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Abstract
THE LEVEL OF NEUROACTIVE AMINO ACIDS IN BLOOD PLASMA OF PSORIATIC PATIENTS Bilovol A.M., Tkachenko S.G. Kharkiv national medical university, Kharkiv, Ukraine Abstract. Some amino acids neurotransmitters, such as glutamate, aspartate, glycine and γ-аminobutyric acid may be involved in the pathogenesis of psoriasis and hypertension. But their relationship with dermatosis severity and comorbidities are unclear. The aim of this study was to quantify level of activating and inhibitory amino acids in blood plasma of the patients suffering from isolated psoriasis and psoriasis combined with hypertension depending on severity of disease. The study was conducted on two groups of patients, first group consisted of 74 patients with isolated psoriasis, second group consisted of 48 patients with psoriasis combined with hypertension, control group comprised 30 practically healthy patients. Blood plasma level of glycine, glutamate, aspartate and γ-aminobutyric acid were defined by liquid chromatographic analysis. Severe course of psoriasis, especially combined with hypertension is characterized by excitatory and inhibitory mechanisms imbalance with signs of protective inhibition insufficiency; deficiency of GABAergic protective mechanisms along with increased release of excitatory amino acids determines the severity of psoriasis in this contingent of patients. Changes of the level of excitatory and inhibitory amino acids in blood plasma of psoriatic patients indicate their obvious participation in formation of cerebral circulation disturbance and autonomic regulation of peripheral vessels disorder. Кeywords: aspartate, GABA, glutamate, glycine, neuroactive aminoacids, psoriasis. РІВЕНЬ НЕЙРОАКТИВНИХ АМІНОКИСЛОТ В ПЛАЗМІ КРОВІ ХВОРИХ НА ПСОРІАЗ Біловол А.М., Ткаченко С.Г. Харківський національний медичний університет, м. Харків, Україна Резюме. Деякі нейромедіаторні амінокислоти, такі як глутамат, аспартат, гліцин, γ-аміномасляна кислота, можуть бути залучені до патогенезу псоріазу та артеріальної гіпертензії. Однак, їхня асоціація з тяжкістю дерматозу та коморбідністю не з’ясована. Дослідження було визначення рівня активуючих та інгібуючи амінокислот у плазмі крові пацієнтів, що страждають на ізольований псоріаз та псоріаз у сполучення з гіпертензією в залежності від тяжкості дерматозу. Дослідження проводилося в двух групах пацієнтів, перша з яких включала 74 хворих на псоріаз, друга – 48 пацієнтів з псоріазом у сполученні з артеріальною гіпертензією; контрольну групу складали 30 практично здорових осіб. Рівень гліцина, глутамата, аспартата та γ-аміномасляної кислоти визначали методом рідинної хроматографії. Тяжкий ступінь псоріазу, особливо у сполученні з гіпертензією, характеризувався дисбалансом збуджувальних та гальмівних механізмів з ознаками недостатності захисного інгібування. Недостатність ГАМК-ергічних захисних механізмів на фоні збільшення рівня збуджувальних амінокислот визначає тяжкість перебігу псоріазу. Дисбаланс нейроамінокислот в плазмі крові псоріатичних пацієнтів свідчить про порушення церебральної гемодинаміки та вегетативної регуляції периферійних судин у хворих на псоріаз. Ключові слова: аспартат, ГАМК, гліцин, глутамат, нейроактивні амінокислоти, псоріаз УРОВЕНЬ НЕЙРОАКТИВНЫХ АМИНОКИСЛОТ В ПЛАЗМЕ КРОВИ БОЛЬНЫХ ПСОРИАЗОМ. Беловол А.Н., Ткаченко С.Г. Харьковский национальный медицинский университет, г. Харьков, Украина Резюме. Некоторые нейромедиаторные аминокислоты, такие как глутамат, аспартат, глицин, γ-аминомасляная кислота, могут быть вовлечены в патогенез псориаза и артериальной гипертензии. Однако их ассоциация с тяжестью дерматоза и коморбидностью не ясна. Целью исследования было определение уровня активирующих и ингибирующих аминокислот в плазме крови пациентов, страдающих изолированным псориазом и псориазом в сочетании с гипертензией в зависимости от тяжести дерматоза. Исследование проводилось в двух группах пациентов, первая из которых включала 74 больных псориазом, вторая – 48 пациентов с псориазом в сочетании с артериальной гипертензией; контрольную группу составили 30 практически здоровых лиц. Уровень глицина, глутамата, аспартата и γ-аминомасляной кислоты определяли методом жидкостной хроматографии. Тяжелая степень псориаза, особенно в сочетании с гипертензией характеризовалась дисбалансом возбуждающих и тормозящих механизмов с признаками недостаточности защитного ингибирования. Дефицит ГАМК-эргических защитных механизмов на фоне повышения уровня возбуждающих аминокислот определяет тяжесть течения псориаза . Дисбаланс нейроаминокислот в плазме крови псориатических пациентов свидетельствует о нарушениях церебральной гемодинамики и вегетативной регуляции периферических сосудов у больных псориазом. Ключевые слова: аспартат, ГАМК, глицин, глутамат, нейроактивные аминокислоты, псориаз
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