SARS-CoV-2, post COVID-19, ACE2, cytokines


The review article features the peculiarities in the epidemiological and clinical picture of a new coronavirus infection, COVID-19. The purpose of the review was to analyze the issues of the management. Pathogenetic relationships between SARS-CoV-2 virus, COVID-19 and angio- tensin-converting enzyme 2 (ACE2) are assessed. Predisposing factors, which result in devel- opment of pneumonia and endothelial dysfunction, disorders in microcirculation, vasocon- striction, work of the renin-angiotensin system with subsequent development of ischemia in certain organs, inflammation and edema of tissues, are analyzed. Lung damage causes devel- opment of interstitial pneumonia, activation of the process of formation of fibrosis and de- creased pulmonary function. Accumulation of anti-inflammatory cytokines, which break the blood-brain barrier, in the CNS can cause dysregulation of central structures, autonomic dys- function and severe asthenic syndrome, which can maintain low-grade inflammation for a long time. Opportune diagnosis and treatment of concomitant diseases in post-COVID-19 patients are of paramount significance for achieving a positive clinical outcome. The plan of rehabilita- tion treatment should be individualized according to the patient’s needs. In order to assess re- mote consequences of COVID-19 all patients require further follow-ups.


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