explained by his properties as markers of the acute phase of inflammation. An analysis of the relationship between troponin I and IGF-I, a marker of myocardial damage, showed a direct relationship, indicating an increase in troponin I concentration with rising serum IGF-I levels. This indicates that the activity of the angiogenesis marker IGF-I may be associated with the severity and depth of myocardial damage.
References
Kovalenko V.M, Kornatsʹkyy V.M, Moroz D.M, y dr. (2016). Problemy zdorovʺya i medychnoyi dopomohy ta modelʹ pokrashchannya v suchasnykh umovakh [Problems of health and medical care - a model for improvement in modern conditions].– Kyyiv: Instytut kardiolohiyi imeni akademika M. D. Strazheska NAMN Ukrayiny, p. 261.
Kovalenko VM, Dorohoy AP. (2016). Sertsevo-sudynni khvoroby: medychno-sotsialʹne znachennya ta stratehiya rozvytku kardiolohiyi v Ukrayini [Cardiovascular diseases: medical and social significance and strategy for the development of cardiology in Ukraine]. Materialy XVII Natsionalʹnoho konhresu kardiolohiv Ukrayiny; Kyyiv, Ukrayina. pp. 5-14.
Vázquez-Oliva G., Zamora A., Ramos R., Marti R., Subirana I., Grau M et al. (2018). Acute Myocardial Infarction Population Incidence and Mortality Rates, and 28-day Case-fatality in Older Adults. The REGICOR Study. Rev Esp Cardiol (Engl Ed), 71, 718-725. English, Spanish. doi: 10.1016/j.rec.2017.10.019. Epub 2017 Nov 22. PMID: 29174866.
Bradley S.M., Borgerding J.A., Wood G.B., Maynard C., Fihn S.D. (2019). Incidence, Risk Factors, and Outcomes Associated With In-Hospital Acute Myocardial Infarction. JAMA Netw Open, 2(1), e187348. doi: 10.1001/jamanetworkopen.2018.7348. PMID: 30657538; PMCID: PMC6484558.
Quadros A.S., Cambruzzi E., Sebben J., David R.B., Abelin A., Welter D. et al. (2012). Red versus white thrombi in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: clinical and angiographic outcomes. Am Heart J, 164(4), 553-60. doi: 10.1016/j.ahj.2012.07.022. PMID: 23067914.
Sakalaki M., Hansson P.O., Rosengren A. et al. (2021). Multi-modality biomarkers in the early prediction of ischaemic heart disease in middle-aged men during a 21-year follow-up. BMC Cardiovasc Disord., 21, 65. https://doi.org/10.1186/s12872-021-01886-x
Ghantous C.M., Kamareddine L., Farhat R., Zouein F.A., Mondello S., Kobeissy F., Zeidan A. (2020). Advances in Cardiovascular Biomarker Discovery. Biomedicines, 8(12), 552. https://doi.org/10.3390/biomedicines8120552
Kopytsya M., Hilova Y., Rodionova Y., Polivenok I., Shelest B. (2021). Soluble ST2 in Predicting Adverse Outcome after Revascularization with Percutaneous Coronary Intervention in Patients with ST-Elevation Myocardial Infarction. Duzce Medical Journal, 23(2), 174-180. DOI: 10.18678/dtfd.889947
Li X., Liu Q., Zhou T., Zhao S., Zhou S. (2008). PAPP-A: a possible pathogenic link to the instability of atherosclerotic plaque. Med Hypotheses, 70(3), 597-599. doi: 10.1016/j.mehy.2007.05.043. PMID: 17714879.
Lund J., Qin Q.P., Ilva T., Pettersson K., Voipio-Pulkki L.M., Porela P., Pulkki K. (2003). Circulating pregnancy-associated plasma protein a predicts outcome in patients with acute coronary syndrome but no troponin I elevation. Circulation, 108(16), 1924-1926. doi: 10.1161/01.CIR.0000096054.18485.07. PMID: 14530192.
Ohlsson C., Mohan S., Sjögren K., Tivesten A., Isgaard J., Isaksson O., et al. (2009). The role of liver-derived insulin-like growth factor-I. Endocr Rev., 30(5), 494-535. doi: 10.1210/er.2009-0010. PMID: 19589948; PMCID: PMC2759708.
Bach L.A., Hale L.J. (2015). Insulin-like growth factors and kidney disease. Am J Kidney Dis., 65(2), 327-336. doi: 10.1053/j.ajkd.2014.05.024. PMID: 25151409.
Shevchenko A.O., Slesareva Iu.S., Shevchenko O.P. (2011). Laboratory diagnosis of atherosclerotic plaque damage in patients with coronary heart disease: PAPP-A (a review of literature). Klin Lab Diagn., 5, 3-10. PMID: 21786607.
Consuegra-Sanchez L., Petrovic I., Cosin-Sales J., Holt D.W., Christiansen M., Kaski J.C. (2008). Prognostic value of circulating pregnancy-associated plasma protein-A (PAPP-A) and proform of eosinophil major basic protein (pro-MBP) levels in patients with chronic stable angina pectoris. Clin Chim Acta., 391(1-2), 18-23. doi: 10.1016/j.cca.2008.01.012. PMID: 18267116.
Hausenloy D.J., Yellon D.M. (2004). New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res., 61(3), 448-460. doi: 10.1016/j.cardiores.2003.09.024. PMID: 14962476.
Buerke M., Murohara T., Skurk C., Nuss C., Tomaselli K., Lefer A.M. (1995). Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion. Proc Natl Acad Sci U S A., 92 (17), 8031-8035. doi: 10.1073/pnas.92.17.8031. PMID: 7644533; PMCID: PMC41280.
Davani E.Y., Brumme Z., Singhera G.K., Côté H.C., Harrigan P.R., Dorscheid D.R. (2003). Insulin-like growth factor-1 protects ischemic murine myocardium from ischemia/reperfusion associated injury. Crit Care., 7(6), 176-183. doi: 10.1186/cc2375. PMID: 14624693; PMCID: PMC374373.
O'Sullivan J.F., Leblond A.L., Kelly G., Kumar A.H., Metharom P., Büneker C.K. et al. (2011). Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction. Circ Cardiovasc Interv., 4, 327-335. doi: 10.1161/CIRCINTERVENTIONS.110.960765. PMID: 21712526.
Padin-Iruegas M.E., Misao Y., Davis M.E., Segers V.F., Esposito G., Tokunou T. et al. (2009). Cardiac progenitor cells and biotinylated insulin-like growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction. Circulation. 120(10), 876-887. doi: 10.1161/CIRCULATIONAHA.109.852285. PMID: 19704095; PMCID: PMC2913250.
Kin H., Zhao Z.Q., Sun H.Y., Wang N.P., Corvera J.S., Halkos M.E. et al. (2004). Postconditioning attenuates myocardial ischemia-reperfusion injury by inhibiting events in the early minutes of reperfusion. Cardiovasc Res., 62(1), 74-85. doi: 10.1016/j.cardiores.2004.01.006. PMID: 15023554.
Li B., Setoguchi M., Wang X., Andreoli A.M., Leri A., Malhotra A. et al. (1999). Insulin-like growth factor-1 attenuates the detrimental impact of nonocclusive coronary artery constriction on the heart. Circ Res., 84(9), 1007-1019. doi: 10.1161/01.res.84.9.1007. PMID: 10325238.
Redaelli G., Malhotra A., Li B., Li P., Sonnenblick E.H., Hofmann P.A., Anversa P. (1998). Effects of constitutive overexpression of insulin-like growth factor-1 on the mechanical characteristics and molecular properties of ventricular myocytes. Circ Res., 82(5), 594-603. doi: 10.1161/01.res.82.5.594. PMID: 9529164.
Cittadini A., Ishiguro Y., Strömer H., Spindler M., Moses A.C., Clark R. et al. (1998). Insulin-like growth factor-1 but not growth hormone augments mammalian myocardial contractility by sensitizing the myofilament to Ca2+ through a wortmannin-sensitive pathway: studies in rat and ferret isolated muscles. Circ Res., 83(1), 50-59. doi: 10.1161/01.res.83.1.50. PMID: 9670918.
Higashi Y., Gautam S., Delafontaine P., Sukhanov S. (2019). IGF-1 and cardiovascular disease. Growth Horm IGF Res., 45, 6-16. doi: 10.1016/j.ghir.2019.01.002. PMID: 30735831; PMCID: PMC6504961.
Ghosh R., Karmohapatra S.K., Bhattacharyya M., Bhattacharya R., Bhattacharya G., Sinha A.K. (2011). The appearance of dermcidin isoform 2, a novel platelet aggregating agent in the circulation in acute myocardial infarction that inhibits insulin synthesis and the restoration by acetyl salicylic acid of its effects. J Thromb Thrombolysis. 31(1), 13-21. doi: 10.1007/s11239-010-0515-z. PMID: 20809104.
Ray U., Khan G.A., Chakraborty K., Basuroy S., Patra S.C., Girish G. et al. (2012). Isolation and study of insulin activated nitric oxide synthase inhibitory protein in acute myocardial infarction subjects. J Thromb Thrombolysis, 33(3), 218-229. doi: 10.1007/s11239-011-0672-8. PMID: 22238031.
Friberg L., Werner S., Eggertsen G., Ahnve S. (2000). Growth hormone and insulin-like growth factor-1 in acute myocardial infarction. Eur Heart J., 21(18), 1547-1554. doi: 10.1053/euhj.2000.2125. PMID: 10973769.
Spallarossa P., Brunelli C., Minuto F., Caruso D., Battistini M., Caponnetto S., Cordera R. (1996). Insulin-like growth factor-I and angiographically documented coronary artery disease. Am J Cardiol., 77(2), 200-202. doi: 10.1016/s0002-9149(96)90600-1. PMID: 8546095.
Fan J., Wojnar M.M., Theodorakis M., Lang C.H. (1996). Regulation of insulin-like growth factor (IGF)-I mRNA and peptide and IGF-binding proteins by interleukin-1. Am J Physiol., 270(3), 621-629. doi: 10.1152/ajpregu.1996.270.3.R621. PMID: 8780229.
Lang C.H., Fan J., Cooney R., Vary T.C. (1996). IL-1 receptor antagonist attenuates sepsis-induced alterations in the IGF system and protein synthesis. Am J Physiol., 270(3), 430-437. doi: 10.1152/ajpendo.1996.270.3.E430. PMID: 8638689.
Zhang X., Xing H., Qi F., Liu H., Gao L., Wang X. (2020). Local delivery of insulin/IGF-1 for bone regeneration: carriers, strategies, and effects. Nanotheranostics, 4, 242-255. doi: 10.7150/ntno.46408. PMID: 32923314; PMCID: PMC7484631.
Sarzi-Puttini P., Atzeni F., Schölmerich J., Cutolo M., Straub R.H. (2006). Anti-TNF antibody treatment improves glucocorticoid induced insulin-like growth factor 1 (IGF1) resistance without influencing myoglobin and IGF1 binding proteins 1 and 3. Ann Rheum Dis., 65(3), 301-305. doi: 10.1136/ard.2005.040816. Epub 2005 Aug 3. PMID: 16079165; PMCID: PMC1798065.
Salmon A.B., Lerner C., Ikeno Y., Motch Perrine S.M., McCarter R., Sell C. (2015). Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I. Am J Physiol Endocrinol Metab., 308(7), 545-553. doi: 10.1152/ajpendo.00558.2014. PMID: 25648834; PMCID: PMC4385875.
Kuemmerle J.F. (2012). Insulin-like growth factors in the gastrointestinal tract and liver. Endocrinol Metab Clin North Am., 41(2), 409-423, vii. doi: 10.1016/j.ecl.2012.04.018. PMID: 22682638; PMCID: PMC3372868.
Aoi N., Nakayama T., Soma M., Kosuge K., Haketa A., Sato M. et al. (2010). Association of the insulin-like growth factor1 gene with myocardial infarction in Japanese subjects. Hereditas, 147(5), 215-24. doi: 10.1111/j.1601-5223.2010.02174.x. PMID: 21039458.
Janssen J.A., Stolk R.P., Pols H.A., Grobbee D.E., Lamberts S.W. (1998). Serum total IGF-I, free IGF-I, and IGFB-1 levels in an elderly population: relation to cardiovascular risk factors and disease. Arterioscler Thromb Vasc Biol., 18(2), 277-282. doi: 10.1161/01.atv.18.2.277. PMID: 9484994.
Juul A., Scheike T., Davidsen M., Gyllenborg J., Jørgensen T. (2002). Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study. Circulation, 106(8), 939-944. doi: 10.1161/01.cir.0000027563.44593.cc. PMID: 12186797.
Ittermann T., Noord Cv., Friedrich N., Dörr M., Felix S.B., Nauck M. et al. (2012). The association between insulin-like growth factor-I and cardiac repolarization. Growth Horm IGF Res., 22(1), 1-5. doi: 10.1016/j.ghir.2011.11.001. PMID: 22154520.
Schneider H.J., Klotsche J., Saller B., Böhler S., Sievers C., Pittrow D. et al. (2008). Associations of age-dependent IGF-I SDS with cardiovascular diseases and risk conditions: cross-sectional study in 6773 primary care patients. Eur J Endocrinol., 158(2), 153-61. doi: 10.1530/EJE-07-0600. PMID: 18230821.
Burchardt P., Tabaczewski P., Goździcka-Józefiak A., Siminiak T., Szczepaniak A., Banaszak A., Wysocki H. (2012). Association between insulin like growth factor-1 and lipoprotein metabolism in stable angina patients on statin therapy: a pilot study. Kardiol Pol., 70(10), 1017-1022. PMID: 23080092.
Martovytskyi D., Kravchun P., Shelest O. (2018). Effect of obesity presence on insulin-like growth factor-1 and endostatin in patients with myocardial infarction. Georgian Med News, 284, 55-58. PMID: 30618390.
Colao A., Spiezia S., Di Somma C., Pivonello R., Marzullo P., Rota F. et al. (2005). Circulating insulin-like growth factor-I levels are correlated with the atherosclerotic profile in healthy subjects independently of age. J Endocrinol Invest., 28(5), 440-8. doi: 10.1007/BF03347225. PMID: 16075928.
Andrade D., Oliveira G., Menezes L., Nascimento A.L., Carvalho S., Stumbo A.C. et al. (2020). Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice. Nutr Metab Cardiovasc Dis., 30(1), 151-161. doi: 10.1016/j.numecd.2019.09.001. PMID: 31753790.
Conti E., Andreotti F., Sciahbasi A., Riccardi P., Marra G., Menini E. et al. (2001). Markedly reduced insulin-like growth factor-1 in the acute phase of myocardial infarction. J Am Coll Cardiol., 38(1), 26-32. doi: 10.1016/s0735-1097(01)01367-5. PMID: 11451284.
Davis M.E., Hsieh P.C., Takahashi T., Song Q., Zhang S., Kamm R.D. et al. (2006). Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc Natl Acad Sci U S A, 103(21), 8155-8160. doi: 10.1073/pnas.0602877103. PMID: 16698918; PMCID: PMC1472445.
"Inter Collegas" is an open access journal: all articles are published in open access without an embargo period, under the terms of the CC BY-NC-SA (Creative Commons Attribution ‒ Noncommercial ‒ Share Alike) license; the content is available to all readers without registration from the moment of its publication. Electronic copies of the archive of journals are placed in the repositories of the KhNMU and V.I. Vernadsky National Library of Ukraine.
Copyright Agreement
1. This Agreement on the transfer of rights to use the work from the Co-authors to the publisher (hereinafter the Agreement) is concluded between all the Co-authors of the work, represented by the Corresponding Author, and Kharkiv National Medical University (hereinafter the University), represented by an authorized representative of the Editorial Board of scientific journals (hereinafter the Editorial Board).
2. This Agreement is an accession agreement within the meaning of clause 1 of Article 634 of the Civil Code of Ukraine: that is, a contract, "the terms of which are established by one of the parties in forms or other standard forms, which can be concluded only by joining the other party to the proposed contract as a whole. The other party cannot offer its terms of the contract." The party that established the terms of this contract is the University.
3. If there is more than one author, the authors choose the Corresponding Author, who communicates with the Editorial Board on his own behalf and on behalf of all Co-authors regarding the publication of a written work of a scientific nature (article or review, hereinafter referred to as the Work).
4. The contract begins from the moment of submission of the manuscript of the Work by the Corresponding Author to the Editorial Board, which confirms the following:
4.1. all Co-authors of the Work are familiar with and agree with its content, at all stages of reviewing and editing the manuscript and the existence of the published Work;
4.2. all Co-authors of the Work are familiar with and agree to the terms of this Agreement.
5. The published Work is in electronic form in public access on the websites of the University and any websites and electronic databases in which the Work is posted by the University and is available to readers under the terms of the "Creative Commons" license (Attribution NonCommercial Sharealike 4.0 International)" or more free licenses "Creative Commons 4.0".
6. The Corresponding Author transfers, and the University receives, the non-exclusive property right to use the Work by placing the latter on the University's websites for the entire term of copyright. The University participates in the creation of the final version of the Work by reviewing and editing the manuscript of the article or review provided to the Editorial Board by the Corresponding Author, translating the Work into any languages. For the participation of the University in the finalization of the Work, the Co-authors agree to pay the invoice issued to them by the University, if such payment is provided by the University. The size and procedure of such payment are not the subject of this contract.
7. The University has the right to reproduce the Work or its parts in electronic and printed forms, to make copies, permanent archival storage of the Work, distribution of the Work on the Internet, repositories, scientometric databases, commercial networks, including for monetary compensation from third parties.
8. The co-authors guarantee that the manuscript of the Work does not use works whose copyright belongs to third parties.
9. The authors of the Work guarantee that at the time of submission of the manuscript of the Work to the Editorial Board, the property rights to the Work belong only to them, neither in whole nor in part have they been transferred to anyone (not alienated), they are not the subject of a lien, litigation or claims by third parties.
10. The Work may not be posted on the University's website if it violates a person's right to the privacy of his personal and family life, harms public order and health.
11. The work may be withdrawn by the Editorial Board from the University websites, libraries and electronic databases where it was placed by the Editorial Board, in cases of detection of violations of the ethics of the authors and researchers, without any compensation for the losses of the Co-authors. At the time of submission of the manuscript to the Editorial Board and all stages of its editing and review, the manuscript must not have already been published or submitted to other editorial offices.
12. The right transferred under this Agreement extends to the territory of Ukraine and foreign countries.
13. The rights of Co-authors include the requirement to indicate their names on all copies of the Work or during any public use or public mention of the Work; the requirement to preserve the integrity of the Work; legal opposition to any distortion or other encroachment on the Work, which may harm the honor and reputation of the Co-authors.
14. Co-authors have the right to control their personal non-property rights by familiarizing themselves with the text (content) and form of the Work before its publication on the University's website, when transferring it to a printing company for reproduction or when using the Work in other ways.
15. The Co-authors, in addition to the property rights not transferred under this Agreement and taking into account the non-exclusive nature of the rights transferred under this Agreement, retain the property rights to finalize the Work and to use certain parts of the Work in other works created by the Co-authors.
16. The Co-authors are obliged to notify the Editorial Board of all errors in the Work, discovered by them independently after the publication of the Work, and to take all measures to eliminate such errors as soon as possible.
17. The University undertakes to indicate the names of the Co-authors on all copies of the Work during any public use of the Work. The list of Co-authors may be shortened according to the rules for the formation of bibliographic descriptions determined by the University or third parties.
18. The University undertakes not to violate the integrity of the Work, to agree with the Corresponding Author on all changes made to the Work during processing and editing.
19. In case of violation of their obligations under this Agreement, its parties bear the responsibility defined by this Agreement and the current legislation of Ukraine. All disputes under the Agreement are resolved through negotiations, and if the negotiations do not resolve the dispute – in the courts of the city of Kharkiv.
20. The parties are not responsible for the violation of their obligations under this Agreement, if it occurred through no fault of theirs. The party is considered innocent if it proves that it has taken all measures dependent on it for the proper fulfillment of the obligation.
21. The Co-authors are responsible for the truthfulness of the facts, quotes, references to legislative and regulatory acts, other official documentation, the scientific validity of the Work, all types of responsibility to third parties who have claimed their rights to the Work. The co-authors reimburse the University for all costs caused by claims of third parties for infringement of copyright and other rights to the Work, as well as additional material costs related to the elimination of identified defects.